Cerebral vascular hamartoma in a geriatric cat

Martín-Vaquero, Paula; Moore, Sarah A.; Wolk, Kendra E.; Oglesbee, Michael

doi:10.1016/j.jfms.2010.12.006

Cited by 21 publications

(37 citation statements)

References 16 publications

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“…Vascular hamartomas are congenital malformations but often cause no clinical signs until later in life as illustrated in the geriatric cat suffering from a thalamocortic vascular hamartoma but with an onset of neurological symptoms at the age of 11 years. 9 In contrast, the foal in the current report presented much earlier, with clinical symptoms apparent shortly after birth; however, the localization and nature of the primary lesion remained unclear because diagnostic imaging techniques other than laryngeal endoscopy were not performed. The localization of the vascular hamartoma in the obex of the foal can be linked to the clinical signs observed because nuclei of the cranial nerves V, VII, IX, X, and XII originate from this brain region.…”

Section: Research-article2014mentioning

confidence: 63%

“…6 In contrast, previous reports in cats and dogs indicated a predilection for vascular hamartomas in the telencephalon and thalamocortex. 9,14,15 Immunohistochemical patterns of the vascular hamartoma in the geriatric cat 9 and in the foal were similar with endothelial lining cells strongly positive for factor VIII (endothelial cells) and a second population positive for SMA indicating pericyte origin. The presence of normal neuronal tissue between the hamartomatous vessels is considered the main feature for differentiating this non-neoplastic lesion from a hemangioma.…”

Section: Research-article2014mentioning

confidence: 83%

“…Cerebral and cerebellar vascular hamartomas have been reported in cats, 9,16 dogs, 14,15 and a calf 2 ; however, the calf was diagnosed as a disseminated cavernous hemangioma. A cerebellar vascular hamartoma affected a 16-month-old cat with clinical signs suggestive for a cerebellar lesion such as nystagmus, ataxia, and high-stepping gait.…”

Section: Research-article2014mentioning

confidence: 99%

“…16 Computed tomography (CT) was performed in a geriatric 11-year-old cat with neurological signs and revealed a mass in the thalamocortex. 9 The diagnosis of a vascular hamartoma was made histologically postmortem. Examination by CT revealed a well-demarcated mass in the frontal lobe, striatum, and thalamus of a 7-year-old dog resulting in the diagnosis of a cerebral vascular hamartoma postmortem.…”

Section: Research-article2014mentioning

confidence: 99%

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Vascular hamartoma in the central nervous system of a foal

et al. 2014

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Vascular hamartomas are non-neoplastic developmental anomalies of vessels. Cases of cerebral vascular hamartomas have been previously reported in dogs and cats. A 4-week-old Freiberger foal had shown persistent problems with breathing and swallowing since birth, and bilateral laryngeal paralysis was diagnosed. The foal subsequently developed left sided facial nerve paralysis and a secondary corneal ulcer in the left eye. Necropsy revealed a pinkish mass in the obex region of the brain. The mass was further investigated by histology and immunohistochemistry. Histologically, the mass consisted of many thin-walled, blood-filled vascular structures of variable diameter involving the white matter of the obex. The lining cells were immunohistochemically positive for factor VIII (von Willebrand factor) interpreted as endothelial cells. The endothelial lining showed also variable immunoreactivity for smooth muscle actin and vimentin. Normal neural parenchyma labeled with antibodies directed against glial fibrillary acidic protein and neuron-specific enolase was present between the vascular proliferations. A diagnosis of focal vascular hamartoma in the obex was made. The development of clinical signs is attributed to the compression of the surrounding neural parenchyma.

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Section: Research-article2014mentioning

confidence: 63%

Section: Research-article2014mentioning

confidence: 83%

Section: Research-article2014mentioning

confidence: 99%

Section: Research-article2014mentioning

confidence: 99%

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Vascular hamartoma in the central nervous system of a foal

et al. 2014

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“…Brain hamartoma in a 7-year-old dog (59), cerebral vascular hamartoma with petechiae and necrosis in an 11-year-old cat (44) and gastric hamartoma in another 11-year-old cat (62), are just a few examples. This proves that lesions can sometimes grow very slowly and cause clinical symptoms only in geriatric animals.…”

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confidence: 99%

Hamartoma: a rare developmental disorder

Bartyzel¹,

Max²,

Gruszczyńska³

et al. 2017

Medycyna Weterynaryjna

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SummaryHamartoma is a developmental disorder of various body parts and organs. It is characterized by a nonneoplastic growth of tissue with an uneven distribution and proportion of individual cells. Lesions progress for several years, but usually do not give clinical symptoms, and do not undergo malignant transformation. They occur alone or coexist with other defects, sometimes forming a characteristic clinical picture of a syndrome of congenital defects. Mutations in genes, such as PTEN, GLI3, SDH B/D, PIK3CA and ACT1, cause a dysfunction of the tumor suppressor gene and result in an increased neoplastic transformation. Hamartoma is a lesion between developmental disorders and benign tumors, which occurs frequently in humans, but is very rare in domestic animals. In a histopathological examination, however, it is diagnosed relatively often. In the veterinary literature, both hamartoma and choristoma are attributed mostly to errors in embryogenesis and are not considered as preneoplastic lesions.

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Hamartosis of the thoracolumbar vertebral column in a 3‐month‐old Rhodesian Ridgeback

Hauer¹,

Günther²,

Matiasek³

et al. 2023

Vet Record Case Reports

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This case report describes the clinical presentation, imaging diagnosis and histopathological findings of multiple osseous hamartomas in the thoracolumbar vertebral column of a 3‐month‐old Rhodesian Ridgeback puppy. The dog was presented due to progressive non‐painful, non‐ambulatory upper motor neuron paraparesis. Magnetic resonance imaging revealed diffuse T2‐weighted hyperintensities in the vertebral bodies of Th12, L4, S2 and the vertebral arch of Th13, and showed irregular and hyperostotic outer borders of the cortex. The diagnosis of multiple hamartomas was confirmed by histopathology showing bone cavities containing myxoid mesenchymal material, tortuous blood vessels and lipid and cartilaginous emboli in the bone marrow. This case emphasises the importance of keeping a hamartoma in mind as cause for neurological signs, especially in young animals.

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Cerebral vascular hamartoma in a geriatric cat

Cited by 21 publications

References 16 publications

Vascular hamartoma in the central nervous system of a foal

Vascular hamartoma in the central nervous system of a foal

Hamartoma: a rare developmental disorder

Hamartosis of the thoracolumbar vertebral column in a 3‐month‐old Rhodesian Ridgeback

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