Cerebral hemodynamics during sensorimotor activation in humans

Sitzer, Matthias; Knorr, U.; Seitz, R. J.

doi:10.1152/jappl.1994.77.6.2804

Cited by 53 publications

(38 citation statements)

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“…The initial temporal pattern of CBFv response, involving a steep bilateral increase, is consistent with former TCD studies using a broad variety of brain activation paradigms (4,14,15,22,24,29,30,32,37). In keeping with our results, Duscheck et al (15) found the effects of BP on CBFv responses during arithmetic processing were also more pronounced during the first second of the response.…”

Section: Discussionsupporting

confidence: 92%

Active, passive, and motor imagery paradigms: component analysis to assess neurovascular coupling

Salinet

Robinson

Panerai

2013

Journal of Applied Physiology

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The association between neural activity and cerebral blood flow (CBF) has been used to assess neurovascular coupling (NVC) in health and diseases states, but little attention has been given to the contribution of simultaneous changes in peripheral covariates. We used an innovative approach to assess the contributions of arterial blood pressure (BP), PaCO2, and the stimulus itself to changes in CBF velocities (CBFv) during active (MA), passive (MP), and motor imagery (MI) paradigms. Continuous recordings of CBFv, beat-to-beat BP, heart rate, and breath-by-breath end-tidal CO2 (EtCO2) were performed in 17 right-handed subjects before, during, and after motor-cognitive paradigms performed with the right arm. A multivariate autoregressive-moving average model was used to calculate the separate contributions of BP, EtCO2, and the neural activation stimulus (represented by a metronome on-off signal) to the CBFv response during paradigms. Differences were found in the bilateral CBFv responses to MI compared with MA and MP, due to the contributions of stimulation (P < 0.05). BP was the dominant contributor to the initial peaked CBFv response in all paradigms with no significant differences between paradigms, while the contribution of the stimulus explained the plateau phase and extended duration of the CBFv responses. Separating the neural activation contribution from the influences of other covariates, it was possible to detect differences between three paradigms often used to assess disease-related NVC. Apparently similar CBFv responses to different motor-cognitive paradigms can be misleading due to the contributions from peripheral covariates and could lead to inaccurate assessment of NVC, particularly during MI.

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Section: Discussionsupporting

confidence: 92%

Active, passive, and motor imagery paradigms: component analysis to assess neurovascular coupling

Salinet

Robinson

Panerai

2013

Journal of Applied Physiology

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“…Here fTCD holds promise as a complementary technique, since the perfusional changes assessed by fTCD are similar to those detected by fMRI but without the above restrictions. 12 The physiological information obtained by either fTCD or the Wada test depends on the arterial distribution under study. While the amobarbital injection during the Wada test impairs cerebral function within the territory of the internal carotid artery, fTCD operates more selectively by pinpointing the distribution of a specific pial artery, eg, the MCA.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Determination of Language Lateralization by Functional Transcranial Doppler Sonography

Knecht

Deppe

Ebner

et al. 1998

Stroke

206

151

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Background and Purpose-Functional transcranial Doppler ultrasonography (fTCD) can assess event-related changes in cerebral blood flow velocities and, by comparison between sides, can provide a measure of hemispheric perfusional lateralization. It is easily applicable, insensitive to movement artifacts, and can be used in patients with less than perfect cooperation. In the present study we investigated the validity of fTCD in determining the hemispheric dominance for language by direct comparison of fTCD with intracarotid amobarbital anesthesia (Wada test). Methods-fTCD and the Wada test were performed in 19 patients evaluated for epilepsy surgery. By the Wada test, 13 patients were classified as left-hemisphere dominant and 6 as right-hemisphere dominant for language. fTCD was based on the continuous bilateral measurements of blood flow velocities in the middle cerebral arteries and event-related averaging during a cued word generation task previously shown to activate lateralized language areas in normal adults. Results-In 4 patients fTCD assessment was not possible because of lack of an acoustic temporal bone window. In the remaining 15 candidates, determination of language dominance was concordant with the Wada test in every case. Moreover, the correlation of the lateralization measures from both procedures was highly significant (rϭ.92, PϽ.0001). Conclusions-This strong correlation validates fTCD as a noninvasive and practical tool for the determination of language lateralization that can be applied for clinical and investigative purposes. (Stroke. 1998;29:82-86.)

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“…Modulations of CBFV are associated with equivalent regional cerebral blood flow changes as assessed by positron emission tomography (PET) (Sitzer et al 1994). With respect to temporal resolution, bilateral (i.e., multiarterial) TCD recordings are superior to presently available radio tracer-based imaging techniques, because TCD allows for continuous blood flow measurements.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Regional cerebral blood flow increases during preparation for and processing of sensory stimuli

Knecht¹,

Deppe²,

Bäcker³

et al. 1997

Exp Brain Res

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Preparing for and processing of sensory stimuli are energy-requiring processes. We attempted to assess the relative contributions of these processes to increases in regional cerebral perfusion. Nineteen healthy right-handed subjects were examined while they were engaged in detecting tactile stimuli to the index finger 5 s after a cueing tone. Cerebral blood flow velocity (CBFV) modulations in the middle cerebral arteries (MCAs) were continuously measured by bilateral simultaneous transcranial Doppler ultrasonography. Tactile stimuli well above threshold per se did not produce a significant, relative CBFV increase in the contralateral MCA. However, when subjects were expecting a threshold tactile stimulus, there was a significant regional increase in CBFV in the hemisphere contralateral to the attended index finger for approximately 15 s, starting within the first seconds after the cueing. This increase was present even before the tactile stimulus was applied and also in sessions when the stimulus was omitted. We conclude that preparation of the cortex causes a stronger regional cerebral blood flow increase than the processing of the tactile stimulus itself.

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Cerebral hemodynamics during sensorimotor activation in humans

Cited by 53 publications

References 0 publications

Active, passive, and motor imagery paradigms: component analysis to assess neurovascular coupling

Active, passive, and motor imagery paradigms: component analysis to assess neurovascular coupling

Noninvasive Determination of Language Lateralization by Functional Transcranial Doppler Sonography

Regional cerebral blood flow increases during preparation for and processing of sensory stimuli

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