Cerebral venous thrombosis: comparing characteristics of infective and non-infective aetiologies: a 12-year retrospective study

Korathanakhun, Pat; Petpichetchian, Wongchan; Sathirapanya, Pornchai; Geater, Sarayut Lucien

doi:10.1136/postgradmedj-2015-133592

Cited by 24 publications

(22 citation statements)

References 11 publications

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“…Additional proof that infections cause thrombosis comes from associations between infection and subsequent thrombosis in the same specific site, reported for various morbidities, e.g. Lemierre syndrome and cerebral vein thrombosis (Korathanakhun et al , ; Johannesen & Bodtger, ; Yildiz et al , ).…”

Section: Discussionmentioning

confidence: 96%

Antibiotic use as a marker of acute infection and risk of first and recurrent venous thrombosis

et al. 2017

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A role for transient infections in the aetiology of venous thrombosis (VT) has been suggested. This study aimed to determine whether individuals who receive antibiotic treatment (as a proxy for infections) have an increased risk of first and recurrent VT and whether infections should be seen as a provoking risk factor for VT. We used the self-controlled case series method to study the risk of first VT during antibiotic prescriptions. The risk of recurrent VT during antibiotic use was estimated by of time-dependent Cox-regression. A total of 2547 patients with a first VT were included and followed for a median of 5·9 years for recurrence (1999-2010), in whom 114 first events occurred during antibiotic use. We found a five-fold increased risk of first VT during antibiotic treatment: [incidence-rate-ratio 5·0; 95% confidence interval (CI), 4·0-6·1]. Antibiotic use was associated with a 2·0-fold (95% CI, 1·1-4·0) increased risk of recurrent VT. Patients with an unprovoked first VT who used antibiotics shortly before this event, had a similar risk of recurrence as patients with a provoked first VT (adjusted hazard ratio 1·1; 95% CI, 0·7-1·7). Individuals who receive antibiotics have an increased risk of first and recurrent VT and infections should be considered a provoking risk factor for VT.

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Section: Discussionmentioning

confidence: 96%

Antibiotic use as a marker of acute infection and risk of first and recurrent venous thrombosis

et al. 2017

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“…In our case, surgical treatment was not considered due to the patient's age and comorbidities, along with the rapid improvement of the symptoms with conservative treatment. The evidence available regarding LS complicated with cerebral venous thrombosis (CVT) is scarce, and mostly based in case reports or case series (3)(4)(5)(6). In one of the largest case series of infection-associated CVT, all patients were treated with antibiotics combined with local surgical drainage or resection of the infected site; however, 50% of these patients showed an unfavourable outcome (5).…”

Section: Discussionmentioning

confidence: 99%

“…The evidence available regarding LS complicated with cerebral venous thrombosis (CVT) is scarce, and mostly based in case reports or case series (3)(4)(5)(6). In one of the largest case series of infection-associated CVT, all patients were treated with antibiotics combined with local surgical drainage or resection of the infected site; however, 50% of these patients showed an unfavourable outcome (5). In a case series of infectious CVT in pediatric population, all cases were treated with surgery and antibiotic therapy, and the reported outcome was favourable in all cases, although almost half of patients developed mild hearing impairment (4).…”

Section: Discussionmentioning

confidence: 99%

“…The most commonly involved bacteria is Fusobacterium necrophorum but other bacteria such as fusobacteria, Streptococcus, Staphylococcus, and Enterococcus are commonly found in cultures. Although the internal jugular vein is the most commonly affected vein, a few case reports have been published with thrombosis of other veins, such as the facial vein or transverse sinus (3)(4)(5)(6). In a recent systematic review of LS, a large proportion of cases had septic emboli in the lungs (2).…”

Section: Introductionmentioning

confidence: 99%

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Torcular herophili and lateral sinus thrombosis: An atypical presentation of Lemièrre's syndrome

Baltasar-Corral

Martín‐Rojas

Parra-Virto

et al. 2019

IRDR

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Lemièrre's syndrome (LS) is an uncommon disease characterized by septic thrombophlebitis of the jugular vein in the context of otorhinolaryngologic infections. These patients are often young and the pharyngotonsillar infection is the most frequent primary focus, but other foci like acute otitis media or otomastoiditis have been described. Although the internal jugular vein is the most commonly affected site, a few case reports have been published with thrombosis of other veins, such as the facial vein or transverse sinus. We report the case of a 93-year-old woman with an atypical presentation of LS presenting with thrombophlebitis of the internal jugular vein, transverse sinuses and Herophili torcula after an acute otitis media complicated with acute otomastoiditis. Infectious cerebral venous thrombosis (CVT) is rare and accounts for 6-12% of the total in large adult series and is usually associated to otorhinolaryngologic infections. CVT is an atypical presentation of LS that can be potentially lethal, especially during the acute phase. For this reason, clinical suspicion and early treatment are vital to improve the prognosis of these patients. Although surgical treatment is recommended in cases of LS complicated with CVT, conservative management with antibiotics and anticoagulation lead to ad integrum restitutio without neurological sequelae in our case, suggesting that surgical treatment may not be necessary in all cases of LS complicated with CVT.

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“…Craniofacial infections were a common cause of CVST in the preantibiotic era. Their current mortality rate ranges between 5% and 10% 1 3…”

mentioning

confidence: 99%

Cerebral venous sinus thrombosis secondary to otomastoiditis

Villamar

Lee

2017

Postgraduate Medical Journal

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Cerebral venous thrombosis: comparing characteristics of infective and non-infective aetiologies: a 12-year retrospective study

Abstract: Cavernous sinus thrombosis is a distinctive clinical presentation of IACVT, whereas focal neurological syndrome is a hallmark feature of NIACVT. Paracranial fungal infections are highly virulent and frequently associated with intracranial complications.

Cited by 24 publications

References 11 publications

Antibiotic use as a marker of acute infection and risk of first and recurrent venous thrombosis

Antibiotic use as a marker of acute infection and risk of first and recurrent venous thrombosis

Torcular herophili and lateral sinus thrombosis: An atypical presentation of Lemièrre's syndrome

Cerebral venous sinus thrombosis secondary to otomastoiditis

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