Cerebral hemorrhage in Fabry's disease

Nakamura, Katsuya; Sekijima, Yoshiki; Nakamura, Kimitoshi; Hattori, Kiyoko; Nagamatsu, Kiyoshiro; Shimizu, Yoshifusa; Yasude, Takuji; Ushiyama, Masao; Endo, Fumio; Fukushima, Yoshimitsu; Ikeda, Shu Ichi

doi:10.1038/jhg.2010.18

Cited by 19 publications

(13 citation statements)

References 16 publications

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“…Microbleeds detected in this study were associated with white matter disease and deep gray matter involvement, suggesting that the same pathophysiology may lead to both: ischemic lesions and intracerebral hemorrhages in FD [24,36], and likely identifies patients with FD at higher risk for cerebral hemorrhage. Larger prospective studies of MRI in FD using GRE-weighted images are required to confirm our findings.…”

Section: Discussionmentioning

confidence: 84%

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Brain MRI findings in patients with Fabry disease

Reisin

Romero

Marchesoni

et al. 2011

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 84%

“…They were associated with hypertension in 68% of the patients, and affected the anterior circulation [5]. Previous reports on brain hemorrhages in FD are scarce and mostly associated to hypertension or end stage renal failure [21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Brain MRI findings in patients with Fabry disease

Reisin

Romero

Marchesoni

et al. 2011

Journal of the Neurological Sciences

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“…Although ischemic strokes and transient ischemic attacks are the most prevalent types of overt cerebrovascular events in FD, 10 cases of intracerebral hemorrhages, 11 subarachnoid hemorrhage, 12 microbleeds, 13 cerebral venous thrombosis, 14 and cervical carotid dissection 15 have also been reported. To our knowledge, no cases of vertebral dissection or spinal cord infarction have been documented in the literature to date.…”

Section: Cerebral Manifestations Of Fdmentioning

confidence: 99%

Cerebrovascular Involvement in Fabry Disease

Kolodny

Fellgiebel

Hilz

et al. 2015

Stroke

148

156

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“…The restraint in including bleedings in sifap1 might be also determined by the nature of the study, as cerebral haemorrhages are rarely accompanied by Fabry disease [15,16]. …”

Section: Discussionmentioning

confidence: 99%

Lessons from everyday stroke care for clinical research and vice versa: comparison of a comprehensive and a research population of young stroke patients

et al. 2014

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BackgroundTranslating knowledge derived from medical research into the clinical setting is dependent on the representativeness of included patients. Therefore we compared baseline data of patients included in a recent large study addressing young stroke in comparison to a large representative stroke registry.MethodsWe analysed baseline data of 5023 patients (age 18-55 years) with an acute cerebrovascular event included in the sifap1 (Stroke in Young Fabry Patients) study. For comparison 17007 stroke patients (age 18-55 years) documented (2004-2010) in a statutory stroke registry of the Institute of Quality Assurance Hesse of the Federal State of Hesse (GQH), Germany.ResultsAmong 17007 juvenile (18-55 years) patients identified in the GQH registry 15997 had an ischaemic stroke or TIA (91%) or an intracranial haemorrhage (9%). In sifap1 5023 subjects were included. Sex distribution was comparable (men: 59% sifap1 versus 60.5% GQH) whereas age differed between the groups: median age was 46 years in sifap1 versus 49 years in GQH. Slightly higher percentages for diabetes mellitus and hypertension in the GQH registry were noted. There were no differences in stroke severity as assessed by NIHSS (median 3) and mRS (median 2). In patients with ischaemic stroke or TIA (n = 4467 sifap1; n = 14522 GQH) higher rates of strokes due to small artery occlusion and atherosclerosis occurred in older age groups; cardioembolism and strokes of other determined cause occurred more frequently in younger patients.ConclusionsThe comparison of baseline characteristics between the sifap1 study and the GQH registry revealed differences mainly determined by age.

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Cerebral hemorrhage in Fabry's disease

Cited by 19 publications

References 16 publications

Brain MRI findings in patients with Fabry disease

Brain MRI findings in patients with Fabry disease

Cerebrovascular Involvement in Fabry Disease

Lessons from everyday stroke care for clinical research and vice versa: comparison of a comprehensive and a research population of young stroke patients

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