Cerebral Vascular Changes Secondary to Amphetamine Abuse in the Experimental Animal

Cl, Rumbaugh; Rt, Bergeron; Rl, Scanlan; Js, Teal; Segall, H D; Hc, Fang; McCormick, R

doi:10.1148/101.2.345

Cited by 137 publications

(40 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In adult rhesus monkeys, transient angiographic changes were seen within ten minutes of intravenous administration of methamphetamine. 12 The abnormalities reverted to normal by 24 hours, but were again noted at one week. Further analysis suggests, however, that such animal studies are not truly representative of the human disorder, in that all of the monkeys experienced significant hypertension, and there was a high incidence of cardiac dysrhythmia, focal cerebral ischaemia and diffuse cerebral edema, as well as gross subarachnoid haemorrhage.…”

mentioning

confidence: 93%

Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics.

Stoessl¹,

Young²,

Feasby³

1985

Stroke

View full text Add to dashboard Cite

SUMMARY We report two cases of serious intracerebral haemorrhage occurring in young women following their first use of oral medications containing catecholaminergic agents (phenylpropanolamine in combination with ephedrine or pseudoephedrine). Both women were previously well, and there was no evidence for systemic vasculitis, coagulopathy, aneurysm or arteriovenous malformation. Angiography in both cases, performed approximately forty hours following drug ingestion, revealed the beading pattern typical of that seen in previously reported cases of presumed amphetamine-induced "vasculitis." We believe that this arteriographic abnormality is non-specific and should not be construed as necessarily indicative of arteritis.

show abstract

mentioning

confidence: 93%

Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics.

Stoessl¹,

Young²,

Feasby³

1985

Stroke

View full text Add to dashboard Cite

show abstract

“…It is less well known that amphetamine abuse may also be associated with the occurrence of PAN-like vasculitis (Citron et al 1970, Rifkin 1977, Bostwick 1981. This association appears independent of HBsAg because although HBsAg might be expected in a high proportion of drug addicts, vasculitis indistinguishable from PAN can follow oral amphetamine abuse (Matick et al 1983) and develop in animals given the drug under sterile conditions (Rumbaugh et al 1971). Whether HBsAg, amphetamines, or both, were important in the pathogenesis of this case remains unclear.…”

Section: Discussionmentioning

confidence: 80%

Misleading Abdominal Computed Tomography in a Wasted Patient with Polyarteritis Nodosa

et al. 1985

View full text Add to dashboard Cite

“…Rumbaugh et al (25) reported on 6 drug abusers with dilatation of the ventricles and subarachnoid spaces, suggesting that cerebral atrophy can be related to drug abuse. In addition, certain experimental findings in animal models parallel these observations (24).…”

Section: Introductionmentioning

confidence: 71%

Brain Damage in Alcoholics without Neuropsychological Impairment. A Population Study

Mützell

1991

Upsala Journal of Medical Sciences

View full text Add to dashboard Cite

Computed tomography (CT) of the brain and neuropsychological assessment was performed in a random sample of 195 men to investigate the relationship between drinking of alcohol and brain damage. This sample from the general population was divided into subsamples on the basis of their self-reported loss of control over drinking, morning drinks and blackouts. The consumption of hepatotoxic drugs was also investigated. For this the material was divided into four groups with regard to both alcohol consumption and use of hepatotoxic drugs: Group LA, low or moderate alcohol consumption and no use of such drugs; IB, low or moderate alcohol consumption with use of such drugs; IIA, high alcohol consumption with no use of such drugs; and IIB, high alcohol consumption with use of such drugs. Group IIB was found to have a higher incidence of cortical and subcortical changes than group IA. Differences in CT variables were observed between the 4 groups IA-IIB, but there were no differences in the results of neuropsychological assessment.Thus, an alcoholic could have progressive cortical and subcortical changes without any neuropsychological impairment at all. Neither the duration of self-reported loss of control over drinking nor the amount of alcohol consumed per drinking occasion were found to be associated with cognitive impairment, but both showed a relationship to cortical and subcortical CT changes.

show abstract

Cerebral Vascular Changes Secondary to Amphetamine Abuse in the Experimental Animal

Cited by 137 publications

References 2 publications

Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics.

Intracerebral haemorrhage and angiographic beading following ingestion of catecholaminergics.

Misleading Abdominal Computed Tomography in a Wasted Patient with Polyarteritis Nodosa

Brain Damage in Alcoholics without Neuropsychological Impairment. A Population Study

Contact Info

Product

Resources

About