Cerebral infarct associated with factor V Leiden mutation in a boy with hemophilia A

Abstract

An 11-year-old boy with mild hemophilia A was admitted to our hospital because of focal convulsions. Magnetic resonance imaging showed an old occipital infarct. Protein C, S, antithrombin III, anticardiolipin antibodies and fibrinogen were normal. Heterozygosity for factor V Leiden mutation was detected. We suggest that factor V Leiden mutation should be studied in hemophiliacs with thrombosis.Am.

Transient thromboembolic event in a child with severe hemophilia a due to venous obstruction

“…Venous thrombosis is an important cause of hospital acquired morbidity and mortality [3]. It is associated rarely with patients of hemophilia A [1,2,[4][5][6][7]. Several risk factors have been described in medical literature.…”

“…Hemophilia A is a hereditary hemorrhagic disease characterized by deficiency of coagulation Factor VIII. Venous thrombosis in patients with hemophilia A has been rarely encountered in medical literature [1,2,[4][5][6][7] and it is an important cause of hospital acquired morbidity and mortality [3]. In this case report we present the onset of deep vein thrombosis in a one year old child with hemophilia A.…”

Deep vein thrombosis in a patient with severe haemophilia A

“…Occurrence of arterial or venous thrombosis in these patients is rare and would seem to be paradoxical to the underlying disease. Few cases of thrombotic events in patients with inherited coagulation disorders have been reported in the literature [1–5]. We describe a 25‐year‐old man with severe haemophilia A, who developed spontaneous deep vein thrombosis of the left upper limb in this case report.…”

Open heart surgery with mitral valve replacement - ordeal of an undiagnosed haemophilia patient.

“…Other reports have also shown that even patients with severe haemophilia are prone to the development of venous thrombosis after insertion of central venous catheters for prolonged periods (Blanchette et al ., 1996; Opanasenko & Voloshin; Journeycake et al ., 2001). There are a few reports of haemophilia patients with the FV Leiden mutation developing thrombosis (Olcay et al ., 1997; Purthi et al ., 2000). However, our patient had no thrombophilia markers.…”