Cerebral hemodynamics and metabolism in mental deficiency

Fazekas, Joseph F.; Ehrmantraut, Wilfred R.; Shea, James G.; Kleh, Jack

doi:10.1212/wnl.8.7.558

Cited by 13 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cerebral circulation and metabolism in autism have been studied only recently (Rumsey et al 1985;Sherman et al 1984). However, in mental retardation the measurements of global cerebral blood flow and oxygen metabolism were performed in the 1950s and 1960s using the Kety-Schmidt nitrous oxide method (Garfunkel et al 1954;Fazekas et al 1958;Lassen et al 1966;Kennedy 1967). In these studies, no obvious defects in cerebral haemodynamics and oxygen utilization were seen in cases of ' pure' mental retardation, whether non-specific or due to Down's syndrome; variable reductions in flow and metabolism were found when mental deficiency was accompanied by gross neurological abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults

Herold

Frackowiak²,

Couteur³

et al. 1988

Psychol. Med.

View full text Add to dashboard Cite

SynopsisRegional cerebral blood flow, oxygen consumption and glucose consumption were measured by positron emission tomography in six young autistic men. No significant differences were found between patients and normal controls for any of the physiological variables. The results do not substantiate the previous finding of glucose hypermetabolism in autism; the likely reasons for the variance in findings are discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults

Herold

Frackowiak²,

Couteur³

et al. 1988

Psychol. Med.

View full text Add to dashboard Cite

show abstract

“…The assumption that animals select responses from a set of alternatives is a convenient simplification. In some instances this assumption may be misleading, because many behavior patterns can probably be so altered by the context of their occurrence that they cannot be identified as fixed, selectable not differ significantly from their respective values in age-matched controls (6). In a study of halothane-anesthetized DS subjects (mean age, 29 years), the cerebral arteriovenous oxygen difference was greater, blood flow was reduced, and oxygen consumption was unchanged, compared to corresponding values in age-matched controls (7).…”

mentioning

confidence: 99%

Down's Syndrome in Adults: Brain Metabolism

Schwartz

Duara

Haxby

et al. 1983

Science

View full text Add to dashboard Cite

The cerebral metabolic rate for glucose, as measured with positron emission tomography and fluorine-18-labeled 2-deoxy-D-glucose, was significantly higher in four healthy young subjects with trisomy 21 syndrome (Down's syndrome) than the mean rate in healthy young controls. The rate of cerebral glucose utilization in the frontal lobe of a 51-year-old subject with Down's syndrome was significantly lower than the rate in the young subjects with this syndrome, but approximated the rate in middle-aged controls. Thus glucose utilization by the brain appears to be excessive in young adults with Down's syndrome but may decline with age in some brain regions.

show abstract

“…to determine whether the rCBF is also altered in Down's syndrome. Older studies using the Kety-Schmidt technique showed either reduction (in halothane-anesthetized patients) or n o change of CBF in patients with Down's syndrome [7,9). We therefore used the xenon 133 inhalation technique C12, 13) to measure the resting-state rCBF in patients with Down's syndrome and in patients with Alzheimer's disease.…”

mentioning

confidence: 99%

Regional cerebral blood flow in down's syndrome

Melamed

Mildworf

Sharav

et al. 1987

Annals of Neurology

View full text Add to dashboard Cite

Regional cerebral blood flow was measured in 14 patients with Down's syndrome, in 46 patients with Alzheimer's disease and senile dementia of the Alzheimer type, and in 114 age-matched controls, using the xenon 133 inhalation technique. Cerebral blood flow was reduced in 13 of 14 Down's patients by a mean of 16.8 +/- 2.5% from expected age-matched normal values. Degrees of regional cerebral blood flow reduction did not differ among the frontal, temporal, parietal, and occipital regions in both cerebral hemispheres. The regional cerebral blood flow decreases were similar in magnitude and pattern to those in Alzheimer patients. These findings constitute an additional similarity between the two disorders.

show abstract

Cerebral hemodynamics and metabolism in mental deficiency

Cited by 13 publications

References 0 publications

Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults

Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults

Down's Syndrome in Adults: Brain Metabolism

Regional cerebral blood flow in down's syndrome

Contact Info

Product

Resources

About