Cerebriform cutaneous lesions in pemphigus vegetans

Abstract

Pemphigus vegetans is an autoimmune bullous disorder characterized by vegetating lesions commonly over the flexures. A 42-year-old female patient came with pemphigus vegetans presenting with interesting cerebriform morphology of the cutaneous lesions over the flexures. Cerebriform tongue, a morphology with typical pattern of sulci and gyri over dorsum of the tongue is a well-known sign seen in pemphigus vegetans. Interestingly, we noticed the typical sulci and gyri pattern in the skin lesions of pemphigus vegetans over the flexures of the body. This clinical sign can be used as a clue in the diagnosis of pemphigus vegetans. Morphology and physical characteristics are important for the diagnosis of the disease. Clinical signs always give a clue to the probable or possible diagnosis in most of the dermatological conditions.

Is 640 nm high‐fluence visible red light a valuable adjunct for treating pemphigus vegetans? A single case report

“…Veg., which begins as vesicles and bullae, and ruptures into hypertrophic granulating erosions.We diagnosed this case as Hallopeau P. Veg. because the pustules first appeared on the fingers and no pemphigus vulgaris vesicles or bullae were presented 1,2 . Finally, the erosions can evolve into vegetating exuding masses 3‐5 …”

Cerebriform lesions on the trunk

“…In fact, cutaneous plaques resembled a typical pattern of sulci and gyri as seen in cerebriform tongue, a well‐known sign described in P Veg as “Premalatha sign” 3 . Furthermore, in the literature, the cerebriform pattern was also described on the scalp and over flexural lesions 4 . However, cerebriform morphology over the trunk has never been reported in the literature.…”

“…3 Furthermore, in the literature, the cerebriform pattern was also described on the scalp and over flexural lesions. 4 However, cerebriform morphology over the trunk has never been reported in the literature.…”

Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease

“…The typical presentations are deep red irregularly or polycyclic mammillated plaques with macerated epithelial collarette border on intertriginous area, evolving into vegetative plaques [ 1 ]. Cerebriform tongue is a sign of mucosal involvement commonly found in patients [ 2 ]. Two types of Pveg were described: (1) Neumann type which forms vesicles and bullae before turning into dry, hyperkeratotic plaques with fissure and (2) Hallopeau type which forms centrifugal expansion vegetative lesions without vesicles or bullae formation.…”