Cerebral vasomotor reactivity in neurodegenerative diseases

Smoliński, Łukasz; Członkowska, Anna

doi:10.1016/j.pjnns.2016.07.011

Cited by 31 publications

(23 citation statements)

References 85 publications

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“…First, the BHI was obtained by calculating the percentage change from MFV during baseline and the maximal increase in flow velocity at the end of the breath hold. This percentage change was divided by 30 seconds (or the actual time subjects held their breath) . Second, BHAI and CVR were calculated by linear regression of the most linear portion of the MFV change during the breath‐hold maneuver …”

Section: Methodsmentioning

confidence: 99%

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Cerebrovascular Reactivity Impairment in Preclinical Alzheimer's Disease

Alwatban

Murman

Bashford

2019

Journal of Neuroimaging

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BACKGROUND AND PURPOSE: A substantial overlap exists between declines in cerebral vasoreactivity (CVR) and symptomatic Alzheimer's disease (AD). CVR can be quantified using transcranial Doppler (TCD) measurement of cerebral blood flow velocities (CBFV) in the middle cerebral artery (MCA) with CO 2 as a vasodilatory stimulus. The breath-hold acceleration index (BHAI) is a new, more reliable measure of CVR developed recently in our laboratory. Our primary goal is to explore the possibility of using TCD for asymptomatic AD screening. METHODS:A pilot study population was divided into three groups: 9 healthy control subjects, 8 subjects identified as preclinical AD, and 10 patients diagnosed with prodromal or mild AD. Control subjects had a Clinical Dementia Rating (CDR) score of 0 without elevated amyloid-β (Aβ) on amyloid positron emission tomography (PET) imaging, preclinical AD subjects had CDR = 0 with elevated Aβ, and prodromal to mild AD subjects had CDR scores ࣙ.5 and elevated Aβ. CVR was calculated using two indices: the conventional breath-holding index (BHI) and the new BHAI. TCD parameters between the three groups were compared. RESULTS: BHAI was able to distinguish between 9 normal control subjects and 8 preclinical-AD subjects with high statistical significance (P < .001). BHI and pulsatility index were able only to distinguish AD from healthy and preclinical subjects (P < .001). CONCLUSIONS: In this exploratory pilot study, CVR was significantly decreased in preclinical, prodromal, and mild AD subjects as compared to the healthy group. Lower CVR in the preclinical AD group was detected using the new BHAI index but not the conventional BHI index.

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Section: Methodsmentioning

confidence: 99%

“…Then, PI for each cardiac cycle was calculated by subtracting diastolic velocity ( Vd ) from the systolic velocity ( Vs ), and then dividing by the MFV . Finally, CVR was calculated using both BHI and BHAI indices …”

Section: Methodsmentioning

confidence: 99%

Cerebrovascular Reactivity Impairment in Preclinical Alzheimer's Disease

Alwatban

Murman

Bashford

2019

Journal of Neuroimaging

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“…(Koudriavtseva et al 2015) Many vasodilators and constrictors derived from the endothelium, neuronal innervation and glial cells are involved in CBF regulation. (Koudriavtseva et al 2015;Smolinski and Czlonkowska 2016) Also blood pressure plays an important role in brain perfusion control. (Smolinski and Czlonkowska 2016) Furthermore, vascular changes can occur in physiological conditions due to aging.…”

Section: Introductionmentioning

confidence: 99%

“…(Koudriavtseva et al 2015;Smolinski and Czlonkowska 2016) Also blood pressure plays an important role in brain perfusion control. (Smolinski and Czlonkowska 2016) Furthermore, vascular changes can occur in physiological conditions due to aging. (Liu et al 2012;Tsvetanov et al 2015) Correlations between age and CBF have been previously observed in MS patients, (Amann et al 2012) but no studies have investigated the relationship between age and CVR in MS.…”

Section: Introductionmentioning

confidence: 99%

Cerebrovascular reactivity and its correlation with age in patients with multiple sclerosis

Pelizzari

Laganà

Baglio

et al. 2019

Brain Imaging and Behavior

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We assessed cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) within gray matter (GM), normal appearing white matter (NAWM) and white matter (WM) lesions in a group of multiple sclerosis (MS) patients. Furthermore, correlations between CBF, CVR and age were investigated. 31 MS patients and 25 healthy controls (HC) were examined on a 1.5 T MRI scanner, using pseudo-continuous arterial spin labeling MRI. MS vs HC CBF and CVR differences were assessed in GM regions of interest (i.e. resting state networks and vascular territories), and within WM. Correlations between CBF/CVR and age were then computed for MS and HC groups. Whereas no significant CBF and CVR differences were observed between MS and HC in any of the considered brain areas, significantly lower CBF was found in WM lesions with respect to NAWM (p < 0.001) in MS patients. Furthermore, CVR was significantly correlated with age in HC, but not in MS patients. The relatively low-grade of inflammation of our MS cohort may be associated with the observed lack of significant CVR differences between MS patients and HC. The loss of correlation between CVR and age in the MS group suggests that CVR may be influenced by MS-related factors.

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“…23,24 Moreover, in Alzheimer's disease, reduced CVR has been demonstrated with many techniques, including BOLD, ASL and TCD. 25 Marshall et al hypothesized that CVR might be reduced in MS due to habituation of cerebral vasculature to chronically increased nitric oxide concentrations. 18 However, nitric oxide seems essential for hypercapnia-induced cerebral vasodilation, 26 and consequently for CVR, and we were not able to find any previous evidence that nitric oxide, when chronically increased, like in MS, 27 has an opposing effect.…”

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confidence: 99%