Cerebroprotective drugs shorten the hypoxia-induced onset of electrical silence in unanesthetized rats

Zagvazdin, Yuri; Bodó, Michael; Sarkadi, Adam; Szporny, L

doi:10.1006/phrs.2000.0684

Cited by 3 publications

(11 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One iEEG-time it decreased to 2.96 ± 0.38 (mean and outcome variable is the 'iEEG-time', and the other is SD, n = 4). manner described previously [4]. For comparisons among animals, the polarographic currents were normalized to prior to the onset of hypoxia.…”

Section: Measurement Of Isoelectric Eeg (Ieeg)mentioning

confidence: 99%

“…Preliminary data reporting CBF changes summarized in Table III. were provided elsewhere in detail [4]. In Awake rats all data represent venous values, as the sample was taken from the ophthalmic plexus.…”

Section: "•Upper Quartilementioning

confidence: 99%

“…To improve our chances to discover active cerebroprotective therapeutic agents, we developed an awake, freely Screening cerebroprotective drug candidates, promising moving rat model, which was described only briefly in results have been achieved in animal models of stroke; preliminary publications [4][5][6]. but to date, most, if not all Phase III clinical trials have A variety of parameters have been used as outcome failed to predict therapeutic promise [1].…”

Section: Introductionmentioning

confidence: 99%

“…propin-amidine) are presented. Preliminary reports of For each animal, an initial control EEG recording data for pharmacology, CBF, lipid peroxidation and was taken two weeks after electrode implantation, and electroanalytical measurements of this animal model regularly thereafter (at least twice per year) to maintain have been introduced elsewhere [4][5][6]13]. the implanted animal test cohort.…”

Section: Introductionmentioning

confidence: 99%

“…Hypoxia was induced by 100% nitrogen episodes. The oxygen concentration in each chamber inflow with a flow rate of 1.67 1 min-1 [4]. was measured by an oxygen monitor (OM-15, Beckman, CA) in the presence of the animal.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Screening for cerebroprotective agents using an in vivo model of cerebral reversible depolarization in awake rats

Bodó

Perjes

Kalman

et al. 2001

Pharmacological Research

Self Cite

View full text Add to dashboard Cite

Section: Measurement Of Isoelectric Eeg (Ieeg)mentioning

confidence: 99%

Section: "•Upper Quartilementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Screening for cerebroprotective agents using an in vivo model of cerebral reversible depolarization in awake rats

Bodó

Perjes

Kalman

et al. 2001

Pharmacological Research

Self Cite

View full text Add to dashboard Cite

Hypoxia signaling in cancer: Implications for therapeutic interventions

Zhuang

Liu

et al. 2023

MedComm

View full text Add to dashboard Cite

Hypoxia is a persistent physiological feature of many different solid tumors and a key driver of malignancy, and in recent years, it has been recognized as an important target for cancer therapy. Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells. A hypoxic tumor microenvironment (TME) can reduce the effectiveness of other tumor therapies, such as radiotherapy, chemotherapy, and immunotherapy. In this review, we discuss the critical role of hypoxia in tumor development, including tumor metabolism, tumor immunity, and tumor angiogenesis. The treatment methods for hypoxic TME are summarized, including hypoxia‐targeted therapy and improving oxygenation by alleviating tumor hypoxia itself. Hyperoxia therapy can be used to improve tissue oxygen partial pressure and relieve tumor hypoxia. We focus on the underlying mechanisms of hyperoxia and their impact on current cancer therapies and discuss the prospects of hyperoxia therapy in cancer treatment.

show abstract

Eburnamine derivatives and the brain

Vas

Gulyás

2005

Medicinal Research Reviews

100

View full text Add to dashboard Cite

The Apocynaceae plant family contains a great number of so called eburnamine-vincamine alkaloids. Quite a few of these alkaloids exert varied pharmacological activities on the cell multiplication, cardiovascular system, and brain functions. Many derivatives were also synthesized to find pharmacologically active compounds better characterized and safer to be administered than the natural plant alkaloids themselves. We concentrate on the eburnamine structures with cerebral activities in this review. Vincamine, vinburnine, vindeburnol, apovincaminate, and vinpocetine (cis-ethyl-apovincaminate) all share modulatory effects on brain circulation and neuronal homeostasis, bear antihypoxic and neuroprotective potencies to various degrees. The most eminent compound of this class of alkaloids is vinpocetine. Since its introduction to the market as a neuroprotective agent many non clinical and clinical studies proved vinpocetine's effects on calmodulin dependent phosphodiesterase E1, on sodium, calcium channels, peripheral benzodiazepine receptor, and glutamate receptors as well as its clinical usefulness in the treatment of post-ischaemic stroke disease states and various disorders of cerebrovascular origin. Lately, positron emission tomography studies proved that vinpocetine has a rapid uptake in the primate and human brain with a heterogeneous distribution pattern (preference areas: thalamus, basal ganglia, and visual cortex) both after intravenous and oral administration. Vinpocetine exerts beneficial effects in cerebral glucose metabolism and regional cerebral blood flow in chronic post-stroke patients.

show abstract

Cerebroprotective drugs shorten the hypoxia-induced onset of electrical silence in unanesthetized rats

Cited by 3 publications

References 25 publications

Screening for cerebroprotective agents using an in vivo model of cerebral reversible depolarization in awake rats

Screening for cerebroprotective agents using an in vivo model of cerebral reversible depolarization in awake rats

Hypoxia signaling in cancer: Implications for therapeutic interventions

Eburnamine derivatives and the brain

Contact Info

Product

Resources

About