Cerebral neurovascular alterations in stable chronic obstructive pulmonary disease: a preliminary fMRI study

Peng, Zhongmin; Zhang, Hong Tao; Wang, Gang; Zhang, Juntao; Qian, Shaowen; Zhao, Yajun; Zhang, Ruijie; Wang, Wei

doi:10.7717/peerj.14249

Cited by 3 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes may be caused by various factors such as chronic hypoxia, mitochondrial dysfunction, and alterations in neurovascular coupling. Chronic hypoxia can trigger compensatory mechanisms, including angiogenesis, which may increase cortical surface area [ 17 , 49 ]. Additionally, oxidative stress in COPD may lead to mitochondrial dysfunction in brain cells, resulting in cell swelling [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, oxidative stress in COPD may lead to mitochondrial dysfunction in brain cells, resulting in cell swelling [ 50 , 51 ]. Furthermore, studies have shown that the relationship between neural activity and cerebral blood flow is disrupted in COPD patients, and this abnormal neurovascular coupling may contribute to cortical changes [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study

Fang,

Li,

2024

BMC Pulm Med

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) has been associated with alterations in the brain cortical structure. Nonetheless, the causality between COPD and brain cortical structure has not been determined. In the present study, we used Mendelian randomization (MR) analysis to explore the causal effects of genetic predicated COPD on brain cortical structure, namely cortical surface area (SA) and cortical thickness (TH). Genetic association summary data for COPD were obtained from the FinnGen consortium (N = 358,369; Ncase = 20,066). PRISm summary genetic data were retrieved from a case–control GWAS conducted in the UK Biobank (N = 296,282). Lung function indices, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC, were extracted from a meta-analysis of the UK Biobank and SpiroMeta consortium (N = 400,102). Brain cortical structure data were obtained from the ENIGMA consortium (N = 51,665). Inverse-variance weighted (IVW) method was used as the primary analysis, and a series of sensitivity tests were exploited to evaluate the heterogeneity and pleiotropy of our results. The results identified potential causal effects of COPD on several brain cortical specifications, including pars orbitalis, cuneus and inferior parietal gyrus. Furthermore, genetic predicated lung function index (FEV1, FVC and FEV1/FVC), as well as PRISm, also has causal effects on brain cortical structure. According to our results, a total of 15 functional specifications were influenced by lung function index and PRISm. These findings contribute to understanding the causal effects of COPD and lung function to brain cortical structure.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study

Fang,

Li,

2024

BMC Pulm Med

View full text Add to dashboard Cite

show abstract

Utilizing Siamese 4D-AlzNet and Transfer Learning to Identify Stages of Alzheimer’s Disease

Mehmood,

Shahid,

Khan

et al. 2024

Neuroscience

View full text Add to dashboard Cite

Causal effects of lung function on brain cortical structure and subcortical structure: a two-sample univariate and multivariate Mendelian randomization study

Shao,

You,

Huang

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Lung function has been increasingly linked to overall health, including brain health, prompting the investigation into the causal relationships between lung function and brain structures. This study employs Mendelian Randomization (MR) to explore these causal relationships, leveraging genetic variants as proxies to predict the effects of lung function on brain cortical and subcortical structures. Methods We conducted univariate and multivariable MR analyses using GWAS summary statistics for lung function (FEV1, FVC, FEV1/FVC) and brain structures from the UK Biobank and ENIGMA consortium. Our analyses included five MR methods—IVW, MR-Egger, weighted median, weighted mode, and simple mode—to ensure robust causal inference. Multivariable MR (MVMR) analyses were performed to adjust for potential confounders like smoking and education. Sensitivity analyses were performed to confirm the stability of our results, and we applied FDR correction for multiple comparisons. Results The univariate MR analysis revealed significant associations between lung function and brain structures. Higher FEV1 was associated with increased global cortical volume (β = 4428.037, SE = 610.453, p < 0.0001) and supramarginal thickness (β = 43.613, SE = 13.218, p = 0.001). FVC was similarly associated with increased global cortical volume (β = 3650.674, SE = 576.736, p < 0.0001) and parsopercularis thickness (β = 0.013, SE = 0.003, p < 0.0001). Multivariable MR confirmed these associations, even after adjusting for smoking and education. Significant associations persisted in subcortical regions, with higher FEV1 and FVC linked to increased brainstem volume (FEV1: β = 0.226, SE = 0.049, p < 0.0001; FVC: β = 0.203, SE = 0.044, p < 0.0001) and amygdala volume for FEV1/FVC (β = 0.075, SE = 0.025, p = 0.003). Sensitivity and pleiotropy analyses indicated no significant heterogeneity or horizontal pleiotropy, confirming the robustness of the results. Conclusion Our study provides robust evidence of a causal relationship between lung function and brain structure, emphasizing the protective effects of better respiratory health on brain integrity. However, the reliance on European GWAS data limits generalizability, and some associations did not survive stringent correction. Future research should incorporate diverse populations and explore underlying mechanisms to validate and extend these findings.

show abstract

Cerebral neurovascular alterations in stable chronic obstructive pulmonary disease: a preliminary fMRI study

Cited by 3 publications

References 49 publications

COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study

COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study

Utilizing Siamese 4D-AlzNet and Transfer Learning to Identify Stages of Alzheimer’s Disease

Causal effects of lung function on brain cortical structure and subcortical structure: a two-sample univariate and multivariate Mendelian randomization study

Contact Info

Product

Resources

About