Cerebral serotonin in viral encephalitis

Lima, Lucimey; Drujan, B. D.; Walder, R.

doi:10.1007/978-3-7091-9050-0_14

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Arboviral encephalitis like Japanese encephalitis are equally devastating with a mortality rate of 25-40% [7] and most survivors develop long term disabilities like seizure, mental retardation, motor deficit and behavioral abnormalities [8]. The precise pathophysiological basis of such long-term cognitive sequelae remains largely unknown and research into the affected central neurotransmitter systems are at preliminary laboratory research stage [9][10][11]. In absence of clearly delineated pathophysiological substrates of postencephalitic cognitive sequelae, no pharmacotherapeutic models for its management currently exist and so patients are treated symptomatically with almost no hope of recovery [7].…”

Section: Introductionmentioning

confidence: 99%

A novel therapeutic intervention for postencephalitic mental retardation

2015

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Viral encephalitis is often followed by cognitive sequelae including intellectual decline whose pathophysiology remains obscure till date. Based on recent laboratory studies implicating the cholinergic system in viral encephalitis, the authors postulate the hypothesis that cholinergic deficit might account for some of the cognitive sequelae in at least some types of viral encephalitis, which might be benefited by central acetyl cholinesterase inhibitors. The case of an adolescent with postencephalitic intellectual decline responding robustly to donepezil is presented.

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Section: Introductionmentioning

confidence: 99%