Cerebral palsy in children born after in vitro fertilization. Is the risk decreasing?

Källén, Anders; Finnström, Orvar; Lindam, Anna; Nilsson, Emma; Nygren, Karl-Gösta; Olausson, Petra M. Otterblad

doi:10.1016/j.ejpn.2010.03.007

Cited by 52 publications

(33 citation statements)

References 13 publications

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“…Neurological sequelae such as cerebral palsy (CP) are more frequently seen in ART-conceived children compared with NC children (Strömberg et al, 2002;Hvidtjørn et al, 2006;2010;Klemetti et al, 2006;Romundstad et al, 2008;Källén A.J. et al, 2010;Zhu et al, 2010;Saunders et al, 2011).…”

Section: Neurological and Neurodevelopmental Outcomesmentioning

confidence: 99%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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Children conceived via assisted reproductive technologies (ART) are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks compared to naturally conceived (NC) children. In recent years there has been a lot of work in this field. This review will summarize what is known about the health of ART-conceived children, encompassing neonatal outcomes, birth defects, growth and gonadal developments, physical health, neurological and neurodevelopmental outcomes, psychosocial developments, risk for cancer, and epigenetic abnormalities. Most of the children conceived after ART are normal. However, there is increasing evidence that ART-conceived children are at higher risk of poor perinatal outcome, birth defects, and epigenetic disorders, and the mechanism(s) leading to these changes have not been elucidated. Continuous follow-up of children after ART is of great importance as they progress through adolescence into adulthood, and new ART techniques are constantly being introduced.

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Section: Neurological and Neurodevelopmental Outcomesmentioning

confidence: 99%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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“…Referring to this finding, Lidegaard et al (18) suggested that socalled vanishing twins might be the only explanation of the increased risk of CP in IVF singletons. Additional confirmation of this conclusion lies in the fact that no increased risk of CP was assessed in IVF twins as compared with age-matched non-IVF twins (6,21,32,34).…”

Section: Discussionmentioning

confidence: 90%

“…The authors revealed between 1.6-and 3.7-fold increased risks of CP in IVF children when compared to naturally conceived children (6,10,18,21,25,33,34). The recent meta-analysis (41) of summarized data on 19,462 IVF children showed an increased risk of CP with estimated crude OR of 2.18 (95% CI: 1.71-2.77).…”

Section: Discussionmentioning

confidence: 99%

“…According to the regression analysis, the risk of CP in IVF children is largely attributed to a high proportion of multiple pregnancies, low birth weight, and prematurity in this population (6,14,21,25,41). The selected studies showed inconsistent findings as some found an association between CP and IVF singletons (18,21) and others did not (6,14,25,27,34). As for twin pregnancies after IVF, some studies found no difference in the risk of CP between IVF twins and naturally conceived twins (6, 21 ,32, 34).…”

Section: Discussionmentioning

confidence: 99%

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Assessing the Risk of Cerebral Palsy in Children Born after Assisted Conception – The Role of Multiple Pregnancy and Preterm Delivery / Procena rizika od cerebralne paralize kod dece začete vantelesnim oplođenjem – uloga višestruke trudnoće i prevremenog rođenja

Milićević¹,

Potić²

2015

Acta Facultatis Medicae Naissensis

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For more than three decades, assisted reproductive techniques (ART) have been used as effective treatments to overcome infertility. Since then, numerous studies have been focused on different aspects of long-term health and development of children born after assisted conception. The aim of this paper is to summarize new data on multiple pregnancy and preterm delivery as one of the risk factors which might increase the risk of developing cerebral palsy (CP) in children born after assisted conception.A comprehensive search of eight databases retrieved 108 papers, 10 of which met inclusion criteria and were relevant for this review.Despite the dissimilarities in methodological and analytic approaches in the selected studies, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are generally considered safe, still there is an ongoing discussion whether multiple pregnancy and preterm delivery increase or do not increase the risk of CP in children born after assisted conception.All information about possible adverse maternal and/or infant outcomes should be made available to the couples seeking ART treatment.

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“…Einen interessanten Beitrag zu dieser Diskussion leistete vor kurzem eine Auswertung aus Schweden über 25 Jahre hinweg: Die Daten zeigten insgesamt eine Verbesserung des neonatalen Outcome, sehr wahrscheinlich Folge der geringeren Mehrlingsrate, aber auch eine Verbesserung explizit für Einlinge [18]. Die Autoren diskutieren, dass dies durch eine groß-zügigere Indikationsstellung und damit durch die Durchführung von IVF auch bei weniger ausgeprägten Pathologien erklärt werden kann.…”

Section: Fehlbildungen Und Imprinting-fehlerunclassified

Kinder nach assistierter Reproduktion

Ludwig

2011

Gynäkologe

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Kinder nach assistierter Reproduktion Follow-upLeitthema Ungefähr 3% der Kinder in Deutschland werden mit assistierter Reproduktion (ART) geboren. Im Folgenden soll die Gesundheit der nach Kinderwunschbehandlung geborenen Kinder anhand der vorhandenen wissenschaftlichen Daten beleuchtet werden. Herausgearbeitet werden die Punkte, die in eine Aufklärung von Kinderwunschpaaren unbedingt eingehen sollten. Risiken, die explizit durch den Mehrlingsstatus bedingt sind, werden in diesem Artikel nicht behandelt.

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Cerebral palsy in children born after in vitro fertilization. Is the risk decreasing?

Cited by 52 publications

References 13 publications

Long-term follow-up of children conceived through assisted reproductive technology

Long-term follow-up of children conceived through assisted reproductive technology

Assessing the Risk of Cerebral Palsy in Children Born after Assisted Conception – The Role of Multiple Pregnancy and Preterm Delivery / Procena rizika od cerebralne paralize kod dece začete vantelesnim oplođenjem – uloga višestruke trudnoće i prevremenog rođenja

Kinder nach assistierter Reproduktion

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