Cerebroprotective Activity of a New Hyd Razide Derivative of 2 - Pyrrolidone Under Conditions of Experimental Chronic Cerebrovascular Insufficiency

Abstract

The effect of a new hydrazide derivative of 2-pyrrolidone on neuropsychiatrie deficiency in animals with chronic cerebrovascular insufficiency after course administration was studied. The pathology was modeled by narrowing the lumen of the common carotid arteries to 50 %. The test substances began to be administered from the 40th day and continued for 14 days. The effectiveness of therapy was assessed by the severity of motor, coordination and sensory-motor disorders in animals, which were respectively determined in the tests: Open Field, Rotarod and Adhesive. Stenosis of the common carotid arteries was accompanied by impaired coordination and sensory-motor function. A new derivative of alpha-pyrrolidone improved coordination and sensory function in experimental animals. Cerebroprotective activity of the new derivative of 2-pyrrolidone was comparable to the reference drugs phenotropil and citicoline