Cerebral venous thrombosis in an adolescent with ulcerative colitis

Biology of the TAM Receptors

“…Correspondingly, several lines of evidence suggest that diminished TAM signaling may contribute to human autoimmunity (Rothlin and Lemke 2010). There is an anecdotal medical literature that ties low circulating levels of Pros1 to IBDs (Song et al 2000;Zezos et al 2007;Cakal et al 2010;Diakou et al 2011) and a much larger literature that establishes an association between low Pros1 and SLE (Song et al 2000;Brouwer et al 2004;Meesters et al 2007). A recent analysis of a 107-patient SLE cohort found that levels of free protein S-but not Gas6-were significantly lower in SLE patients with a history of serositis, neurologic disorder, hematologic disorder, and immunologic disorder, and that low Pros1 levels were correlated with other disease-associated risk factors such as reductions in the complement proteins C3 and C4 (Suh et al 2010).…”

Clinical Profile of Patients with Cortical venous Thrombosis: A Hospital Based Study

“…[18] IJV abnormalities may change the hemodynamics of cerebral venous outflow, leading to insufficient venous drainage, and subsequently causing CSVT. In a study performed by Jia et al, [19] found that among 51 consecutive CSVT cases with unknown etiologies, 61% of the cases (31/51) had an IJV abnormality; furthermore, almost all the CSVT occurred on the same side as the IJV lesions, which strongly suggests a close association between IJV abnormalities and CSVT.…”

Cerebral sinus thrombosis in ulcerative colitis

“…1 Cerebral venous thrombosis (CVT) is a rare and serious lifethreatening condition with a wide spectrum of presenting symptoms and signs. It accounts for >1% of all strokes 2 and its prognosis is directly related to the time of diagnosis and appropriate treatment. In May 2010 we observed a 40-year-old Caucasian man presenting with asthenia and marked iron deficiency anemia (IDA) with a hemoglobin (Hb) value of 5.5 g/dL and low ferritin (7 ng/ mL: normal range [NR] 17-322) that required infusion of three concentrated blood red cell units.…”