Cerebral structure in borderline personality disorder

Lucas, Peter; Gardner, David L.; Cowdry, Rex W.; Pickar, David

doi:10.1016/0165-1781(89)90126-1

Cited by 25 publications

(6 citation statements)

References 21 publications

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“…Similar to research on brain alterations in schizophrenic patients, whole brain volumes and ventricle sizes were investigated. In contrast to findings in schizophrenia, studies in BPD did not show ventricular enlargement (Schulz et al, 1983;Snyder et al, 1983), or changes in ventricle-brain ratio (Lucas et al, 1989) in patients with BPD. With the advent of Magnetic Resonance Imaging, Lyoo reported a marginally significant reduction of overall frontal lobe volumes in BPD (Lyoo, 1998), although this finding has been criticized for technical reasons such as low spatial resolution and lack of correction for head tilt.…”

Section: Volumetrics and Spectroscopymentioning

confidence: 78%

Neuroimaging in borderline personality disorder

Schmahl¹,

Bremner²

2006

Journal of Psychiatric Research

171

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Neuroimaging has become one of the most important methods in the investigation of the neurobiological underpinnings of borderline personality disorder. Structural and functional imaging studies have revealed dysfunction in different brain regions which seem to contribute to borderline symptomatology. This review presents relevant studies using different methodologies: volumetry of limbic and prefrontal regions, investigations of brain metabolism under resting conditions, studies of serotonergic neurotransmission, and challenge studies using emotional, stressful, and sensory stimuli. Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology.

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Section: Volumetrics and Spectroscopymentioning

confidence: 78%

Neuroimaging in borderline personality disorder

Schmahl¹,

Bremner²

2006

Journal of Psychiatric Research

171

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“…Two of these studies found that the CT results of borderline patients were essentially normal (Schulz et al, 1983;Snyder, Pitts, & Gustin, 1983). Two others found that 13%-39% of borderline patients had abnormal CT findings rates that did not distinguish them from healthy normal or axis II controls (Lucas, Gardner, Cowdry, & Pickar, 1989;Zanarini, Kimble, & Williams, 1994).…”

Section: Temperamental Concernsmentioning

confidence: 95%

Pathways to the Development of Borderline Personality Disorder

Zanarini¹,

Frankenburg²

1997

Journal of Personality Disorders

208

100

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The available empirical evidence concerning the etiology of borderline personality disorder is reviewed. A tripartite model of the development of BPD is then presented. This model has three elements: a traumatic childhood (broadly defined), a vulnerable (hyperbolic) temperament, and a triggering event or series of events. The authors conclude that each borderline patient has a unique pathway to the development of BPD that is a painful variation on an unfortunate but familiar theme.

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“…Except for the study by Lyoo, Han, and Cho (1998), no severe structural brain abnormalities in the frontal lobe have yet been found to be associated with BPD (Lucas, Gardner, Cowdry, & Pickar, 1989;Snyder, Pitts, & Quinton, 1983). Even though Lyoo et al (1998) found a significantly smaller frontal lobe in a morphological brain magnetic resonance imaging (MRI) analysis of 25 BPD subjects compared to healthy age-and gender-matched controls, their results have some limitations regarding the inclusion and exclusion criteria for BPD subjects and methodological aspects of their MRI analysis, which may compromise the general significance of their findings.…”

mentioning

confidence: 96%

Frontal Lobe Dysfunctions in Borderline Personality Disorder? Neuropsychological Findings

Kunert¹,

Druecke²,

Saß³

et al. 2003

Journal of Personality Disorders

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This study aims to determine whether specific neuropsychological performance impairments in borderline patients can be objectified and whether these findings indicate frontal dysfunctions. Twenty-three patients with borderline personality disorder and 23 normal controls were examined using a neuropsychological test battery to assess intelligence, attentiveness, proneness to interference, learning and memory, as well as planning and problem solving. All subjects filled out standardized questionnaires to assess aggressiveness and impulsiveness in the context of these cognitive performance areas. The neuropsychological test results of the borderline patients were comparable to those of the controls. Although there were no indications of frontal dysfunction of cognitive information processing, inverse correlations were found between the severity of borderline-related personality traits regarding impulsiveness and various areas of cognitive performance. Borderline personality patients show no indications of frontal cognitive dysfunction. Further research is needed to clarify the relationship between impulsiveness and cognitive information processing in borderline personality disorder, including a dimensional approach to personality and personality disorder.

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Cerebral structure in borderline personality disorder

Cited by 25 publications

References 21 publications

Neuroimaging in borderline personality disorder

Neuroimaging in borderline personality disorder

Pathways to the Development of Borderline Personality Disorder

Frontal Lobe Dysfunctions in Borderline Personality Disorder? Neuropsychological Findings

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