Cerebral Microbleeds Are Associated with Impairments in Executive Function and Processing Speed

Li, Xuanting; Yuan, Junliang; Qin, Wei; Yang, Lei; Yang, Shuna; Li, Yue; Hu, Wenli

doi:10.3233/jad-201202

Cited by 8 publications

(10 citation statements)

References 36 publications

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“…In this study, the combined protocol of various DT tests and single tasks was used to describe the feature of cognitive performances on DT of CMB patients. The results showed that the global cognitive function of CMB patients was worse than that of subjects without CMB, which was consistent with previous studies (Akoudad et al, 2016 ; Li et al, 2021a ). Compared to subjects without CMB, CMB patients had worse cognitive performances on the DT condition in CRR of WSS, WSF and TUGSS, and DTE of WSS.…”

Section: Discussionsupporting

confidence: 92%

“…Cerebral microbleed (CMB) is one of the crucial markers of CSVD, and its pathological mechanism is closely related to hypertension and cerebral amyloid angiopathy (Shuaib et al, 2019 ). Many studies have indicated that CMB is associated with the cognitive impairment or gait dysfunction (Akoudad et al, 2016 ; Chiu et al, 2018 ; Nyúl-Tóth et al, 2020 ; Li et al, 2021a ; Sullivan et al, 2021 ). However, there are no studies specifically focusing on the effect of CMB lesions on DT performances.…”

Section: Introductionmentioning

confidence: 99%

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Cerebral Microbleeds Were Related With Poor Cognitive Performances on the Dual Task Condition in Older Adults

Yang

Qin

et al. 2022

Front. Aging Neurosci.

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Background: The dual task (DT) was commonly used to assess the risk of falls in older adults and patients with neurological disorders. However, the performance on DT conditions has not been well investigated in patients with cerebral microbleed (CMB). This study is aimed to compare the performance in DT tests between older adults with and without CMB, and to explore the association between CMB and cognitive performances of DT.Methods: This is a cross-sectional study. A total of 211 old adults participated, involving 68 CMB patients. The task protocol involved two global cognition tests, two single cognitive tests (serial 7 subtraction and semantic fluency), two single motor tasks [8-m walking and timed up and go test (TUG)], and three DT tests [walking and serial subtraction (WSS), walking and semantic fluency (WSF), and TUG and serial subtraction (TUGSS)]. The time taken to complete each task and the number of correct responses were recorded. For each DT condition, the correct response rate (CRR) and the dual-task effect (DTE) for the correct number were calculated.Results: Compared with subjects without CMB, CMB patients had worse cognitive performances on DT condition in CRR of WSS (p = 0.003), WSF (p = 0.030) and TUGSS (p = 0.006), and DTE of WSS (p = 0.017). Binary logistic regression analysis showed that the presence of CMB was an independent risk factor for the impairment group for CRR of TUGSS (OR, 2.54; 95% CI, 1.11–5.82; p = 0.027) with the adjustment for confounders, rather than CRR of WSS and WSF, or DTE of WSS. Multiple linear regression analysis showed that CRR of TUGSS decreased with the increase of CMB number grades (β, −0.144; 95% CI, −0.027, −0.002; p = 0.028).Conclusion: The present study indicated that CMBs were closely associated with poor cognitive performances on DT in the elderly. Strongest effect size was seen for CRR of TUGSS, where performance deficits increased in proportion to the degree of CMB burden.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Cerebral Microbleeds Were Related With Poor Cognitive Performances on the Dual Task Condition in Older Adults

Yang

Qin

et al. 2022

Front. Aging Neurosci.

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“… 43 However, Barnaure et al 44 found that the location and severity of CMBs were not related to cognitive function scores; this may be because that the participants in that study were older patients and the methods for measuring cognitive function were different from those in other studies. Moreover, Li et al 6 hold that multiple microbleeds were shown to be associated with low cognitive scores and poor results in specific areas of cognitive assessment, including overall cognitive function, and these findings are similar to our own. This may be related to the local or extensive damage in the functional area of the brain.…”

Section: Discussionsupporting

confidence: 92%

“… 4 Based on large-scale population studies, the prevalence of CMBs has reached 7–25%, 5 which is associated with overall cognitive impairment in all test domains, especially in reducing orientation, dependence on executive function, attention, numeracy, and delayed recall. 3 , 6 …”

Section: Introductionmentioning

confidence: 99%

Plasma Lipoprotein-Associated Phospholipase A2 Affects Cognitive Impairment in Patients with Cerebral Microbleeds

Liu¹,

Zhang²,

Jiang³

et al. 2023

NDT

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Purpose The plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker of cerebral microbleeds (CMBs) and may be related to the occurrence, development, and prognosis of cognitive impairment. The present study aimed to investigate the impact of plasma Lp-PLA2 level on the cognitive impairment in patients with CMBs. Methods In this study, 213 patients with CMBs confirmed by 3.0 T brain magnetic resonance imaging (MRI) were analyzed. Lp-PLA2 levels were determined by magnetic particle chemiluminescence immunoassay technology, and cognitive function was assessed using the Montreal Cognitive Assessment Scale (MoCA). The cognitive functions of patients with CMBs were divided into three groups according to the MoCA scale, including normal cognition (NC), mild cognitive impairment (MCI), and moderate-severe cognitive impairment (MSCI). Clinical, laboratory and radiological data of the three groups were analysed. The relationship between plasma Lp-PLA2 and MoCA score in patients with CMBs was investigated through rank correlation analysis and multivariate regression analysis, and receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of Lp-PLA2. Results CMBs were detected in 213 (30.2%) of 705 patients who underwent 3.0 T MRI. Multiple comparisons showed that plasma Lp-PLA2 in patients with CMBs with normal cognitive scores was significantly lower than that in the other two groups with cognitive impairment ( p < 0.05). In the single factor correlation analysis, high level of plasma Lp-PLA2 was negatively correlated with the decrease of MoCA score in patients with CMBs ( r =−0.389, p < 0.01). Multivariate regression analysis showed that high plasma Lp-PLA2 was an independent risk factor for a low MoCA score in patients with CMBs (odds ratio [OR]=1.014; 95% confidence interval [CI], 1.002–1.026; p =0.025). Conclusion A high level of plasma Lp-PLA2 is positively correlated with the generation of cognitive impairment in patients with CMBs and negatively correlated with the degree of impairment. Plasma Lp-PLA2 is an important indicator of cognitive impairment in patients with CMBs and may provide a therapeutic target for preventing CMB-induced cognitive impairment.

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“…In addition to their role as markers of an underlying disease, growing evidence has demonstrated that CMBs could have direct effects on neurologic function, cognition, and disability (18)(19)(20)(21). Evidence shows the association of CMBs with impairments in executive function and processing speed (22,23). Indeed, neuropathological analyses of CMBs generally find these lesions to be associated with some degree of surrounding tissue damage offering a potential mechanism for brain dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Presence of cerebral microbleeds is associated with cognitive decline in acromegaly

Xie

Zhou

Zhang³

et al. 2022

Front. Oncol.

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BackgroundCognitive decline in acromegaly has gained increasing attention. Cerebral microbleeds (CMBs) as radiographic markers for microvascular injury have been linked to various types of cognitive decline. However, the association between CMB formation and acromegaly has not yet been quantified. This study is designed to investigate the prevalence and the radiographic patterns of CMBs and the association between cognitive function and acromegaly-related CMBs in growth hormone (GH)-secreting pituitary adenoma, which is characterized by acromegaly. MethodsIn a cohort of 55 patients with GH-secreting pituitary adenoma (acromegaly) and 70 healthy control (HC) patients, we determined the presence of CMBs using a 3.0-T MRI scanner. The numbers, locations, and grades of CMBs were determined via susceptibility-weighted imaging (SWI) and the Microbleed Anatomical Rating Scale. Obstructive sleep apnea (OSA) was assessed using the criteria of the American Academy of Sleep Medicine (AASM) Scoring Manual Version 2.2. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive performance within 3 days of admission. The association between CMBs and cognitive function as well as clinical characteristics was explored.ResultsThe incidence of CMBs was 29.1%, whereas that of OSA was 65.5% in acromegaly. There was a statistically significant difference in the prevalence of CMBs between subjects with and without acromegaly (29.1% and 5.3%, respectively) (p < 0.01). The age of acromegaly patients with CMBs was much younger compared with HCs with CMBs. Compared with HCs, a significant cognitive decline and the occurrence of OSA were demonstrated in patients with acromegaly (p < 0.01). Binary logistic regression analysis adjusted for age, education, and body mass index (BMI) revealed that CMB was an independent risk factor for cognitive impairment in patients with acromegaly (OR = 3.19, 95% CI 1.51–6.76, p = 0.002). Furthermore, in the logistic regression models adjusted for age, BMI, diabetes, and hypertension, OSA was independently associated with the occurrence of CMBs in patients with acromegaly (OR = 13.34, 95% CI 3.09–57.51, p = 0.001).ConclusionsA significant increase of CMBs was demonstrated in patients with acromegaly, which may be a result of OSA in acromegaly. The present study indicated that increasing CMBs are responsible for cognitive decline in patients with acromegaly.

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Cerebral Microbleeds Are Associated with Impairments in Executive Function and Processing Speed

Cited by 8 publications

References 36 publications

Cerebral Microbleeds Were Related With Poor Cognitive Performances on the Dual Task Condition in Older Adults

Cerebral Microbleeds Were Related With Poor Cognitive Performances on the Dual Task Condition in Older Adults

Plasma Lipoprotein-Associated Phospholipase A2 Affects Cognitive Impairment in Patients with Cerebral Microbleeds

Presence of cerebral microbleeds is associated with cognitive decline in acromegaly

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