Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease

Abstract

Asymptomatic Aβ deposition in older adults is strongly associated with LMH.

Prevalence and Topography of Small Hypointense Foci Suggesting Microbleeds on 3T Susceptibility-Weighted Imaging in Various Types of Dementia

“…Therefore, we think that the effect of small-vessel disease in our patients with subjective complaints was small. The prevalence of lobar SHF among elderly healthy controls with a mean age of 74.6 years reported by Yates et al, 21 who used 3T SWI, was similar to ours. The mean age of our patients with subjective complaints was slightly lower than theirs.…”

“…8 Deep subcortical SHF are thought to be associated with vascular risk factors, 11 and lobar SHF are usually attributed to vascular ␤-amyloid deposits (cerebral amyloid angiopathy). 11,[19][20][21] Among patients with cognitive disorders, those with AD, MCI, and VaD tend to have SHF. 22 In healthy subjects, the prevalence of SHF detected by 2D T2*-weighted GRE imaging ranged from 0% to 21% 14,23,24 ; it increased to 32% in patients with AD, 25 to 20%…”

“…26 Although histologic studies found a relatively high prevalence of microhemorrhages in the brains of patients with DLB at postmortem examination, 27 no MR imaging studies examining SHF in patients with DLB have been reported. Although there are a few studies of SHF detected on SWI of control subjects and patients with the limited type of dementia, 21,28 no cohort studies have evaluated the prevalence and topography of SHF on 3T SWI in various types of dementia. The purpose of this study was to investigate the prevalence and topography of SHF on 3T SWI in patients with different dementia subtypes.…”

The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies

“…159 Finally, cerebral microhemorrhages (which are associated with several vascular risk factors) have been positively associated with amyloid deposition in the parieto-occipital region in a study of healthy older adults and patients with MCI or dementia. 160 Overall, findings from in vivo amyloid imaging reinforce the relationship between AD and CVRFs. Further longitudinal studies should address in greater depth the relationship between CVRFs and Ab deposition in the brain, using PET for amyloid imaging.…”

Focal Ab-amyloid deposition precedes cerebral microbleeds and Superficial siderosis: a case report

“…At that stage, her MMSE was 22/30 with a CDR of 1.0; there were still no focal neurological signs and blood tests were normal. In April 2009, after her second set of MRIs and before her next 11 C-PiB or neuropsychological evaluation, she was withdrawn from the study by her husband. The demographic information of the subject along with memory scores and quantitative imaging measures at different time-points are summarized in table 1.…”