Cerebral structure on MRI, Part I: Localization of age-related changes

Jernigan, Terry L.; Archibald, Sarah; Berhow, Melissa T.; Sowell, Elizabeth R.; Foster, David S.; Hesselink, John R.

doi:10.1016/0006-3223(91)90210-d

Cited by 358 publications

(210 citation statements)

References 21 publications

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“…Because of the marked age-related reduction in total brain volume, it was examined whether the regional volume decreases were disproportional compared to the global reductions. Other studies have reported that frontal and temporal association areas are particularly affected by advancing age [8,20,31]. In this study, none of the regional volume reductions were greater than expected given the decrease in total brain volume.…”

Section: Normal Brain Agingcontrasting

confidence: 58%

“…For instance, a region that is frequently reported to show disproportional volume losses during the nonpathological aging process is the prefrontal cortex [8,20,31]. Several authors have even suggested that age-related cognitive deterioration is principally the consequence of alterations in prefrontal structure and function (e.g.…”

Section: Relation Between Brain Volumes and Cognitive Performancementioning

confidence: 99%

“…Widening of the ventricular and sulcal liquor spaces is clearly evident in elderly persons [2,6,8,21,22,27], and studies that directly measured brain volume have found age-related reductions in total and gray (but not white) matter volumes [8,21,30,31]. This atrophy seems to occur particularly in the frontal and temporal lobes [8,31], and also in subcortical regions [20].…”

Section: Introductionmentioning

confidence: 99%

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The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

Tisserand

Visser

Boxtel

et al. 2000

Neurobiology of Aging

118

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The present study investigated the range of age-related changes in brain morphology and the relation with performance on memory and other cognitive tests in a healthy population. A group of 61 subjects (21 to 81 years old, mean ϭ 55.7), free from cognitive and medical deficits, underwent MRI scanning and neuropsychological assessment encompassing memory and other cognitive tests. Volumetry of the hippocampus, parahippocampal gyrus, mamillary bodies, third ventricle, and total brain matter was performed. The results indicate that in healthy individuals increases in ventricular volume and volume decreases in total brain matter, hippocampus and parahippocampal gyrus, but not mamillary bodies, are clearly apparent with increasing age. However, no relation could be established between the brain volumes and test performance when controlling for the effects of age. To conclude, variations in total and limbic brain volumes do not seem predictive for cognitive performance independent of age.

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Section: Normal Brain Agingcontrasting

confidence: 58%

Section: Relation Between Brain Volumes and Cognitive Performancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

Tisserand

Visser

Boxtel

et al. 2000

Neurobiology of Aging

118

View full text Add to dashboard Cite

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“…Imaging studies of normal development have demonstrated that after early adolescence, when maximum total gray matter volume is reached (Giedd et al 1999a), cortical gray matter volume continues to decrease throughout the life-span (Jernigan et al 1991;Lim et al 1992;Pfefferbaum et al 1994;Sullivan et al 1995;Raz et al 1997;Passe et al 1997;Gur et al 1999;Bartzokis et al 2001). Post-mortem data suggests that this gray matter volume decrease is primarily a result of large neuron shrinkage and pruning of processes with minimal if any neuronal cell loss before the age of 55 (Terry et al 1987;Haug 1987;Pakkenberg and Gundersen 1997;Peters et al 1998).…”

Section: Extending the Temporal Domain Of Brain Developmentmentioning

confidence: 99%

Schizophrenia Breakdown in the Well-regulated Lifelong Process of Brain Development and Maturation

Bartzokis

2002

Neuropsychopharmacology

173

133

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“…The image-analytic approach is similar to that used in our previous anatomical studies (Jernigan et al, 1990(Jernigan et al, , 1991a(Jernigan et al, , 1991bJernigan & Ostergaard, 1993), but represents a significant elaboration of these methods as described in Jernigan et al (2001aJernigan et al ( , 2001b. Trained anatomists who are blind to subject diagnosis, age, gender or any other identifying information subject each image dataset to the following image analysis procedures: (1) interactive isolation of intracranial regions from surrounding extracranial tissue, (2) three-dimensional digital filtering of the matrix of pixel values representing brain voxels to reduce inhomogeneity artifact, (3) reslicing of the volume to a standard orientation, (4) tissue segmentation using semi-automated algorithms, and (5) neuroanatomical region-of-interest analysis.…”

Section: Image Analysismentioning

confidence: 99%

Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: A structural MRI study

Murphy

Jernigan

Fennema-Notestine

2003

J Int Neuropsychol Soc

Self Cite

121

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The very high sensitivity and specificity of odor identification tasks in discriminating between Alzheimer's patients and normals suggests that they reflect the presence of underlying neuropathology. Significant neuropathological changes are seen in areas critical to processing olfactory information, even in the early stages of Alzheimer's disease (AD). The current study was designed to investigate whether performance on olfactory tasks (odor threshold and odor identification) was related to volumetric MRI measures of mesial temporal areas central to olfactory information processing and important in the neuropathology of AD. Participants were 8 male and 5 female patients with probable AD, and 10 male and 12 female normal age-matched controls, diagnosed at the UCSD Alzheimer's Disease Research Center. The study investigated correlations between volumetric measures of hippocampus, the parahippocampal gyrus and the amygdala, and the psychophysical measures of olfactory function. Robust relationships were observed between mesial temporal lobe volumes and olfactory functional measures. The finding of a strong relationship between left hippocampal volume and performance on the odor identification task (r 5 .85) is compatible with a left-hemisphere superiority for verbally mediated olfactory tasks. The findings suggest a neural substrate for the breakdown in functional performance on verbally mediated odor identification tasks in Alzheimer's disease and suggest the utility of quantitative MRI measures and psychophysical performance in the assessment of AD. These results support the potential clinical utility of inclusion of odor identification tests in diagnostic batteries for detecting AD. (JINS, 2003, 9, 459-471.)

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Cerebral structure on MRI, Part I: Localization of age-related changes

Cited by 358 publications

References 21 publications

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

The relation between global and limbic brain volumes on MRI and cognitive performance in healthy individuals across the age range

Schizophrenia Breakdown in the Well-regulated Lifelong Process of Brain Development and Maturation

Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: A structural MRI study

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