2004
DOI: 10.1093/bja/aeh120
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Cerebral ischaemia during cardiac surgery in children detected by combined monitoring of BIS and near-infrared spectroscopy

Abstract: Children less than 4 yr of age are more likely to have cerebral ischaemia caused by hypotension during cardiac surgery. Ineffective cerebral autoregulation and haemodilution during CPB may be responsible.

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Cited by 97 publications
(64 citation statements)
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“…6,7 Recent studies have also examined the use of NIRS to measure the saturation of other tissues, including the intraperitoneal monitoring of pH in the small bowel, transcutaneous monitoring of lower abdominal perfusion indexed to cerebral perfusion in neonates with acute abdomen and transcutaneous monitoring of renal blood flow in neonates undergoing Norwood palliation. [8][9][10][11] This is the first report of monitoring post-ductal regional saturations with NIRS during surgical PDA ligation.…”
Section: Introductionmentioning
confidence: 99%
“…6,7 Recent studies have also examined the use of NIRS to measure the saturation of other tissues, including the intraperitoneal monitoring of pH in the small bowel, transcutaneous monitoring of lower abdominal perfusion indexed to cerebral perfusion in neonates with acute abdomen and transcutaneous monitoring of renal blood flow in neonates undergoing Norwood palliation. [8][9][10][11] This is the first report of monitoring post-ductal regional saturations with NIRS during surgical PDA ligation.…”
Section: Introductionmentioning
confidence: 99%
“…Bir diğer çalışmada, KAE olgularında klemp süresince, serebral hipoperfüzyona bağlı EEG ve BIS değerlerinde aynı anda düşme eğilimi saptanmıştır (21) . Pediatrik kardiyak cerrahi olgularında gelişen hipotansiyon, serebral kan akımının azalması ve serebral oksijen tüketiminin hızla değiştiği durumlarda BIS değerlerinin, serebral oksijen satürasyonu değerleriyle eşzamanlı azaldığı bildirilmiştir (13,14) . Serebral kan dolaşımının azalmasıyla sonuçlanan intrakraniyal hematom (9) ve kardiyak arrest gelişen olgularda BIS değerlerinde ani azalmalar tespit edilmiş ve bu olgularda BIS monitörü, kardiyak ressüsitasyon uygulaması sırasında serebral fonksiyonların geri dö-nüş takibi için de kullanılmıştır (22,23) .…”
Section: Discussionunclassified
“…Sedasyon ve bilinç düzeyi ile korelasyon gösteren özel ve kompleks bir EEG parametresi olan bispektral indeks (BIS) monitörü, ameliyat sırasında gelişebile-cek iskemik beyin hasarı tespiti için tasarlanmamış olmasına rağmen (8) , literatürde yetersiz beyin perfüz-yonuna bağlı BIS değerlerinde ani ve beklenmeyen azalmalar saptanan ve BIS değişikliklerinin nörolojik komplikasyonlarla ilişkilendirildiği olguların sunulduğu çeşitli çalışmalar mevcuttur (9)(10)(11)(12)(13)(14)(15) .…”
Section: Introductionunclassified
“…Some degree of neurological dysfunction is observed in 25 to 45% of children undergoing ECMO, 24 stemming from three main factors: systemic inflammatory response syndrome, micro and macroemboli, and insufficient cerebral blood flow to supply the metabolic needs, such as during episodes of hypertension or cardiorespiratory arrest. 25 The incidence of confirmed AIS in this situation ranges from 1 to 15%. The main conditions that cause brain injury are the systemic inflammation, microvasculopathy causing decreased cerebral blood flow, platelet aggregation through neutrophil activation and direct injury by oxygen free radicals through endothelial activation.…”
Section: Stroke and Cardiac Diseasesmentioning
confidence: 93%