Cerebral Small-Vessel Diseases: A Look Back from 1991 to Today

Grosset, Lina; Jouvent, Éric

doi:10.1159/000522213

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…[202][203][204][205][206] Age-related volume deficits in thalamus and cerebellum occur at a slower rate than declines in cortical gray matter. [207][208][209][210][211] Gross white matter volume remains relatively stable across adulthood; 201,[212][213][214] however, appropriate imaging modalities (e.g., fluid-attenuated inversion recovery, diffusion tensor imaging) demonstrate more hyperintense inclusions (i.e., white matter hyperintensities [WMH]), [215][216][217][218] and microstructural compromise in older relative to younger individuals. [219][220][221][222] Cross-sectional neuroimaging reports support AUD-related volume shrinkage in specific brain structures, including frontal, temporal, and parietal cortices; diencephalon; brain stem; and cerebellum.…”

Section: Postmortem Neuropathologymentioning

confidence: 99%

Alcohol Use Disorder and Dementia: A Review

Zahr

2024

ARCR

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PURPOSE By 2040, 21.6% of Americans will be over age 65, and the population of those older than age 85 is estimated to reach 14.4 million. Although not causative, older age is a risk factor for dementia: every 5 years beyond age 65, the risk doubles; approximately one-third of those older than age 85 are diagnosed with dementia. As current alcohol consumption among older adults is significantly higher compared to previous generations, a pressing question is whether drinking alcohol increases the risk for Alzheimer’s disease or other forms of dementia. SEARCH METHODS Databases explored included PubMed, Web of Science, and ScienceDirect. To accomplish this narrative review on the effects of alcohol consumption on dementia risk, the literature covered included clinical diagnoses, epidemiology, neuropsychology, postmortem pathology, neuroimaging and other biomarkers, and translational studies. Searches conducted between January 12 and August 1, 2023, included the following terms and combinations: “aging,” “alcoholism,” “alcohol use disorder (AUD),” “brain,” “CNS,” “dementia,” “Wernicke,” “Korsakoff,” “Alzheimer,” “vascular,” “frontotemporal,” “Lewy body,” “clinical,” “diagnosis,” “epidemiology,” “pathology,” “autopsy,” “postmortem,” “histology,” “cognitive,” “motor,” “neuropsychological,” “magnetic resonance,” “imaging,” “PET,” “ligand,” “degeneration,” “atrophy,” “translational,” “rodent,” “rat,” “mouse,” “model,” “amyloid,” “neurofibrillary tangles,” “α-synuclein,” or “presenilin.” When relevant, “species” (i.e., “humans” or “other animals”) was selected as an additional filter. Review articles were avoided when possible. SEARCH RESULTS The two terms “alcoholism” and “aging” retrieved about 1,350 papers; adding phrases—for example, “postmortem” or “magnetic resonance”—limited the number to fewer than 100 papers. Using the traditional term, “alcoholism” with “dementia” resulted in 876 citations, but using the currently accepted term “alcohol use disorder (AUD)” with “dementia” produced only 87 papers. Similarly, whereas the terms “Alzheimer’s” and “alcoholism” yielded 318 results, “Alzheimer’s” and “alcohol use disorder (AUD)” returned only 40 citations. As pertinent postmortem pathology papers were published in the 1950s and recent animal models of Alzheimer’s disease were created in the early 2000s, articles referenced span the years 1957 to 2024. In total, more than 5,000 articles were considered; about 400 are herein referenced. DISCUSSION AND CONCLUSIONS Chronic alcohol misuse accelerates brain aging and contributes to cognitive impairments, including those in the mnemonic domain. The consensus among studies from multiple disciplines, however, is that alcohol misuse can increase the risk for dementia, but not necessarily Alzheimer’s disease. Key issues to consider include the reversibility of brain damage following abstinence from chronic alcohol misuse compared to the degenerative and progressive course of ...

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Section: Postmortem Neuropathologymentioning

confidence: 99%

Alcohol Use Disorder and Dementia: A Review

Zahr

2024

ARCR

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“…Cerebral stroke is a primary cause of disability and death worldwide and occurs at main branches of the cerebral arteries, basilar arteries, their associated small vessels and corresponding veins (1). Its differential diagnosis can be difficulty, particularly when it involves small vessel and complications with other CVDs (2,3). Moreover, there are many brain diseases not primarily involving cerebral vessels but presenting physical and mental symptoms similar to that of the stroke, such as hyponatremia, multiple sclerosis and brain tumors.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, many excellent reviews of neuroimaging have been published. They focus on either general imaging techniques of ischemic CVDs (5,6) or a specific MRI sequence like vessel wall MRI (2,3) and multiparametric quantitative MRI (7). However, a comprehensive overview of MRI sequences and their administration in differentiation of cerebral stroke from other neurological diseases remains to be presented.…”

Section: Introductionmentioning

confidence: 99%

Advances in differential diagnosis of cerebrovascular diseases in magnetic resonance imaging: a narrative review

Li¹,

Su²,

Yuan³

et al. 2023

Quant Imaging Med Surg

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Background and Objective: Cerebrovascular diseases (CVDs), particularly cerebral stroke, remain a primary cause of disability and death worldwide. Accurate diagnosis of CVDs is essential to guide therapeutic decisions and foresee the prognosis. Different CVDs have different pathological processes while they have many signs in common with some other brain diseases. Thus, differential diagnoses of strokes from other primary and secondary CVDs are especially important and challenging.Methods: This review is composed mainly based on searching PubMed articles

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“…В качестве одного из патогенетических механизмов КН для неврологических заболеваний выступает корковоподкорковое разобщение, возникающее вследствие очагового поражения (сосудистого / травматического / демиелинизирующего) подкоркового белого вещества больших полушарий, в более редких случаях -непосредственное поражение коры [29], определяемое при помощи магнитно-резонансной томографии (МРТ) головного мозга [30]. Важно отметить, что поражение головного мозга, за исключением вовлечения перивентрикулярного пространства и нижней части мозолистого тела, не является характерным для ЗСОНМ [31].…”

unclassified

“…В последние годы активно обсуждаются и другие патогенетические механизмы, приводящие к КН, в частности О Б З О Р Ы Неврология, нейропсихиатрия, психосоматика. 2024;16(3):117-122 астроцитопатия с нарушением метаболической активности нейронов [29], что может иметь отношение к патогенезу КН при ЗСОНМ. При сопоставлении наличия КН с исследованиями биопсийного материала при ЗСОНМ (шесть случаев, 64 образца) было установлено усиление менингеального воспаления, включая CD45-RO-позитивные Т-клетки, CD20 + В-клетки и основные гистосовместимые клетки класса II, в отличие от контроля [24].…”

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Cognitive impairment in neuromyelitis optica spectrum disorders

Vekhina,

Kasatkin,

Korchevnyi

et al. 2024

RJTAO

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Neuromyelitis optica spectrum disorders (NMOSD) are a group of immune-mediated inflammatory lesions of the central nervous system that primarily cause dysfunction and death of astrocytes, leading to secondary disruption of myelination. The optic nerve, the spinal cord, the brain stem (periventricular and periaqueductal space) and the diencephalon are most frequently affected sites. According to a meta-analysis of 25 studies, the prevalence of cognitive impairment (CI) in 761 patients with NMOSD aged 34 to 53 years was between 3 and 75%, after adjustment this figure was 34%. The most frequently observed CI in NMOSD are decreased attention and working memory function, reduced information processing speed and impaired verbal memory and fluency. A significant influence on the severity of CI in NMOSD have the patient's age, the duration of the disease, the level of education, the degree of disability and the severity of upper and lower limb dysfunction. The data collected suggest that neurodegenerative disorders, including CI, are characteristic of this pathology. The pathogenesis of CI in NMOSD is very complex and involves both mechanisms of direct damage to structures that perform cognitive functions (hippocampus, prefontal cortex) and immunological aspects (microglia, complement, interleukin 6), which requires further investigation.

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Cerebral Small-Vessel Diseases: A Look Back from 1991 to Today

Cited by 5 publications

References 39 publications

Alcohol Use Disorder and Dementia: A Review

Alcohol Use Disorder and Dementia: A Review

Advances in differential diagnosis of cerebrovascular diseases in magnetic resonance imaging: a narrative review

Cognitive impairment in neuromyelitis optica spectrum disorders

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