Cerebral magnetic resonance changes associated with fibromyalgia syndrome

Murga, Íñigo; Guillén, Virginia; Lafuente, José Vicente

doi:10.1016/j.medcle.2017.05.011

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…Indeed, in 95% of cases, constant and diffuse pain is mainly localized in the limbs and torso 35,36 . Some Magnetic Resonance Imaging studies conducted to evaluate brain metabolism in patients with fibromyalgia were able to highlight the activation of the same brain areas triggered by painful stimuli (called "pain matrix") through the analysis of specific molecules such as N acetylaspartate, creatine, choline, lactate, myoinositol, glutamine and glutamate [37][38][39] .…”

Section: Discussionmentioning

confidence: 99%

Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity

Piras

Conte

Pibiri

et al. 2020

Sci Rep

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Fibromyalgia (FM) as Fibromyalgia and Electromagnetic Sensitivity (IEI-EMF) are a chronic and systemic syndrome. The main symptom is represented by strong and widespread pain in the musculoskeletal system. The exact causes that lead to the development of FM and IEI-EMF are still unknown. Interestingly, the proximity to electrical and electromagnetic devices seems to trigger and/or amplify the symptoms. We investigated the blood plasma metabolome in IEI-EMF and healthy subjects using 1H NMR spectroscopy coupled with multivariate statistical analysis. All the individuals were subjected to tests for the evaluation of psychological and physical features. No significant differences between IEI-EMF and controls relative to personality aspects, Locus of Control, and anxiety were found. Multivariate statistical analysis on the metabolites identified by NMR analysis allowed the identification of a distinct metabolic profile between IEI-EMF and healthy subjects. IEI-EMF were characterized by higher levels of glycine and pyroglutamate, and lower levels of 2-hydroxyisocaproate, choline, glutamine, and isoleucine compared to healthy subjects. These metabolites are involved in several metabolic pathways mainly related to oxidative stress defense, pain mechanisms, and muscle metabolism. The results here obtained highlight possible physiopathological mechanisms in IEI-EMF patients to be better defined.

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Section: Discussionmentioning

confidence: 99%

Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity

Piras

Conte

Pibiri

et al. 2020

Sci Rep

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“…A growing number of clinical studies, have demonstrated the efficacy of HBOT in improving pain and quality of life of fibromyalgia patients 14,15,[29][30][31][32] . Previous studies have shown that fibromyalgia is associated with decreased brain perfusion in the insula, hippocampus, putamen, prefrontal and cingulate cortex [33][34][35] . In the current study, these regions showed increased perfusion after HBOT.…”

Section: Brain Perfusionmentioning

confidence: 98%

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial

Zilberman-Itskovich

Catalogna

Sasson

et al. 2022

Sci Rep

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Post-COVID-19 condition refers to a range of persisting physical, neurocognitive, and neuropsychological symptoms after SARS-CoV-2 infection. The mechanism can be related to brain tissue pathology caused by virus invasion or indirectly by neuroinflammation and hypercoagulability. This randomized, sham-control, double blind trial evaluated the effect of hyperbaric oxygen therapy (HBOT or HBO2 therapy) on post-COVID-19 patients with ongoing symptoms for at least 3 months after confirmed infection. Seventy-three patients were randomized to receive daily 40 session of HBOT (n = 37) or sham (n = 36). Follow-up assessments were performed at baseline and 1–3 weeks after the last treatment session. Following HBOT, there was a significant group-by-time interaction in global cognitive function, attention and executive function (d = 0.495, p = 0.038; d = 0.477, p = 0.04 and d = 0.463, p = 0.05 respectively). Significant improvement was also demonstrated in the energy domain (d = 0.522, p = 0.029), sleep (d = − 0.48, p = 0.042), psychiatric symptoms (d = 0.636, p = 0.008), and pain interference (d = 0.737, p = 0.001). Clinical outcomes were associated with significant improvement in brain MRI perfusion and microstructural changes in the supramarginal gyrus, left supplementary motor area, right insula, left frontal precentral gyrus, right middle frontal gyrus, and superior corona radiate. These results indicate that HBOT can induce neuroplasticity and improve cognitive, psychiatric, fatigue, sleep and pain symptoms of patients suffering from post-COVID-19 condition. HBOT’s beneficial effect may be attributed to increased brain perfusion and neuroplasticity in regions associated with cognitive and emotional roles.

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“…Successful treatment options are limited and we believe this additional report on the efficacy of short-term hyperbaric oxygen is an important contribution to raise the awareness of HBOT as an effective treatment modality. associated with decreased brain perfusion in the insula, hippocampus, putamen, prefrontal and cingulate cortex [23][24][25]. Zilberman-Itskovich's study showed increased perfusion in these regions after HBOT and possibly this increased brain perfusion is responsible for the patients improvement in energy and neurocognition [14].…”

Section: Resultsmentioning

confidence: 98%

The Effect of Short-Term Hyperbaric Treatment on Long COVID Symptoms: A Pilot Study

Quinn,

Rami,

Martin J.

2023

Int J Sports Exerc Med

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Background: Long COVID has recently been recognized by the World Health Organization as a syndrome occurring two months after infection with Covid-19 with various physical, neurocognitive, and psychiatric symptoms that cannot be explained by another diagnosis. It is estimated that between six and twenty million patients in the United States alone are affected by this condition.Unfortunately, despite its prevalence, there is no established treatment regimen. The most widely prescribed therapies include respiratory care and physical therapy, cognitive therapy, and emotional support. Previous reports from the U.K. and Israel showed improvement in fatigue and brain fog following a regimen of Hyperbaric Oxygen Therapy (HBOT). The aim of this pilot study is to attempt to replicate the reported symptomatic improvement in long COVID patients with a short course of HBOT.Methods: Twelve patients were recruited via social media outlet to participate in a study investigating long COVID at a private outpatient hyperbaric facility. All patients had documented PCR COVID infection, had been diagnosed with long COVID by their primary care medical doctors and screened for contraindications to HBOT. Patients underwent ten 80-minute sessions of hyperbaric oxygen delivered via facemask at 100% oxygen at 2.0 ATM in a monoplace hyperbaric chamber. Patients were required to complete the 11-point Chalder Fatigue Scale as well as the Post Covid Functional Scale at baseline, five-session mark, and ten-session mark. The ten sessions had to be completed over a 2-week period.Results: Patients showed statistically significant improvement in both the Chalder Fatigue Scale as well as the Post Covid Functional Scale at the five and ten session marks post-treatment. There were no complications from treatment and all patients reported improvements in energy as well as cognition.Conclusions: This study confirms previous reports of the efficacy of HBOT as a treatment modality for patients suffering from long COVID. With estimates of 15% of all previously infected adults in the US having long COVID symptoms, this report emphasizes the efficacy of HBOT as a first line therapy for long COVID as well as highlights the need for large scale studies utilizing this modality.

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Cerebral magnetic resonance changes associated with fibromyalgia syndrome

Cited by 10 publications

References 36 publications

Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity

Metabolomics and psychological features in fibromyalgia and electromagnetic sensitivity

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial

The Effect of Short-Term Hyperbaric Treatment on Long COVID Symptoms: A Pilot Study

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