Cerebral Microvascular Dysfunction and Inflammation Are Improved by Centrally Acting Antihypertensive Drugs in Metabolic Syndrome

Abstract

Our results suggest that central sympathetic inhibition exerts beneficial effects by increasing perfusion and reducing inflammatory marker expression and oxidative stress in the brains of rats with metabolic syndrome. Centrally acting antihypertensive drugs may be helpful in regulating cerebral microcirculatory function and vascular inflammation in metabolic syndrome.

Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II‐induced microcirculatory changes in a model of primary hypertension

“…Using laser speckle contrast imaging (LSCI), we assessed changes in relative mCBF and microvascular reactivity to Ach and Ang II. Recently, LSCI, a label‐free microvascular angiography, has been described as a valuable approach to evaluate the cortical blood flow and microvascular reactivity in clinical and experimental studies . A limitation of the study is that LSCI does not precisely relate speckle contrast measurements to absolute blood flow, as LSCI two‐dimensional scanning mode is limited to measure relative blood flow.…”

“…Recently, LSCI, a label-free microvascular angiography, has been described as a valuable approach to evaluate the cortical blood flow and microvascular reactivity in clinical and experimental studies. [65][66][67] A limitation of the study is that LSCI does not precisely relate speckle contrast measurements to absolute blood flow, as LSCI two-dimensional scanning mode is limited to measure relative blood flow. However, LSCI was described as suitable for the characterization of CBF changes in response to several physiological and pharmacological stimuli in rodents.…”

Exercise training dose differentially alters muscle and heart capillary density and metabolic functions in an obese rat with metabolic syndrome

“…Moreover, microvascular rarefaction is present in the cerebral cortex in the obese rat model of metabolic syndrome (Estato et al . ). These previous observations may have an important impact on the patterns of blood flow within the skeletal muscle microcirculation, contributing to the elevation of peripheral vascular resistance and to an increase in the number of cardiovascular deaths (Greene et al .…”

Human Metabolism: A Regulatory Perspective

“…The rarefaction can be structural, characterised by the absence of capillaries, or functional, in which capillaries are present but they are not perfused. There are currently several pieces of evidence that MS is directly involved with both structural and functional capillary rarefaction in the skeletal muscle, heart and brain (Nascimento et al, 2013;Estato et al, 2017;Machado et al, 2014;Machado et al, 2016).…”