2004
DOI: 10.1007/s10545-005-5518-0
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Cerebral ketone body metabolism

Abstract: Ketone bodies (KBs) are an important source of energy for the brain. During the neonatal period, they are also precursors for the synthesis of lipids (especially cholesterol) and amino acids. The rate of cerebral KB metabolism depends primarily on the concentration in blood; high concentrations occur during fasting and on a high-fat diet. Cerebral KB metabolism is also regulated by the permeability of the blood-brain barrier (BBB), which depends on the abundance of monocarboxylic acid transporters (MCT1). The … Show more

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Cited by 265 publications
(239 citation statements)
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“…In suckling rats, the more immature the cerebral cortex is, the more it uses ketone bodies, instead of glucose, as an energetic substrate. 17,18 Most patients in this study had cortical dysplasia with variable extent and severity, and we could not differentiate the efficacy of the diet therapy according to specific types of MCD. We were also unable to find a significant difference in seizure outcomes in specific types of lesions.…”
Section: Discussionmentioning
confidence: 87%
“…In suckling rats, the more immature the cerebral cortex is, the more it uses ketone bodies, instead of glucose, as an energetic substrate. 17,18 Most patients in this study had cortical dysplasia with variable extent and severity, and we could not differentiate the efficacy of the diet therapy according to specific types of MCD. We were also unable to find a significant difference in seizure outcomes in specific types of lesions.…”
Section: Discussionmentioning
confidence: 87%
“…amount of acetyl-CoA exceeds the capacity of the tricarboxylic acid cycle to utilize it, there is an increase in the production of the ketone bodies ␤ -hydroxybutyrate and acetoacetate, which can be used as an energy source in the brain (24)(25)(26)(27). While the mechanisms are not fully understood, the neuroprotective effects of a KD on the brain have led to interest in using it for the treatment of a host of neurological disorders including Alzheimer's disease, traumatic brain injury, and amyotrophic lateral sclerosis ( 28,29 ).…”
Section: Tumor Metabolismmentioning
confidence: 99%
“…Most studies in astrocyte ketogenesis come from cell culture experiments, and the extent of KB formation by astrocytes in vivo remains to be determined. Nevertheless, the major determinants of cerebral KB metabolism are the prevailing plasma KB concentrations and availability of suitable monocarboxylic acid transporter (MCT) isoforms ( 9 ).…”
Section: Physiology Of Ketogenesismentioning
confidence: 99%