Cerebral oedema and increased intracranial pressure in chronic liver disease

Identification of Minimal Hepatic Encephalopathy in Patients with Cirrhosis Based on White Matter Imaging and Bayesian Data Mining

“…Brain edema has been reported to be fatal, especially in highgrade HE, due to increased intracranial pressure. 37,38 Moreover, our findings regarding the predictive values of MD and FA on survival agree with the consensus that brain edema [9][10][11] and structural impairment 12,13 progress with advanced disease. One strength of this study is the application of an advanced machine-learning method, GAMMA, to the detection of MHErelated biomarkers.…”

Medical Therapy of Brain Edema in Fulminant Hepatic Failure

“…Overt brain edema with intracranial hypertension has been reported in patients with cirrhosis and deep coma. 20,21 How has this knowledge on astrocyte swelling translated into newer therapeutic developments? Selective inhibition of brain glutamine synthetase is still not available in the clinical realm.…”

The Last Gasp Or Caveat Cenans !

“…In FHF, the decline into stages III and IV coma usually signifies the development of cerebral edema and intracranial hypertension, which are otherwise truly exceptional in patients with chronic liver disease. 30 The clinical similarity of the encephalology of chronic liver disease and early FHF accounts for the confounding of these distinct entities (which may also share some pathogenic mechanisms 31 ) as remarked upon earlier. Some investigators advocate subdividing FHF into hyperacute, acute, and subacute (subfulminant) stages based on the relationship of the time course of the disease to outcome, 32 but this has yet to gain widespread acceptance.…”