Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation

Xia, Yunfei; Wang, Zhengping; Zhou, Yachun; Yan, Tao; Li, Shitong

doi:10.1016/s1499-3872(12)60137-4

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Nicorandil, a vasodilator with nitrate properties, has been reported to have cerebral protective effects in neuronal injury models [62]. Similar findings were reported by Xia et al [41] in a trial comparing nicorandil with physiological saline in 40 patients undergoing liver transplantation: Mini-Mental-State examination scores were significantly higher in the nicorandil group.…”

Section: Primary Graft Failure Cognitive Dysfunction and Other Complsupporting

confidence: 68%

“…Twenty studies reporting on anesthetic strategies aiming at reducing postoperative morbidity and mortality were eventually included (Table 1) [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. We retrieved 14 studies reporting on postoperative complications in patients undergoing liver transplantation [22][23][24]28,29,[31][32][33][35][36][37][39][40][41], five studies conducted in kidney recipients [26,27,30,34,38] and one reporting on lung recipients [25].…”

Section: Synthesis Of Resultsmentioning

confidence: 99%

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Organ protection in allograft recipients

Hovaguimian

Schläpfer

Beck‐Schimmer

2014

Current Opinion in Organ Transplantation

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Section: Primary Graft Failure Cognitive Dysfunction and Other Complsupporting

confidence: 68%

Section: Synthesis Of Resultsmentioning

confidence: 99%

Organ protection in allograft recipients

Hovaguimian

Schläpfer

Beck‐Schimmer

2014

Current Opinion in Organ Transplantation

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“…Studies assessing the protective effects of nicorandil in the brain have demonstrated that its protective function is mediated by the activation of mitoKATPs ( 19 , 20 ). It has also been determined that premedication with nicorandil induces a cerebroprotective effect in patients receiving liver transplants ( 21 ). However, the protective effect of nicorandil in brain tissue following CPR remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of nicorandil against cerebral injury in a swine cardiac arrest model

et al. 2018

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The present study investigated the effects of nicorandil on cerebral injury following cardiopulmonary resuscitation (CPR) in a swine model of cardiac arrest. CPR was performed on swine following 4 min induced ventricular fibrillation. Surviving animals were randomly divided into 3 groups: A nicorandil group (n=8), a control group (n=8) and a sham group (n=4). The sham group underwent the same surgical procedure to imitate cardiac arrest, but ventricular fibrillation was not induced. When the earliest observable return of spontaneous circulation (ROSC) was detected, the nicorandil and control groups received injections of nicorandil and saline, respectively. Swine serum was collected at baseline and 5 min, 0.5, 3 and 6 h following ROSC. Serum levels of neuron-specific enolase (NSE), S100β, tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) were measured using ELISA. Animals were euthanized and brain tissue samples were collected and assessed using light and electron microscopy 6 h following ROSC. The expression of aquaporin-4 (AQP-4) in the brain tissue was measured using western blotting. Malondialdehyde (MDA) and glutathione (GSH) levels in the brain tissue were determined using thiobarbituric acid and thiobenzoic acid colorimetric methods, respectively. Serum NSE and S100β were significantly higher in the nicorandil and control groups following CPR, compared with baseline (P<0.05). Additionally, NSE and S100β levels were significantly lower in the nicorandil group compared with the control (P<0.05). Pathological examinations and electron microscopy indicated that nicorandil reduced brain tissue damage. TNF-α and IL-6 levels were significantly decreased in the nicorandil group compared with the control group (P<0.05). Furthermore, AQP-4 expression in brain tissue 6 h following ROSC was significantly lower in the nicorandil group compared with the control group (P<0.05). MDA and GSH levels in swine brain tissue decreased and increased, respectively, in the nicorandil group compared with the control group (P<0.05). The results of the present study demonstrate that nicorandil exerts a protective effect against brain injury following cardiac arrest by reducing oxidative damage, inflammatory responses and brain edema post-ROSC.

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The spectroscopic (FT-IR, FT-Raman and NMR), NCA, Fukui function analysis first order hyperpolarizability, TGA of 6-chloro-3,4dihydro-2H-1,2,4-benzothiazine-7-sulphonamide1,1-dioxide by ab initio HF and Density Functional method

Porchelvi¹,

Muthu

2014

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation

Cited by 4 publications

References 20 publications

Organ protection in allograft recipients

Organ protection in allograft recipients

Protective effects of nicorandil against cerebral injury in a swine cardiac arrest model

The spectroscopic (FT-IR, FT-Raman and NMR), NCA, Fukui function analysis first order hyperpolarizability, TGA of 6-chloro-3,4dihydro-2H-1,2,4-benzothiazine-7-sulphonamide1,1-dioxide by ab initio HF and Density Functional method

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