Cerebral perfusion assessment by bolus tracking using hyperpolarized <sup>13</sup>C

Johansson, Edvin; Månsson, Sven; Wirestam, Ronnie; Svensson, Jonas; Petersson, Johan; Golman, Klaes; Ståhlberg, Freddy

doi:10.1002/mrm.20013

Cited by 97 publications

(93 citation statements)

References 39 publications

(66 reference statements)

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“…The hyperpolarization technique using 13 C, incorporated into small molecules (19,20), has produced polarization levels several orders of magnitude higher than thermal equilibrium values. The use of hyperpolarized 13 C substances for MR angiography (21,22), passive catheter tracking in interventional MRI (23), and perfusion (24,25) has been demonstrated. The dynamic nuclear polarization (DNP) method (20) may be used to enhance the signal of the 13 C-nuclei in endogenous substances such as amino acids, urea, and pyruvate (26,27), making it possible to perform in vivo visualization of the injected substances and their metabolites.…”

mentioning

confidence: 99%

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

Golman

Petersson

Magnusson

et al. 2008

Magnetic Resonance in Med

207

238

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Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO 2 in equilibrium with HCO 3 ؊ . The aim of this study was to evaluate the feasibility of using 13 C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart during an ischemic episode. The left circumflex artery of pigs (4 months, male, 29 -34 kg) was occluded for 15 or 45 min followed by 2 hr of reperfusion. Pigs were examined by 13 C chemical shift imaging following intravenous injection of 1-13 C pyruvate. 13 C chemical shift MR imaging was used in order to visualize the local concentrations of the metabolites. After a 15-min occlusion (no infarct) the bicarbonate signal level in the affected area was reduced (25-44%) compared with the normal myocardium. Alanine signal level was normal. After a 45-min occlusion (infarction) the bicarbonate signal was almost absent (0.2-11%) and the alanine signal was reduced (27-51%). Due to image-folding artifacts the data obtained for lactate were inconclusive. These studies demonstrate that cardiac metabolic imaging with hyperpolarized 1-13 C-pyruvate is feasible. The changes in concentrations of the metabolites within a minute after injection can be detected and metabolic maps constructed. Magn Reson Med 59:1005-1013, 2008.

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mentioning

confidence: 99%

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

Golman

Petersson

Magnusson

et al. 2008

Magnetic Resonance in Med

207

238

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“…Therefore, the signal in a 13 C image obtained after injection of a hyperpolarized substance is proportional to the concentration of the agent in question, and the image acts as a qualitative map of perfusion [11][12][13][14]. Likewise, the conversion of hyperpolarized 13 C-labelled compounds such as pyruvate can be followed with Magnetic Resonance Spectroscopic Imaging (MRSI) [15][16][17], and the metabolic activity monitored [18].…”

Section: Mramentioning

confidence: 99%

Hyperpolarized ¹³C MR Angiography

Lipsø¹,

Magnusson²,

Ardenkjær‐Larsen

2015

CPD

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Magnetic resonance angiography (MRA) is a non-invasive technology that can be used for diagnosis and monitoring of cardiovascular disease; the number one cause of mortality worldwide.Hyperpolarized imaging agents provide signal enhancement of more than 10,000 times, which implies large reduction in acquisition time and improved spatial resolution. We review the role of hyperpolarized 13 C agents for MR angiography and present the literature in the field. Furthermore, we present a study of the benefit of intraarterial injection over intravenous injection of hyperpolarized agent for cerebral angiography in the rat, and compare the performance of two standard angiographic pulse sequences, the gradient echo (GRE) sequence and the balanced steady-state free precession (bSSFP).2D coronal cerebral angiographies using intra-arterial injections were acquired with a GRE sequence with in-plane resolution of 0.27 mm and matrix size 256x128, and 2D coronal cerebral angiographies were acquired with a bSSFP sequence with in-plane resolution of 0.55 mm and matrix size 128x64.The bSSFP sequence provides higher SNR in phantoms than the GRE sequence. Similarly, intravenous injections are imaged with higher SNR with the bSSFP sequence, where the signal destruction of the GRE sequence is avoided. However, for intra-arterial injections, the bSSFP sequence results in strong artefacts, and the GRE sequence is preferred.Hyperpolarized MRA presents many challenges and cannot currently compete with conventional contrast enhanced MRA. Further research may change this since hyperpolarization is still an immature methodology.3

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“…In addition, depolarization as a result of repetitive radiofrequency pulsing has to be considered, which further destroys longitudinal magnetization. Johansson et al 59 showed that depolarization can be approximated by a monoexponential function and successfully applied this concept for cerebral perfusion quantification. So far, these contrast media are only applied in animal experiments, 59 but preliminary results are encouraging.…”

Section: Hyperpolarized C-13 CMmentioning

confidence: 99%

“…Johansson et al 59 showed that depolarization can be approximated by a monoexponential function and successfully applied this concept for cerebral perfusion quantification. So far, these contrast media are only applied in animal experiments, 59 but preliminary results are encouraging. An example of a cardiac perfusion study using an intravascular C-13 compound is given in Figure 5.…”

Section: Hyperpolarized C-13 CMmentioning

confidence: 99%

Myocardial perfusion imaging by cardiac magnetic resonance

Schwitter

2006

Journal of Nuclear Cardiology

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Cerebral perfusion assessment by bolus tracking using hyperpolarized ¹³C

Cited by 97 publications

References 39 publications

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

Hyperpolarized ¹³C MR Angiography

Myocardial perfusion imaging by cardiac magnetic resonance

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Cerebral perfusion assessment by bolus tracking using hyperpolarized 13C

Cited by 97 publications

References 39 publications

Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI

Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI

Hyperpolarized 13C MR Angiography

Myocardial perfusion imaging by cardiac magnetic resonance

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Cerebral perfusion assessment by bolus tracking using hyperpolarized ¹³C

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

Cardiac metabolism measured noninvasively by hyperpolarized ¹³C MRI

Hyperpolarized ¹³C MR Angiography