Cerebral near-infrared spectroscopy analysis in preterm infants with intraventricular hemorrhage

Zhang, Ying; Grace, Clare; Tracy, Mark; Lee, Qim Y; Hinder, Murray; Savkin, Andrey V.; Lovell, Nigel H.

doi:10.1109/iembs.2011.6090547

Cited by 6 publications

(9 citation statements)

References 14 publications

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“…Intraventricular hemorrhage has been associated with both lower [21] and higher cerebral oxygenation in previous studies [22,23].…”

Section: Discussionmentioning

confidence: 79%

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Cerebral Oxygenation during Neonatal Intubation with Nasal High Flow: A Sub-Study of the SHINE Randomized Trial

Van Der Veeken,

Manley,

Owen

et al. 2023

Neonatology

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Introduction: Nasal high flow (nHF) improves the likelihood of successful neonatal intubation on the first attempt without physiological instability. The effect of nHF on cerebral oxygenation is unknown. The aim of this study was to compare cerebral oxygenation during endotracheal intubation in neonates receiving nHF and those receiving standard care. Methods: A sub-study of a multicentre randomized trial of nHF during neonatal endotracheal intubation. A subset of infants had near-infrared spectroscopy (NIRS) monitoring. Eligible infants were randomly assigned to nHF or standard care during the first intubation attempt. NIRS sensors provided continuous regional cerebral oxygen saturation (rScO2) monitoring. The procedure was video recorded, and peripheral oxygen saturation and rScO2 data were extracted at 2-second intervals. The primary outcome was the average difference in rScO2 from baseline during the first intubation attempt. Secondary outcomes included average rScO2 and rate of change of rScO2. Results: Nineteen intubations were analyzed (11 nHF; 8 standard care). Median (interquartile range [IQR]) postmenstrual age was 27 (26.5–29) weeks, and weight was 828 (716–1,135) g. Median change in rScO2 from baseline was −1.5% (−5.3 to 0.0) in the nHF group and −9.4% (−19.6 to −4.5) in the standard care group. rScO2 fell more slowly in infants managed with nHF compared with standard care: median (IQR) rScO2 change −0.08 (−0.13 to 0.00) % per second and −0.36 (−0.66 to −0.22) % per second, respectively. Conclusions: In this small sub-study, regional cerebral oxygen saturation was more stable in neonates who received nHF during intubation compared with standard care.

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“…Intraventricular hemorrhage has been associated with both lower [21] and higher cerebral oxygenation in previous studies [22,23].…”

Section: Discussionmentioning

confidence: 79%

“…Several factors may have contributed to this: the baseline SpO 2 for the infant was very low (65%); additionally, the infant had a large intraventricular hemorrhage diagnosed prior to the intubation. Intraventricular hemorrhage has been associated with both lower [21] and higher cerebral oxygenation in previous studies [22, 23].…”

Section: Discussionmentioning

confidence: 96%

Cerebral Oxygenation during Neonatal Intubation with Nasal High Flow: A Sub-Study of the SHINE Randomized Trial

Van Der Veeken,

Manley,

Owen

et al. 2023

Neonatology

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“…Blood pressure was measured invasively with an indwelling catheter in 27 [ 21 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ] studies and non-invasively with oscillometric measurements in 3 studies [ 22 , 49 , 50 ]. In five studies [ 51 , 52 , 53 , 54 , 55 ], both methods were combined, and in one study [ 56 ], the method was unclear.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies were conducted 24 h after birth [ 23 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ] ( Table 3 ). Three studies examined the physiological changes in blood pressure, cerebral tissue oxygenation, and cerebral autoregulation [ 46 , 47 , 48 ], and a further two studies [ 43 , 45 ] investigated cerebral autoregulation in stable and sick neonates by combining cerebral tissue oxygenation with blood pressure measurement.…”

Section: Resultsmentioning

confidence: 99%

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Insights into Neonatal Cerebral Autoregulation by Blood Pressure Monitoring and Cerebral Tissue Oxygenation: A Qualitative Systematic Review

Pfurtscheller,

Baik-Schneditz,

Schwaberger

et al. 2023

Children

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Objective: The aim of this qualitative systematic review was to identify publications on blood pressure monitoring in combination with cerebral tissue oxygenation monitoring during the first week after birth focusing on cerebral autoregulation. Methods: A systematic search was performed on PubMed. The following search terms were used: infants/newborn/neonates, blood pressure/systolic/diastolic/mean/MAP/SAP/DAP, near-infrared spectroscopy, oxygenation/saturation/oxygen, and brain/cerebral. Additional studies were identified by a manual search of references in the retrieved studies and reviews. Only human studies were included. Results: Thirty-one studies focused on preterm neonates, while five included preterm and term neonates. In stable term neonates, intact cerebral autoregulation was shown by combining cerebral tissue oxygenation and blood pressure during immediate transition, while impaired autoregulation was observed in preterm neonates with respiratory support. Within the first 24 h, stable preterm neonates had reduced cerebral tissue oxygenation with intact cerebral autoregulation, while sick neonates showed a higher prevalence of impaired autoregulation. Further cardio-circulatory treatment had a limited effect on cerebral autoregulation. Impaired autoregulation, with dependency on blood pressure and cerebral tissue oxygenation, increased the risk of intraventricular hemorrhage and abnormal neurodevelopmental outcomes. Conclusions: Integrating blood pressure monitoring with cerebral tissue oxygenation measurements has the potential to improve treatment decisions and optimizes neurodevelopmental outcomes in high-risk neonates.

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Effects of sodium bicarbonate correction of metabolic acidosis on regional tissue oxygenation in very low birth weight neonates

et al. 2015

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NaHCO3 infusions decreased base deficits and increased pH though produced no discernible effects or benefits on cardiopulmonary parameters including rSO2 and FTOE. These findings warrant further prospective evaluation in larger populations with more significant metabolic acidosis to determine the utility of tissue oxygenation monitoring in differentiating metabolic acidosis due to oxygen delivery/consumption imbalance versus renal bicarbonate losses.

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Cerebral near-infrared spectroscopy analysis in preterm infants with intraventricular hemorrhage

Cited by 6 publications

References 14 publications

Cerebral Oxygenation during Neonatal Intubation with Nasal High Flow: A Sub-Study of the SHINE Randomized Trial

Cerebral Oxygenation during Neonatal Intubation with Nasal High Flow: A Sub-Study of the SHINE Randomized Trial

Insights into Neonatal Cerebral Autoregulation by Blood Pressure Monitoring and Cerebral Tissue Oxygenation: A Qualitative Systematic Review

Effects of sodium bicarbonate correction of metabolic acidosis on regional tissue oxygenation in very low birth weight neonates

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