Cerebrospinal fluid beta-2-microglobulin in HIV-1 infection, as a marker of neurological involvement

Perrella, Oreste; Pb, Carrieri; Izzo, E; Marotta, A.; Liberti, A; Soscia, M; Ga, Buscaino

doi:10.1080/01616412.1991.11739980

Cited by 3 publications

(1 citation statement)

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“…Other situations in the HIV infected where β-2M measurement could help are: (a) in predicting vertical transmission from HIV infected mothers [14], (b) in predicting HIV-dementia through CSF levels [15], (c) in predicting neurological involvement through serum/CSF ratio of β-2Μ levels [16], (d) in assessing therapeutic response and patient survival in those who receive anti-retroviral therapy since β-2Μ levels fall with therapy [17,18] and (e) in helping counselling of the HIVinfected.…”

Section: Discussionmentioning

confidence: 99%

Beta-2-Microglobulin Levels in Human-Immunodeficiency Virus Infected Subjects

Rao

Sayal²,

Uppal³

et al. 1997

Medical Journal Armed Forces India

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We studied bc(a-2 microglobulin (β-2Μ) levels in 44 HTV infected subjects belonging to 3 clinical stages as well as in 25 healthy controls. The method used was a competition enzyme immunoassay. In this study, levels of β2-Μ were measured in two groups of HIV infected individuals, the asymptomatic and those with progressive and advanced disease, in order to affirm its role as a surrogate prognostic marker. It was found that mean p-2M levels were 1.28 mg/L in the controls (normal range 0-2.4 mg/L), 11.41 mg/L in the HIV infected subjects, 2.69 mg/L in the asymptomatic HIV infected, 12.14 mg/L in those with persistent generalized lymphadenopathy (PGL) and 39.29 mg/L in the patients with acquired immunodeficiency syndrome. It was concluded that β-2Μ levels were significantly higher in the HIV infected as compared to the controls. Further, the levels were much higher in the IIIV infected with progressive disease/PGL and highest in those who had developed AIDS. β-2Μ is an important surrogate serological marker useful in prognostication of disease process in the HIV infected. Advantages of measuring B-2M levels over p24 antigen detection and CD4 counts were highlighted. MJAFI1997; 53: 251-252

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Section: Discussionmentioning

confidence: 99%

Beta-2-Microglobulin Levels in Human-Immunodeficiency Virus Infected Subjects

Rao

Sayal²,

Uppal³

et al. 1997

Medical Journal Armed Forces India

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Estimation of virological and immunological parameters in subjects from South India infected with human immunodeficiency virus type 1 clade C and correlation of findings with occurrence of neurological disease

et al. 2009

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Several studies carried out in Western countries have demonstrated that a number of virological and immunological markers such as viral loads, cytokines, beta(2)-microglobulin, neopterin, etc., are elevated in the serum and cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)-infected individuals with neurological disease. The neurological manifestations of HIV infection noted in Indian patients is different from those reported in Western countries. Moreover, few studies have investigated the role of virological and immunological parameters with respect to the progression of HIV-1 clade C infection in India. In this study, we measured virological (HIV-1 RNA levels) and immunological parameters (CD4 cell count and inflammatory markers) in the plasma and CSF of HIV-1-infected neurologically asymptomatic and symptomatic (with opportunistic infections and/or dementia) subjects. By using clade-specific polymerase chain reaction (PCR), we ascertained that all samples used for the study were infected with HIV-1 clade C. Among the various laboratory parameters evaluated, high viral loads in the CSF, low CD4 counts, and higher levels of interleukin (IL)-1alpha, IL-6, tumor necrosis factor alpha (TNFalpha), beta(2)-microglobulin, and neopterin were noted in HIV-infected subjects with neurological disease as compared to asymptomatic subjects. These data suggest that the markers evaluated in plasma and CSF samples correlated with occurrence of neurological disease in symptomatic individuals as compared to asymptomatic HIV infected subjects.

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Clinical Utility of Biochemical Analysis of Cerebrospinal Fluid

Watson

Scott

1995

Clinical Chemistry

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In the Review by Watson and Scott entitled "Clinical utility of biochemical analysis of cerebrospinal fluid," 1995; 41:343-60, the total protein concentration in Table 1 should have been expressed in grams per liter (g/L), not milligrams per liter. In the Case Report by S. Coyle, M.D. Penney, P.W. Masters, and B.E. Walker entitled "Early diagnosis of ectopic arginine vasopressin secretion." 1933;39:152-4, in column 2, paragraph 3, page 152, and the title of The 1, the concentration of hypertonic saline infusion should have been expressed as 50 grams per liter (g/L), not milligrams per liter.

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Cerebrospinal fluid beta-2-microglobulin in HIV-1 infection, as a marker of neurological involvement

Cited by 3 publications

References 0 publications

Beta-2-Microglobulin Levels in Human-Immunodeficiency Virus Infected Subjects

Beta-2-Microglobulin Levels in Human-Immunodeficiency Virus Infected Subjects

Estimation of virological and immunological parameters in subjects from South India infected with human immunodeficiency virus type 1 clade C and correlation of findings with occurrence of neurological disease

Clinical Utility of Biochemical Analysis of Cerebrospinal Fluid

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