Cerebritis: An unusual complication of Klebsiella pneumoniae

Majumdar, Mainak; D, Simes; Prabha, Ramesh Damodaran

doi:10.4103/0972-5229.53116

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Plants antimicrobials have been found to be synergistic enhancers in that though they may not have any antimicrobial properties alone, but when they are taken concurrently with standard drugs they enhance the effect of that drug (Kamatou et al, 2006). Chronic inflammation situation caused by infection in living systems (Spooner and Yilmaz, 2011), is the greatest origin of free radicals generated and they can cause extensive damage to tissues and bio-molecules leading to complication of disease conditions, especially degenerative diseases, and extensive lysis (Halliwell et al, 1998).Main examples of these are poststreptococcal glomerulonephritis, acute rheumatic fever, or Bouillaud's disease, that is a delayed inflammatory complication of upper respiratory tract infections by Group A β-hemolytic Streptococcus (McDonald et al, 2004) and Cerebritis caused by Klebsiella pneumoniae in immune competent adults without predisposing factors such as neurosurgery or penetrating brain injury (Majumdar et al, 2009) Many synthetic drugs are used to protect against oxidative damage but they have adverse side effects. Products are not accepted as immunological by living organisms in the same way.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Anti-Inflammatory Activities of Crude Extracts of Three Togolese Medicinal Plants Against Esbl Klebsiella Pneumoniae Strains

Toudji

Thiombiano

Karou³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Pithecellobium dulce (Roxb.) Benth., Securidaca longepedunculata Fresn and Cryptolepis sanguinolenta (Lindl.) Schlt are three plants widely used in the Togolese traditional medicine to treat microbial infections. Some studies reported their antibacterial activity alone but until know there no data concerning their possible interaction with conventional antibiotics. The main objective of this study was to investigate the antibacterial activity of the association of the crude extracts of the three plants with some conventional antibiotics. We further evaluate the antioxidant and the anti-inflammatory activities of the extracts on rat's model. Materials and methods:The antimicrobial activity was evaluated by the broth microdilution assay and the Fractional inhibitory concentrations (FIC) determined by the checkerboard method. The anti-inflammatory activity was evaluated using the Carrageenan-induced rat paw edema model. The antioxidant activities and the phenol contents were determined by spectrophotometry. Results: The MICs of hydroethanolic extract of plants ranged from 3.125 to 100 mg/mL on Klebsiella pneumoniae strains. Synergistic action was observed only with the combination of Imipenem/P. dulce, imipenem/C. sanguinolenta, amikacin/P. dulce and amikacin/C. sanguinolenta against the ESBL negative Klebsiella pneumoniae strain. Of the 21 associations, 15 were antagonistic on the ESBL-producing strains. The indifference effect was observed with the combination of the extract of Securidaca longepedunculata and the following antibiotics imipenem, amikacin, tetracyclin, ciprofloxacin, Cefotaxim; and Sulfametoxazol+Trimethoprim. The in vitro anti-inflammatory with Lipoxygenase inhibition activity was best with C. sanguinolenta extract while the in vivo paw edema model revealed that S. longepedunculata was the highest reducer of paw edema. In addition white blood cells count and biochemical parameters such as total proteins and immunoglobulins were significantly affected by the administration of plant extracts. Conclusion: This study revealed that the three plants although they may inhibit the bacterial growth by themselves, but there is also a possible synergistic action with the commercial antibiotics. Further investigations are needed to identify the active compounds and their mechanism of action.

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Section: Discussionmentioning

confidence: 99%

Antibacterial and Anti-Inflammatory Activities of Crude Extracts of Three Togolese Medicinal Plants Against Esbl Klebsiella Pneumoniae Strains

Toudji

Thiombiano

Karou³

et al. 2017

Afr J Tradit Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…Chronic inflammation situation caused by infection in living systems (Spooner and Yilmaz, 2011), is the greatest origin of free radicals generated and they can cause extensive damage to tissues and bio-molecules leading to complication of disease conditions, especially degenerative diseases, and extensive lysis (Halliwell et al, 1998).Main examples of these are poststreptococcal glomerulonephritis, acute rheumatic fever, or Bouillaud's disease, that is a delayed inflammatory complication of upper respiratory tract infections by Group A β-hemolytic Streptococcus (McDonald et al, 2004) and Cerebritis caused by Klebsiella pneumoniae in immune competent adults without predisposing factors such as neurosurgery or penetrating brain injury (Majumdar et al, 2009) Many synthetic drugs are used to protect against oxidative damage but they have adverse side effects. Products are not accepted as immunological by living organisms in the same way.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Anti-Inflammatory Activities of Crude Extracts of Three Togolese Medicinal Plants Against Esbl Klebsiella Pneumoniae Strains

Toudji¹,

Thiombiano²,

Karou³

et al. 2017

AJTCAM

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Background: Pithecellobium dulce (Roxb.) Benth., Securidaca longepedunculata Fresn and Cryptolepis sanguinolenta (Lindl.) Schlt are three plants widely used in the Togolese traditional medicine to treat microbial infections. Some studies reported their antibacterial activity alone but until know there no data concerning their possible interaction with conventional antibiotics. The main objective of this study was to investigate the antibacterial activity of the association of the crude extracts of the three plants with some conventional antibiotics. We further evaluate the antioxidant and the anti-inflammatory activities of the extracts on rat's model. Materials and methods:The antimicrobial activity was evaluated by the broth microdilution assay and the Fractional inhibitory concentrations (FIC) determined by the checkerboard method. The anti-inflammatory activity was evaluated using the Carrageenan-induced rat paw edema model. The antioxidant activities and the phenol contents were determined by spectrophotometry. Results: The MICs of hydroethanolic extract of plants ranged from 3.125 to 100 mg/mL on Klebsiella pneumoniae strains. Synergistic action was observed only with the combination of Imipenem/P. dulce, imipenem/C. sanguinolenta, amikacin/P. dulce and amikacin/C. sanguinolenta against the ESBL negative Klebsiella pneumoniae strain. Of the 21 associations, 15 were antagonistic on the ESBL-producing strains. The indifference effect was observed with the combination of the extract of Securidaca longepedunculata and the following antibiotics imipenem, amikacin, tetracyclin, ciprofloxacin, Cefotaxim; and Sulfametoxazol+Trimethoprim. The in vitro anti-inflammatory with Lipoxygenase inhibition activity was best with C. sanguinolenta extract while the in vivo paw edema model revealed that S. longepedunculata was the highest reducer of paw edema. In addition white blood cells count and biochemical parameters such as total proteins and immunoglobulins were significantly affected by the administration of plant extracts. Conclusion:This study revealed that the three plants although they may inhibit the bacterial growth by themselves, but there is also a possible synergistic action with the commercial antibiotics. Further investigations are needed to identify the active compounds and their mechanism of action.

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Rates of cerebrospinal fluid infection and the causative organisms following shunt procedures in Saudi Arabia

Al-Sharydah

Melha

Al-Suhibani

et al. 2020

SMJ

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Objectives: To assess the incidence of infection following various cerebrospinal fluid (CSF) shunt procedures among patients with hydrocephalus and related conditions, based on the age of the patient, and to determine the types of pathogens responsible for shunt infections. Methods: This retrospective single center study reviewed the records of patients with culture-confirmed CSF shunt infection diagnosed between January 2012 and December 2017. Cases without central nervous system imaging investigations were excluded. Results: The incidence rate of shunt-related infections was 32.2%. Among the 189 patients whose records were included, Staphylococcus epidermidis (47.5%) and Acinetobacter baumannii (18%) were the most common causative organisms. The incidence of postoperative infection was higher among those who underwent external ventricular drain procedures (65%) than among those who underwent ventriculoperitoneal shunt procedures (24%). There were no intraoperative deaths. However, the postoperative death rate was 12.2% during hospital stay (mean duration = 9 days); 2% of these deaths occurred after shunt removal. Conclusion: The incidence of infections after CSF shunt procedures was high in our tertiary academic hospital during the study period, compared to those reported in similar clinical settings and before developing a detailed standardized protocol for infection control. Although gram-negative organisms were the most prevalent cause of CSF infections, S. epidermidis (a gram-positive organism) was the most commonly encountered causative agent. Shunt protocols should be implemented to address perioperative shortcomings and to reduce overall mortality and morbidity.

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Cerebritis: An unusual complication of Klebsiella pneumoniae

Cited by 3 publications

References 10 publications

Antibacterial and Anti-Inflammatory Activities of Crude Extracts of Three Togolese Medicinal Plants Against Esbl Klebsiella Pneumoniae Strains

Antibacterial and Anti-Inflammatory Activities of Crude Extracts of Three Togolese Medicinal Plants Against Esbl Klebsiella Pneumoniae Strains

Antibacterial and Anti-Inflammatory Activities of Crude Extracts of Three Togolese Medicinal Plants Against Esbl Klebsiella Pneumoniae Strains

Rates of cerebrospinal fluid infection and the causative organisms following shunt procedures in Saudi Arabia

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