Cerebral vasomotor reactivity in migraine: effect of patent foramen ovale and aerogenic microembolism

Khasiyev, Farid; Arsava, Ethem Murat; Topçuoğlu, Mehmet Akif

doi:10.1080/01616412.2020.1775015

Cited by 11 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Details of ultrasound measurement techniques can be found elsewhere. 23,24 Of note, BHI was calculated only if the duration of apnea was longer than 24 seconds. 25 Two patients had apnea duration less than 30 seconds, aMCI and AD one each.…”

Section: Ultrasoundmentioning

confidence: 99%

Cerebral vasomotor reactivity across the continuum of subjective cognitive impairment, amnestic mild cognitive impairment and probable Alzheimer's dementia: A transcranial Doppler and PET/MRI study

Saka

Atay

Akdemir

et al. 2022

J Cereb Blood Flow Metab

Self Cite

View full text Add to dashboard Cite

Cerebrovascular dysfunction has been suggested as a physiomarker of Alzheimer's disease (AD)-associated neuronal degeneration, but the underlying mechanisms are still debated. Herein cerebral vasomotor reactivity (VMR, breath-hold index: BHI), metabolic activity (lobar SUVs, FDG PET MRI), amyloid load (Centiloid score, Flutemetamol PET MRI), hemispheric cortical thickness, white matter lesion load and cerebral blood flow (ASL) were studied in 43 consecutive subjects (mean age: 64 years, female 13), diagnosed with subjective cognitive impairment (SCI, n = 10), amnestic mild cognitive impairment (aMCI, n = 15), and probable Alzheimer's dementia (AD, n = 18). BHI was significantly reduced in AD and aMCI patients compared to SCI subjects. A highly significant inverse correlation was found between BHI and the centiloid score (r = −0.648, p < 0.001). There was moderate positive correlation between BHI and frontal, temporal and parietal FDG SUV and ASL values, and a borderline negative correlation with age and white matter lesion volume. The link between amyloid burden and VMR was independent and strong in linear regression models where all these parameters were included (β from –0.580 to –0.476, p < 0.001). In conclusion, our study confirms the negative association of cerebral amyloid accumulation and vasomotor reactivity in Alzheimer's disease with the most direct data to date in humans.

show abstract

Section: Ultrasoundmentioning

confidence: 99%

Cerebral vasomotor reactivity across the continuum of subjective cognitive impairment, amnestic mild cognitive impairment and probable Alzheimer's dementia: A transcranial Doppler and PET/MRI study

Saka

Atay

Akdemir

et al. 2022

J Cereb Blood Flow Metab

Self Cite

View full text Add to dashboard Cite

show abstract

“…The incidence of mild shunts in migraine patients was higher than that in control, although a large proportion of normal people had massive shunts )p=0.022(. In the migraine group, mild of RLS were found in 150 21 )39.62( 0.002 RLS -right-to-left shunt, MA -migraine patients without aura patients )28.41%(, moderate of RLS were found in 46 patients )8.71%(, and massive of RLS were found in 96 patients )18.18%(. However, in the control group, mild of RLS were found in 16 patients )22.50%(, moderate of RLS were found in 4 patients )5.60%(, and massive of RLS were found in 6 patients )8.50%(.…”

Section: Results Incidence Of Rls In Patients With Migraine and Controlmentioning

confidence: 97%

“… 1 , 2 The deeper mechanism linking migraine, RLS, and stroke may be compromised dynamic cerebral autoregulation. 18 Moreover, the mechanism of RLS - induced migraine mainly involves the following aspects: cerebral endothelial dysfunction, 19 higher breath-holding index, 20 cerebral vasomotor reactivity, 21 local arterial area hypoperfusion, 22 , 23 microembolism (venous thrombosis, fat emboli or concentration of metabolites), and aerogenic microembolism and its involvement with subclinical cerebral ischemia. 21 , 24 Therefore, to help doctors clinically select migraine patients especially that with RLS, it is crucial to determine the detailed characteristics and clinical manifestations of migraine for the prediction of RLS, although European consensus does not recommend RLS screening for all migraine sufferers.…”

Section: Discussionmentioning

confidence: 99%

Relationship between right-to-left shunt detected by c-TCD and clinical characteristics in migraine patients

Shi

et al. 2022

NSJ

View full text Add to dashboard Cite

“…Some clinical studies have predicted that nasal oxygen might partly reduce the severity of migraine 8-11,29−31 . One main hypothesis for PFO-migraines is that PFO induced RLS leads to mixing of venous and arterial blood, resulting in decreased delivery of oxygen content to the brain 15,32,33 . Furthermore, the transient variation of cerebral oxygen content in the setting of normal perfusion may contribute to hypo-metabolism and then trigger a migraine 34,35 .…”

Section: Nbo May Inhibit Pfo-migrainementioning

confidence: 99%

Normobaric oxygen may attenuate patent foramen povale-related migraine

Lan

Dandu

Ding

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Existing methods on correcting patent foramen ovale (PFO)-mediated migraine (PFO-migraine) are not satisfactory. Herein, the effect of normobaric oxygenation (NBO) on inhibiting PFO-migraine was analyzed. Methods: Patients with PFO confirmed by Transesophageal Ultrasound were enrolled in this real-world self-control study consecutively. Baseline data of arterial oxygen partial pressure (PaO2) from their blood gas was compared to PaO2 values from 20 volunteers without a PFO. Patients with PFO-migraine underwent NBO (8L/min. for 1h/q8h) treatment through a mask. The clinical symptoms, results of blood gas, and electroencephalograph (EEG) pre-and post-NBO were compared. Results: A total of 67 eligible patients entered final analysis, of whom 39 had PFO-migraines. Of those 39 patients with PFO-migraines, a small-aperture PFO accounted for 36%. The PaO2 in patients with PFO-migraine at baseline were lower than that in non-PFO volunteers. After one round of NBO treatment, 74.4% of all PFO-migraine patients demonstrated dramatic headache attenuation, and their arterial PaO2 increased remarkably (p<0.01). This increase in PaO2 was maintained for 4 hours and then gradually declined. EEG data in 12 patients prior to and post-NBO treatment were compared. EEG maps prior to NBO treatment demonstrated significant abnormal slow waves. After NBO treatment, the abnormal slow waves disappeared on EEG maps. Conclusions: PFO-mediated right-to-left shunts induce arterial hypoxemia resulting in brain hypoxia, which may be the pathological link between PFO and migraines. Patients with PFO–migraine may benefit from NBO treatment.

show abstract

Cerebral vasomotor reactivity in migraine: effect of patent foramen ovale and aerogenic microembolism

Cited by 11 publications

References 41 publications

Cerebral vasomotor reactivity across the continuum of subjective cognitive impairment, amnestic mild cognitive impairment and probable Alzheimer's dementia: A transcranial Doppler and PET/MRI study

Cerebral vasomotor reactivity across the continuum of subjective cognitive impairment, amnestic mild cognitive impairment and probable Alzheimer's dementia: A transcranial Doppler and PET/MRI study

Relationship between right-to-left shunt detected by c-TCD and clinical characteristics in migraine patients

Normobaric oxygen may attenuate patent foramen povale-related migraine

Contact Info

Product

Resources

About