Cerebral palsy and congenital malformations

Garne, Ester; Dolk, Helen; Krägeloh-Mann, I.; Ravn, Susanne Holst; Cans, Christine

doi:10.1016/j.ejpn.2007.07.001

Cited by 79 publications

(106 citation statements)

References 19 publications

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“…Garne et al 20 reported an increase in cardiac anomalies, facial clefts, and limb and skeletal anomalies in children with CP, using data from 11 CP registers for the period 1976 to 1996. Of note though, studies of non-CNS anomalies remain rare because of small sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Congenital non‐central nervous system malformations in cerebral palsy: a distinct subset?

Self

Dagenais

Shevell

2012

Develop Med Child Neuro

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AIM The aim of this article was to identify and contrast the subset of children with cerebral palsy (CP) and non-central nervous system (CNS) congenital malformations with children with CP but no coexisting non-CNS congenital malformations.METHOD A population-based regional comprehensive CP registry was used to identify children with CP who had non-CNS congenital malformations (n=34; 19 males, 15 females; 22 classified as Gross Motor Function Classification System [GMFCS] levels I-III, 12 as GMFCS level IV or V). Their clinical features were then compared with other children with CP without non-CNS congenital malformations (n=207; 115 males, 92 females; 138 classified as GMFCS levels I-III, 69 as GMFCS level IV or V).RESULTS Children with CP and non-CNS congenital malformations did not differ from those without in terms of neurological subtype distribution or functional severity, as measured by the GMFCS. Also, there was no association with previous maternal infections (i.e. toxoplasmosis, rubella, cytomegalovirus, herpes simplex virus 2 [TORCH]), maternal fever, use of illicit substances, asphyxia, neonatal encephalopathy, intraventricular haemorrhage, or septicaemia. The incidence of comorbidities such as convulsions, communication difficulties, gavage feeding, cortical blindness, and auditory impairment was not higher in this subgroup. INTERPRETATIONThe incidence of congenital non-CNS malformations among children with CP is appreciable. Children with these non-CNS malformations do not appear to differ from other children with CP regarding neurological subtype, functional severity, and comorbidities, or maternal or obstetrical factors. Thus, the specific presence of a non-CNS congenital malformation does not appear to assist the practitioner in the management or understanding of a child's CP.Cerebral palsy (CP) remains a significant cause of motor impairment in childhood, 1 affecting 0.15 to 0.25% of children (i.e. 1.5-2.5 ⁄ 1000 live births).2 CP is a neuromotor disability that originates from an anomaly and ⁄ or damage to the motor regions of the brain, leading to the early onset of observable motor dysfunction.3,4 CP can also be associated with non-motor impairments and disorders such as epilepsy, difficulties with feeding and communication, vision and hearing loss, cognitive disability, behavioural disturbances, and orthopaedic difficulties. 5,6 The aetiology of CP can be divided into two broad categories: (1) congenital anomalies ⁄ dysgenesis of the brain and (2) acquired brain injury. Congenital brain anomalies have been shown to be associated with low birthweight, low gestational age, and prenatal infections. Brain injury can be acquired following prenatal or birth ischaemia ⁄ asphyxia, central nervous system (CNS) trauma, haemorrhage, stroke, or infection. 5The objective of this study was to use a regional populationbased registry to compare risk factors, clinical presentation, and associated comorbidities of children with CP with an associated non-CNS congenital malformation with those without. The no...

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Section: Discussionmentioning

confidence: 99%

Congenital non‐central nervous system malformations in cerebral palsy: a distinct subset?

Self

Dagenais

Shevell

2012

Develop Med Child Neuro

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“…While this is not the first study of hand development in children with CP, [3][4][5] this is the first study of bimanual hand use using a standardized measure. The findings of the AHA differ from those of the Manual Ability Classification System in the same children, which is in line with the other developmental studies to date indicating that various aspects of hand development progress with different time courses and rates.…”

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confidence: 99%

“…It is, therefore, the more convincing that the same conclusions have been reached by Rankin et al 4 This work has taken further the investigation reported by Garne and European collaborators in 2008. 5 This simply compared the prevalence of congenital malformations reported in a number of high quality and standardized CP registers with that estimated using local population-based congenital malformation registers. Rankin et al 4 linked cases in three CP registers with those in local congenital malformation registers, thus obtaining more clinical information on the matched children.…”

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confidence: 99%

Congenital malformations and the cerebral palsies – déjà vu, but now what?

Alberman¹

2010

Develop Med Child Neuro

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“…On the other hand 15% of all cerebral palsy cases in this cohort were caused by brain malformations. Brain malformations were responsible for cerebral palsy only in 8.6% and 11.3% of patients according to Garne et al 80 and Self et al, 81 respectively. The differing data probably reflect some bias in the referral system.…”

mentioning

confidence: 99%

“…Brain malformations are a major cause of cerebral palsy, 80 and indeed, almost one third of our cases with brain malformations had cerebral palsy. On the other hand 15% of all cerebral palsy cases in this cohort were caused by brain malformations.…”

mentioning

confidence: 99%

Spectrum of neurodevelopmental disabilities in a cohort of children in Hungary

Gergev

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Cerebral palsy and congenital malformations

Cited by 79 publications

References 19 publications

Congenital non‐central nervous system malformations in cerebral palsy: a distinct subset?

Congenital non‐central nervous system malformations in cerebral palsy: a distinct subset?

Congenital malformations and the cerebral palsies – déjà vu, but now what?

Spectrum of neurodevelopmental disabilities in a cohort of children in Hungary

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