Cerebral Phaeohyphomycosis due to Cladosporium spp. in a Lion (Panthera leo)

Rocha, P.R.D.; Dutra, Valéria; Maruyama, Fernanda Harumi; García, Sandra; Duarte, Roberta Picciuto; Azevedo, E.; Nazakato, L.; Machado, G. F.

doi:10.1016/j.jcpa.2016.11.184

Cited by 2 publications

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“…2,8 Although we found no other reports of disseminated phaeohyphomycosis or mycetoma in a non-domestic felid, there is a report of cerebral phaeohyphomycosis in a female lion. 14 There is also a report of eumycetoma in a domestic Persian cat, secondary to a Microsporum canis infection. 9 M. canis is classically known for causing dermatophytosis.…”

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Eumycetoma and disseminated phaeohyphomycosis in a Sumatran tiger

et al. 2021

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A 16-y-old female Sumatran tiger ( Panthera tigris sumatrae) was evaluated for hyporexia. Examination revealed chronic kidney disease and a large subcutaneous axillary mass with draining tracts that contained numerous small black grains. Histologic examination revealed the presence of intralesional fungal hyphae. Persistent hyporexia and pyogranulomatous disease, as well as progressive cachexia and azotemia occurred despite treatment, and euthanasia was performed. Disseminated phaeohyphomycosis was diagnosed on postmortem examination, additionally affecting various lymph nodes, the nasal cavity, mesenteric adipose tissue, abdominal aorta, pericardium, and kidney. Fungal culture from a deep-tissue sample isolated a pure growth of Curvularia sp., a dematiaceous opportunistic fungus able to cause eumycetomas and/or phaeohyphomycosis. Phaeohyphomycosis is a rare but emerging condition, not previously reported as disseminated disease in an exotic carnivore, to our knowledge. Aggressive systemic antifungal treatment was unsuccessful, likely complicated by diagnostic challenges and concurrent renal disease. The presence of a swelling with abundant grains exiting draining tracts should direct clinicians to the diagnosis of a mycetoma, warranting early and aggressive treatment.

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Eumycetoma and disseminated phaeohyphomycosis in a Sumatran tiger

et al. 2021

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“…In the literature, there are numerous case reports of cutaneous and visceral infections caused by dematiaceous fungi in cats, while in wild captive-kept felids only a few have been reported [5,6,[10][11][12][13].…”

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“…Specifically, Cladophialophora bantiana was isolated from an abscess in the spinal cord of a snow leopard, [11] Cladosporium spp. from a cerebral lesion in a lion, [12] and Curvalaria spp. in disseminated cutaneous and visceral lesions in a Sumatran tiger [13].…”

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Eumycetoma Caused by Madurella pseudomycetomatis in a Captive Tiger (Panthera tigris)

Orlandi¹,

Giglia

Danesi

et al. 2022

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A captive-kept adult male tiger presented with a large cutaneous and subcutaneous mass on the thigh with a fistula. During sedation, multiple nodules were detected and samples for a histopathological exam were collected. Histologically, granulomatous panniculitis and dermatitis were seen around dense aggregates of pigmented fungal hyphae, and a diagnosis of phaeohyphomycosis was made; considering the clinical features, it was classified as a eumycotic mycetoma. This is a rarely reported subcutaneous fungal infection in humans and animals, caused by dematiaceous fungi. Clinically, it is characterized by tumefaction, fistulous sinus tracts, and the formation of macroscopically visible grains. In the literature, only a few infections in wild felids have been reported. In this case, Fontana–Masson staining better showed pigmentation and panfungal PCR and sequencing identified Madurella pseudomyectomatis (OP623507) as the causative agent. Systemic therapy with oral administration of itraconazole was planned, but the patient died during the first period of treatment. The animal was not submitted for post-mortem examination. Visceral dissemination of the agent cannot be excluded. To the authors’ knowledge, this is the first report of eumycotic mycetoma by Madurella pseudomycetomatis in a captive tiger.

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Cerebral Phaeohyphomycosis due to Cladosporium spp. in a Lion (Panthera leo)

Cited by 2 publications

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Eumycetoma and disseminated phaeohyphomycosis in a Sumatran tiger

Eumycetoma and disseminated phaeohyphomycosis in a Sumatran tiger

Eumycetoma Caused by Madurella pseudomycetomatis in a Captive Tiger (Panthera tigris)

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