Cerebral Vasospasm-Clinical and Experimental Evidence

Pool, James L.

doi:10.1001/jama.1958.02990300025005

Cited by 66 publications

(17 citation statements)

References 4 publications

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“…1,14,15,19) Intraoperative topical, i.e., intracisternal papaverine application has been used to prevent vasospasm which can be caused by both intraoperative arterial manipulation and subarachnoid hemorrhage. 8,20) Topical papaverine is also used in non-neurosurgical operations in which vessel manipulation may induce vascular spasm, such as infant renal surgery. 7) Transient ipsilateral pupillary dilation (mydriasis) with pupillary areflexia after intracisternal and intraarterial papaverine application is a common benign side effect.…”

Section: Introductionmentioning

confidence: 99%

Facial Nerve Palsy After Intracisternal Papaverine Application During Aneurysm Surgery

Lang

Neugebauer

et al. 2002

Neurol. Med. Chir.(Tokyo)

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A 61-year-old woman suffered transient mydriasis and prolonged facial nerve palsy after intracisternal papaverine application subsequent to elective clipping of an unruptured middle cerebral artery aneurysm. The mydriasis resolved within 90 minutes, but the facial nerve dysfunction persisted for 2 months before complete recovery. Prolonged irrigation of the cisterns may have washed the papaverine into contact with the facial nerve. This case supports previously reported evidence of a possible effect of topical intracisternal papaverine hydrochloride application on the facial nerve.

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Section: Introductionmentioning

confidence: 99%

Facial Nerve Palsy After Intracisternal Papaverine Application During Aneurysm Surgery

Lang

Neugebauer

et al. 2002

Neurol. Med. Chir.(Tokyo)

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“…No appreciable dilatation of the major arteries has been detected even under conditions where the cerebral tissue suffered greatly from deficiency of blood supply either locally or within larger cerebral areas [24], Thus, it was concluded that major arteries of the brain possess specific functions and do not compensate appreciably for a deficient blood supply; their most typical response is vasoconstriction. In accordance with this there is a large body of experimental evidence and numerous clinical observations [6,12,27,33,38,40,48] indicating that vasospasm most readily develops in the larger arteries of the brain.…”

Section: Spasm Of Cerebral Arteries In Relation To Their Functional Cmentioning

confidence: 70%

“…The angiographic technique de veloped during that period allowed direct ob servation of spasms of the large cerebral ar teries [38,40]. This resulted in a conceptual shift in the knowledge of cerebral vasospasm which became widely considered as a proba ble cause of cerebrovascular disturbances.…”

Section: Introductionmentioning

confidence: 99%

The Nature of Cerebral Vasospasm

Mchedlishvili¹

1981

J Vasc Res

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The article comprises mainly the personal views of the author on the following aspects of cerebral vasospasm: the definition of vasospasm; historical physiological concepts of cerebral bloodflow regulation; relation of spasm development in cerebral arteries to their functional behavior during regulation of cerebral blood flow; the essence of vasospasm from the standpoint of smooth muscle physiology; physiological stimuli involved in its development; the disturbances in plasmatic membrane function and intracellular processes of smooth muscles inducing vasospasm; systems approach to development which may assist in systematization of data and in efficiency and direction of further research.

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“…It seems highly unlikely that the vertebral artery suddenly "snapped shut." Case 3.-A 58-year-old man complained of sudden onset of severe headache and vomiting on July 17,1971. He was admitted to Mayo Clinic Neurology Hospital Service.…”

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confidence: 99%

Cerebral Vasospasm and Ruptured Intracranial Aneurysm

Millikan¹

1975

Archives of Neurology

127

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The literature concerning cerebral vasospasm associated with subarachnoid hemorrhage (SAH) due to ruptured intracranial aneurysm contains no definitive study of patients to determine whether there is (1) any clinical picture consistently present coincident with known cerebral vasospasm, (2) any relationship between mortality and known vasospasm, and (3) any relationship between serious brain damage (morbidity) and known vasospasm. To answer these important questions, experience with 198 consecutive acute SAH patients (every patient had a cerebral angiogram demonstrating one or more intracranial aneurysms) was studied. The experience with these 198 consecutive patients led to the conclusions that (1) there is no clinical picture consistently present coincident with known cerebral vasospasm; (2) cerebral vasospasm has no effect on the mortality from SAH due to ruptured aneurysm; and (3) there is no relationship between the frequency and severity of the complications from surgical or conservative treatment and the presence or absence of vasospasm.

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Cerebral Vasospasm-Clinical and Experimental Evidence

Cited by 66 publications

References 4 publications

Facial Nerve Palsy After Intracisternal Papaverine Application During Aneurysm Surgery

Facial Nerve Palsy After Intracisternal Papaverine Application During Aneurysm Surgery

The Nature of Cerebral Vasospasm

Cerebral Vasospasm and Ruptured Intracranial Aneurysm

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