Cerebral venous thrombosis in Behçet's disease

Wechsler, B.; Vidailhet, M; Piette, Jean‐Charles; Bousser, M. G.; Isola, B. Dell; Blétry, O; Godeau, P

doi:10.1212/wnl.42.3.614

Cited by 191 publications

(95 citation statements)

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“…Since the first description of neurologic involvement in BD in 1941 (18), only single cases and small series of CVT in Saadoun et al patients with BD have been reported (7)(8)(9)(10)(11)(12)(13). Certain features of the disease have been hinted at in most of these reports.…”

Section: Discussionmentioning

confidence: 99%

“…Long-term followup has not been available in most reports. Treatment for dural venous sinus thrombosis involves anticoagulation, and some authors advocate the concurrent use of corticosteroids (3,13,22) and/or immunosuppressants (23) in patients with BD. In the present study, most of the patients rapidly improved following anticoagulation without severe hemorrhagic complications, underscoring the beneficial effect of such therapy.…”

Section: Discussionmentioning

confidence: 99%

“…However, its frequency is difficult to ascertain from the literature, which consists mainly of single case reports or short series (7)(8)(9)(10)(11)(12)(13). Nevertheless, CVT represents approximately 30% of all CNS lesions of BD (10,13).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cerebral venous thrombosis in Behçet's disease

Saadoun¹,

Wechsler²,

Resche-Rigon³

et al. 2009

Arthritis & Rheumatism

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142

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cerebral venous thrombosis in Behçet's disease

Saadoun¹,

Wechsler²,

Resche-Rigon³

et al. 2009

Arthritis & Rheumatism

Self Cite

142

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“…Arteries are less commonly involved. Seizures may occur owing to central venous thrombosis, but haemorrhage is uncommon [146].…”

Section: Behçet's Disease (Bd)mentioning

confidence: 99%

Immunotherapies for Neurological Manifestations in the Context of Systemic Autoimmunity

et al. 2016

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Neurological involvement is relatively common in the majority of systemic autoimmune diseases and may lead to severe morbidity and mortality, if not promptly treated. Treatment options vary greatly, depending on the underlying systemic pathophysiology and the associated neurological symptoms. Selecting the appropriate therapeutic scheme is further complicated by the lack of definite therapeutic guidelines, the necessity to differentiate primary neurological syndromes from those related to the underlying systemic disease, and to sort out adverse neurological manifestations caused by immunosuppressants or the biological agents used to treat the primary disease. Immunotherapy is a sine qua non for treating most, if not all, neurological conditions presenting in the context of systemic autoimmunity. Specific agents include classical immune modulators such as corticosteroids, cyclophosphamide, intravenous immunoglobulin, and plasma exchange, as well as numerous biological therapies, for example antitumor necrosis factor agents and monoclonal antibodies that target various immune pathways such as B cells, cytokines, and co-stimulatory molecules. However, experience regarding the use of these agents in neurological complications of systemic diseases is mainly empirical or based on small uncontrolled studies and case series. The aim of this review is to present the state-of-the-art therapies applied in various neurological manifestations encountered in the context of systemic autoimmune diseases; evaluate all treatment options on the basis of existing guidelines; and compliment these data with our personal experience derived from a large number of patients.

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“…La utilización a largo plazo de corticoides y anticoagulantes se ha demostrado útil para el tratamiento y prevención de las trombosis venosas cerebrales en la EB (22).…”

Section: Manifestaciones Vascularesunclassified