2014
DOI: 10.1002/ajh.23809
|View full text |Cite
|
Sign up to set email alerts
|

Cerebral vein thrombosis in patients with Philadelphia‐negative myeloproliferative neoplasms An European Leukemia Net study

Abstract: To investigate the characteristics and clinical course of cerebral vein thrombosis (CVT) in patients with myeloproliferative neoplasms (MPN) we compared 48 patients with MPN and CVT (group MPN-CVT) to 87 with MPN and other venous thrombosis (group MPN-VT) and 178 with MPN and no thrombosis (group MPN-NoT) matched by sex, age at diagnosis of MPN (±5 years) and type of MPN. The study population was identified among 5,500 patients with MPN, from January 1982 to June 2013. Thrombophilia abnormalities were signific… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

5
54
2

Year Published

2014
2014
2024
2024

Publication Types

Select...
6
2

Relationship

4
4

Authors

Journals

citations
Cited by 44 publications
(61 citation statements)
references
References 21 publications
5
54
2
Order By: Relevance
“…In a series of 48 patients with MPN and CVT, diagnosis of MPN was concomitant to that of CVT in 46% of the patients, and 81% of JAK2 V617F positivity was observed [28]. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In a series of 48 patients with MPN and CVT, diagnosis of MPN was concomitant to that of CVT in 46% of the patients, and 81% of JAK2 V617F positivity was observed [28]. …”
Section: Discussionmentioning
confidence: 99%
“…About 30% of vascular events in Ph-negative MPN patients are VTE [27], which generally present as lower limb deep vein thrombosis or pulmonary artery embolism. However, in Ph-negative MPN, VTE characteristically occurs in uncommon locations such as splanchnic veins, including hepatic veins (presenting Budd-Chiari syndrome), portal and mesenteric veins, or, less frequently, cerebral veins or sinuses [15,28]. In patients with MPN, the prevalence of CVT is 1% or less [23,29,30], and among patients with CVT, MPN is concomitantly diagnosed in 3-7% of cases [23,31,32].…”
Section: Discussionmentioning
confidence: 99%
“…82 Cerebral vein thrombosis is a rare, life-threatening event that leads to a concurrent diagnosis of a MPN in 2% to 7% of cases; the estimated prevalence among all MPN is 1% to 2%. [83][84][85] A slightly higher frequency of cerebral vein thrombosis has been reported in PV than ET. 84 Resistance/refractoriness to first-line treatment Over time, 10% to 15% of patients on hydroxyurea develop hematologic and extrahematologic (painful leg ulcers, skin cancers, or extensive dermatitis, and fever) toxicities 86 and have to stop the drug or use a suboptimal dose (Table 6 87,88 ).…”
Section: Special Situations Of Interest Thrombosis In Unusual Sitesmentioning
confidence: 99%
“…Intriguingly, BCS, which is caused by thrombotic obstruction of the hepatic veins and/ or the suprahepatic inferior vena cava, has been attributed to an MPN in 41 % of cases, while 30 % of patients with portal vein thrombosis have a diagnosis of MPN (11). The prevalence of CVST in MPN patients is 1 %, and in nearly half of the patients, the diagnoses are made concomitantly (12).…”
Section: Discussionmentioning
confidence: 99%
“…However, MPN patients were not included in these studies (28). Venous thromboses in atypical locations such as CVST are associated with a high risk of recurrence and patients should therefore be evaluated for long-term anticoagulation with VKA (12,28). Intriguingly, a most recent publication supports the use of longterm anticoagulation for secondary prevention of MPN-associated VTE, regardless of the site of the initial thrombotic event (29).…”
Section: Polycythemia Veramentioning
confidence: 99%