Cerebral vein and dural sinus thrombosis in adults in Isfahan, Iran: frequency and seasonal variation

Janghorbani, Mohsen; Zare, Mohammad Reza; Saadatnia, Mohammad; Mousavi, Seyyed Ali; Mojarrad, Mehdi; Asgari, Elaheh

doi:10.1111/j.1600-0404.2007.00915.x

Cited by 59 publications

(67 citation statements)

References 19 publications

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“…This hypothesis is supported by our finding that the severity of the clinical condition of patients with CVT has also decreased over time (less coma and focal neurological deficits) and the increased incidence of CVT over time. 3,10 In addition, if the analysis was restricted to studies published after 2000-at which time use of computed tomography venography and MRI had become widespread-there was no longer a correlation between mortality and time of the study.…”

Section: Discussionmentioning

confidence: 99%

Declining Mortality in Cerebral Venous Thrombosis

Coutinho

Zuurbier

Stam

2014

Stroke

164

104

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We extracted data on study design, demographics, baseline clinical manifestations, risk factors, ancillary investigations, treatment, and Background and Purpose-Cerebral venous thrombosis (CVT) is nowadays considered a disease with a good outcome in most cases, but in the past, these patients were thought to have a grave prognosis. We systematically studied the apparent decline in mortality of patients with CVT over time. Methods-A systematic review of the literature (MEDLINE and EMBASE) was performed. Studies with ≥40 patients with CVT that reported mortality at discharge or follow-up were eligible. Duplicate publications based on the same patient cohort were excluded. Studies were ranked according to the year halfway the period of patient inclusion. Two of the authors independently screened all eligible studies. Results-We screened 4585 potentially eligible studies, of which 74 fulfilled the selection criteria. The number of patients per study varied from 40 to 706 (median, 76). Data from 8829 patients with CVT, included from 1942 to 2012, were analyzed. The average age was 32.9 years, and 64.7% were women. There was a significant inverse correlation between mortality and year of patient recruitment (Pearson correlation coefficient, −0.72; P<0.001). In a sensitivity analysis, the correlation remained significant after exclusion of studies published before 1990, retrospective studies, or single-center studies. Both the frequency of focal neurological deficits and coma also decreased significantly over time (correlation coefficient, −0.50 and −0.52). Conclusions-There is a clear trend in declining mortality among patients with CVT over time. Possible explanations are improvements in treatment, a shift in risk factors, and, most importantly, the identification of less severe cases by improved diagnostic methods.

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Section: Discussionmentioning

confidence: 99%

Declining Mortality in Cerebral Venous Thrombosis

Coutinho

Zuurbier

Stam

2014

Stroke

164

104

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“…8 A clinic-based registry in Iran reported an annual CVT incidence of 12.3 per million. 9 In a series of intracerebral hemorrhage (ICH) cases in young people, CVT explained 5% of all cases. 9 …”

Section: Epidemiology and Risk Factors For Cvtmentioning

confidence: 99%

Diagnosis and Management of Cerebral Venous Thrombosis

Saposnik¹,

Barinagarrementería²,

Brown³

et al. 2011

Stroke

1,697

1,229

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Background— The purpose of this statement is to provide an overview of cerebral venous sinus thrombosis and to provide recommendations for its diagnosis, management, and treatment. The intended audience is physicians and other healthcare providers who are responsible for the diagnosis and management of patients with cerebral venous sinus thrombosis. Methods and Results— Members of the panel were appointed by the American Heart Association Stroke Council's Scientific Statement Oversight Committee and represent different areas of expertise. The panel reviewed the relevant literature with an emphasis on reports published since 1966 and used the American Heart Association levels-of-evidence grading algorithm to rate the evidence and to make recommendations. After approval of the statement by the panel, it underwent peer review and approval by the American Heart Association Science Advisory and Coordinating Committee. Conclusions— Evidence-based recommendations are provided for the diagnosis, management, and prevention of recurrence of cerebral venous thrombosis. Recommendations on the evaluation and management of cerebral venous thrombosis during pregnancy and in the pediatric population are provided. Considerations for the management of clinical complications (seizures, hydrocephalus, intracranial hypertension, and neurological deterioration) are also summarized. An algorithm for diagnosis and management of patients with cerebral venous sinus thrombosis is described.

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“…According to data gathered related with hospitalized patients, the incidence of CVST is approximately 2/100,000/years (3,4,5). CVST is often caused by malignancy, infection, pregnancy, puerperium, systemic diseases, dehydration, oral contraceptive (OCs) use, and coagulopathy; however, the etiology is unknown in 30% of patients (6,7,8).…”

Section: Introductionmentioning

confidence: 99%

Clinical Features of Cerebral Venous Sinus Thrombosis

Eryıldız¹,

Özdemi̇r²

2017

tnd

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Amaç: Serebral venöz sinüs trombozunun (SVST) altında yatan nedenleri, hastalığın karşımıza çıkış şekillerini, görüntüleme özelliklerini, tedavi tiplerini ve hastaların akıbetlerini araştırmayı amaçladık. Gereç ve Yöntem:Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Nöroloji İnme Merkezi'nde Nisan 2011-Eylül 2016 tarihleri arasında SVST tanısı ile takip ettiğimiz hastaların demografik verileri, başvuru belirti ve bulguları, nörogörüntüleme ve laboratuvar incelemeleri, hastalığın altında yatan nedenleri, tedavi şekillerimiz ve yine hastaların hastaneden çıkarıldıkları sıradaki nörolojik fonksiyonları geriye dönük olarak incelendi. Bulgular: SVST tanılı 25'i kadın toplam 31 hasta çalışmaya dahil edildi. Hastaların yaş ortalaması 43,7 idi (standart sapma: 16,4 değişim aralığı: 22-78). En sık görülen belirti baş ağrısı olup, en sık altta yatan nedenler gebelik ve lohusalık, en sık tutulan sinüs ise transvers sinüs idi. Hastaların büyük kısmının (29/31, %93,6) antikoagüle edildiği ve taburcu edildikleri sıradaki Modifiye Rankin Skala skorlarının 2 ya da altında olduğu görüldü.Sonuç: Bu çalışmada inme merkezimizde takip ettiğimiz SVST tanılı hastaların özelliklerini inceledik ve hastaların akıbetlerinin önceden sanılanın aksine iyi olduğunu gösterdik. Ancak, tedavi şekilleri ve hastalığın akıbeti ile ilgili daha kesin sonuçlara ulaşabilmek için daha geniş kohortlu ileriye dönük çalışmalara ihtiyaç vardır.Anahtar Kelimeler: Venöz tromboz, sinüs trombozu, inme, inme alt tipi Objective: To investigate the predisposing factors for cerebral venous sinus thrombosis (CVST), presenting patterns of the disease, imaging characteristics, types of treatment, and outcomes of patients. Materials and Methods:Retrospectively, between April 2011 and September 2016 at Eskisehir Osmangazi Stroke Center, the demographic data, symptoms and findings, neuroimaging and laboratory findings of patients with CVST were collected. Additionally, predisposing factors for the disease, treatment strategies, and the neurologic functions of patients at discharge were examined. Results:Thirty-one patients with CVST were included in the study, 25 of whom were female. The mean age of the patients was 43.7 years (standard deviation: 16.4; range, 22-78 years). The most common symptom was headache and the most common predisposing factors were pregnancy and puerperium. Also, transverse sinus was the most common thrombosed sinus. In the majority of patients (29/31, 93.6%), anticoagulation was applied and the Modified Rankin Scale score was 2 or below. Conclusion:In this study, we detailed the characteristics of patients with CVST at our stroke center and contrary to previous knowledge, we showed that the outcomes of patients were good. However, to achieve more accurate conclusions about treatment strategies and outcomes, we need prospective studies with larger cohorts.

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Cerebral vein and dural sinus thrombosis in adults in Isfahan, Iran: frequency and seasonal variation

Abstract: The findings of this study show the CVST frequency in adults. More women than men are present with CVST and its frequency increased during autumn.

Cited by 59 publications

References 19 publications

Declining Mortality in Cerebral Venous Thrombosis

Declining Mortality in Cerebral Venous Thrombosis

Diagnosis and Management of Cerebral Venous Thrombosis

Clinical Features of Cerebral Venous Sinus Thrombosis

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