Cerebral Ventricular Enlargement in Non-Genetic Schizophrenia: a Controlled Twin Study

Reveley, Adrianne; Reveley, Michael A.; Murray, Robin M.

doi:10.1192/bjp.144.1.89

Cited by 212 publications

(61 citation statements)

References 3 publications

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“…The twin studies consistently report lateral ventricular enlargement as a difference between affected and nonaffected twins (Reveley et al 1982(Reveley et al ,1984Suddath et al 1990). Similar to our findings, the magnetic resonance imaging (MRI) twin study noted differences in the temporal lobes (Suddath et al 1990).…”

Section: Discussionsupporting

confidence: 89%

“…Investigating family members has the considerable advantage of optimal matching of affected (psychotic) and unaffected (control) individuals. Brain imaging studies using sibling pairs and twins have indicated that ventricular enlargement and reduction in the size of temporal lobe structures occurs in the affected individuals (De-Lisi et al 1986;Reveley et al 1982Reveley et al , 1984Suddath et al 1990;Weinberger et al 1981). A complementary strategy is to study multigenerational families in which two or more members have schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

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Temporal lobe abnormalities in multigenerational families with schizophrenia

Honer

Bassett

Smith

et al. 1994

Biological Psychiatry

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Brain structure in familial schizophrenia was studied with computerized tomography in 42 individuals from six multigenerational families. Sulcal enlargement in the lateral temporal cortex, and ventricular and cisternal enlargement in the medial temporal region were observed in psychotic individuals compared to unaffected family members. Genetic factors in familial schizophrenia may exert part of their effect through determining or altering temporal lobe structure.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Temporal lobe abnormalities in multigenerational families with schizophrenia

Honer

Bassett

Smith

et al. 1994

Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…[160][161][162] Sporadic cases are more likely to be winter-born 159,163,164 and have more electroencephalographic (EEG) abnormalities 153 and enlarged ventricles on CT scan or MRI. 152,165,166 Familial cases, on the other hand, have more neurological signs, 164,[167][168][169] poorer sustained attention performance; 170 cortical abnormalities on MRI 171 and reduced temporoparietal resting regional blood flow. 172 By and large, the F/S classification has not been successful in identifying homogeneous phenotype groups for genetic research.…”

Section: Subtypes Based On Putative Genetic Indicatorsmentioning

confidence: 99%

Subtyping schizophrenia: implications for genetic research

2006

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Phenotypic variability and likely extensive genetic heterogeneity have been confounding the search for the causes of schizophrenia since the inception of the diagnostic category. The inconsistent results of genetic linkage and association studies using the diagnostic category as the sole schizophrenia phenotype suggest that the current broad concept of schizophrenia does not demarcate a homogeneous disease entity. Approaches involving subtyping and stratification by covariates to reduce heterogeneity have been successful in the genetic study of other complex disorders, but rarely applied in schizophrenia research. This article reviews past and present attempts at delineating schizophrenia subtypes based on clinical features, statistically derived measures, putative genetic indicators, and intermediate phenotypes, highlighting the potential utility of multidomain neurocognitive endophenotypes.

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“…One early study [97] compared monozygotic and dizygotic twins for ventricular size and found high heritability.…”

Section: Endophenotypesmentioning

confidence: 99%

Genetics of Schizophrenia and other Psychotic Disorders

Pepper¹,

Cardno²

2014

CPSR

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Abstract:Research into the genetic basis of schizophrenia is advancing rapidly. This review gives a broad overview of results from successive phases of studies in this field, linking these with recent findings and likely future research directions. Among recent findings, large-scale epidemiological studies based on Scandinavian population registers, have provided further evidence of substantial heritability and evidence that a wide range of psychotic and non-psychotic disorders partly share genetic risk factors with schizophrenia. In molecular genetics, large collaborative genomewide association studies (GWAS) are providing evidence of common risk variants, each of small effect, and many more variants are likely to be found as samples sizes increase further. A range of rarer chromosomal copy number variants (CNVs) have been associated with schizophrenia, and both GWAS and CNV studies have provided molecular evidence of genetic overlap between schizophrenia and other disorders. There is increasing interest in phenotypes beyond diagnosis, including further clinical variables and endophenotypes. Next-generation sequencing studies are beginning, with the potential for fast, inexpensive sequencing of the whole genome in large samples, and there is an increasing focus on the functional effects of the candidate risk variants that are being identified.

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Cerebral Ventricular Enlargement in Non-Genetic Schizophrenia: a Controlled Twin Study

Cited by 212 publications

References 3 publications

Temporal lobe abnormalities in multigenerational families with schizophrenia

Temporal lobe abnormalities in multigenerational families with schizophrenia

Subtyping schizophrenia: implications for genetic research

Genetics of Schizophrenia and other Psychotic Disorders

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