Cerebral Palsy Among Term and Postterm Births

Moster, Dag; Wilcox, Allen J.; Vollset, Stein Emil; Markestad, Trond; Lie, Rolv Terje

doi:10.1001/jama.2010.1271

Cited by 136 publications

(102 citation statements)

References 34 publications

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“…Finally 11 eligible studies were included and the selection process is detailed in figure 1. Characteristics of the 11 studies are summarized in table 1 and quality assessment is presented in table 2[11,13,14,15,16,17,18,19,20,21,22]. None of the 11 studies focused solely on ETIs, and all of them included a subgroup of infants born at 37–38 gestational weeks within the study population.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Long-Term Development of Early Term Infants

Dong

Chen

2012

Neonatology

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Background: Births between 37 0/7 and 38 6/7 weeks of gestation are newly defined as early term infants (ETIs), and are increasingly considered to be at higher risk of adverse outcomes than infants born at 39–41 weeks’ gestation. To date, the long-term development of ETIs has not been systematically reviewed. Objective: To assess the effect of being born early term on long-term developmental outcomes. Methods: The literature of MEDLINE, EMBASE, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials, and abstracts from the Society of Pediatric Research were searched. If two or more studies regarding the same outcome were retrieved, a meta-analysis was conducted by RevMan 5. A sensitivity analysis was performed to assess the heterogeneity. Results: Eleven studies involving 4 categories of long-term development were included. Compared with infants born at 39–41 weeks’ gestation, ETIs had poorer outcomes in school performance, neurodevelopment, behavior and emotional status and long-term social outcomes. Meta-analyses showed that being born early term significantly increased the risk of cerebral palsy [relative risk, RR, 1.75 (95% confidence interval, CI, 1.32, 2.31)] and mathematical difficulties [RR 1.13 (95% CI 1.04, 1.21)]. The statistical test of heterogeneity for cerebral palsy was significant. Sensitivity analysis demonstrated that variations in follow-up periods were associated with heterogeneity. Conclusion: Emerging evidence suggests that ETIs are at risk of adverse long-term outcomes. Due to paucity and heterogeneity of the existing data, future research is needed to clarify the long-term risk of being born early term.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review and Meta-Analysis of Long-Term Development of Early Term Infants

Dong

Chen

2012

Neonatology

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“…Despite considerable advances in medical care of affected infants, the overall incidence of CP has remained unchanged within the recent decades (3,4). This clinical event could limit children's daily functional abilities and disturb their health-related quality of life, and lead to death in case of deterioration of clinical conditions as well as appearing concurrent clinical complications, such as neurological, cardiovascular, or respiratory complications (5,6). Furthermore, this disability could be accompanied by mental retardation because of reduced oxygen and also further decrease of supply to neural pathways and neuronal structure (7).…”

Section: Introductionmentioning

confidence: 99%

A Review on Stem Cell Therapy in Cerebral Palsy with a Focus on Motor Function Improvement

et al. 2018

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The current knowledge on how to use stem cells therapeutically for improving motor function in patients with cerebral palsy is growing. The present review aimed at assessing clinical trials related to beneficial effects of stem cells in patients with cerebral palsy. Electronic searches including "stem cell" and "cerebral palsy" as keywords were conducted using PubMed, Ovid, Web of Science, Scopus, Cochrane library, and CINAHL till February 2016. Two assessors reviewed the methodological quality and eligibility of the retrieved articles, independently. Among 77 studies initially reviewed based on the keywords, only 6 clinical trials were identified that met the inclusion criteria. Pooled response rate of stem cell therapy to treat cerebral palsy was estimated by assessing the percentage of improvement with a gross motor function classification system score. The resulting pooled estimate indicated a 30.7% (95% CI: 25.80% to 35.69%) increase in the score, 1 to 6 months after cell transplantation. In this regard, the test for heterogeneity was statistically significant (I2 = 87.9%, χ 2 = 41.22, P < 0.0001). Stem cell therapy has the potential to improve motor function in patients with cerebral palsy. However, promising results from limited studies warrant further research.

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“…The long-term effects of postterm birth are unclear, but may include neurologic risks such as epilepsy and cerebral palsy (9,10).…”

Section: Introductionmentioning

confidence: 99%

“…Maternal risks of postterm pregnancy include an increased frequency of failed induction, 3rd and 4rd degree perinea lacerations, infection, and postpartum hemorrhage (9)(10)(11)(12). Management of pregnant mothers with no onset of labor ranges from expectant management consisting of intensive monitoring of mother and fetus to inCopyright © 2017, Iranian Society of Pediatrics.…”

Section: Introductionmentioning

confidence: 99%

The Comparison of Perinatal Outcomes in Early Delivery Versus Postdate Labor

et al. 2017

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Background: Prenatal mortality and morbidity increase after 40 weeks of gestation. The current study aimed at comparing maternal and neonatal outcomes between term and postterm pregnancies. Methods: The current prospective cohort study was performed on 1180 singleton, cephalic fetus, and uncomplicated pregnancy cases admitted for labor. Pregnant mothers were divided into 3 groups. Group 1 included 750 cases in 38 to 40 weeks, group 2 included 250 cases in 40 to 41 weeks, and group 3 included 180 cases in over 41 weeks of gestation. Prenatal outcomes were recorded as: fetal distress, meconium passage, meconium aspiration, fetal weight ≥ 4 kg, Apgar score in 1 and 5 minutes, neonatal intensive care unit (NICU) admission, maternal infection, postpartum hemorrhage, and the rate of cesarean section. Results: There were significant differences in the rate of fetal distress (P < 0.001), meconium passage (P = 0.001), meconium aspiration syndrome (P < 0.001), Apgar score ≤ 3 at 1 (P = 0.025) and 5 minutes (P < 0.001), admission to NICU (P < 0.001), rate of cesarean section (P < 0.001), and maternal infection (P = 0.001) among the groups. The frequency of fetal distress was lower in group1 compared with group 2 (1.6% versus 4.4%; P = 0.011). Also fetal distress was significantly lower in group 1 than group 3 (1.6% versus 10.9%; P < 0.001). The meconium passage and meconium aspiration syndrome were statistically lower in group 1 compared with group 2 (1.6% versus 8%; P < 0.001 for meconium passage, and 0.9% versus 5.6%; P < 0.001 for meconium aspiration syndrome). Also meconium passage and meconium aspiration syndrome were significantly lower in group 1 compared with group 3 (1.6% versus 13.9%; P < 0.001 for meconium passage, and 0.9% versus 10%; P < 0.001 for meconium aspiration syndrome). The cesarean section was more frequent in group 2 compared with group 1 (24.8% versus 13.6%; P < 0.001) and in group 3 compared with group 1 (33.3% versus 13.6%, P < 0.001). There was no significant difference in the mean fetal weight, fetal weight ≥ 4 kg, and postpartum hemorrhage in females between the 3 groups. Conclusions: Late-term and postterm births are associated with higher rates of fetal and neonatal morbidity and maternal risks compared to pregnancy termination before 40 weeks of gestation, and earlier birth induction is recommended in such cases.

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Cerebral Palsy Among Term and Postterm Births

Cited by 136 publications

References 34 publications

A Systematic Review and Meta-Analysis of Long-Term Development of Early Term Infants

A Systematic Review and Meta-Analysis of Long-Term Development of Early Term Infants

A Review on Stem Cell Therapy in Cerebral Palsy with a Focus on Motor Function Improvement

The Comparison of Perinatal Outcomes in Early Delivery Versus Postdate Labor

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