Cerebrospinal fluid biomarkers of Alzheimer’s disease are associated with carotid plaque score and hemodynamics in intra- and extra-cranial arteries on ultrasonography

Kouzuki, Minoru; Nagano, Masaya; Suzuki, Tetsuya; Katsumata, Yuto; Nakamura, Syouta; Takamura, Ayumi; Urakami, Katsuya

doi:10.1016/j.jocn.2017.12.006

Cited by 7 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After reviewing the full article, 357 articles were excluded, since 232 were reviews, 35 were cross-sectional studies, 22 were reporting incomplete data, 18 were cohort studies, 15 involved subjects whose mean age was under 60, 15 were animal trials, 10 were inaccessible, 8 were twin studies, and 2 had participants using statins. After excluding the above papers, 27 articles ( Table 1) were eligible for inclusion in this meta-analysis (de Bustos et al, 2000;Wada, 2000;Hoshino et al, 2002;Schonknecht et al, 2002;Borroni et al, 2003;Teunissen et al, 2003;Watanabe et al, 2004;Cankurtaran et al, 2005;Yamamoto et al, 2005;Raygani et al, 2006;Ban et al, 2009;Cascalheira et al, 2009;Kolsch et al, 2010; Zengi et al, 2011; Popp et al, 2012Popp et al, , 2013Singh et al, 2012;Xiao et al, 2012;Alam et al, 2014;Chang et al, 2014;Zhao et al, 2014;Li et al, 2015bLi et al, , 2017Yassine et al, 2016;Zheng et al, 2016;Kouzuki et al, 2018;Chen et al, 2019). One Flow diagram of the literature selection is provided in Figure 1.…”

Section: Search Resultsmentioning

confidence: 99%

Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Tang

Wang

Yang

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Objectives: Blood lipid profiles have been ambiguously reported as biomarkers of AD in recent years. This study was conducted to evaluate the correlation between blood lipid levels and AD in later-life and to explore the effectiveness and reliability of blood lipid profiles as biomarkers of AD. Methods: Database searching was conducted using PubMed, the Cochrane Library, EMBASE, and Medline. This study was designed following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) criteria. Review Manager 5.3 (RevMan 5.3) software was adopted to perform meta-analysis evaluating the standard mean difference (SMD) with its 95% confidence intervals (CI). Results: A total of 5,286 participants were enrolled from 27 case-control studies in this meta-analysis. The pooled results demonstrated that total cholesterol (TC) level was significantly associated with AD in late-life (SMD = 0.17, 95% CI: [0.01, 0.32], P = 0.03), especially in the subgroup under 70 years old (SMD: 0.45, 95% CI: [0.11, 0.79], P = 0.01) and the subgroup of Western population (SMD: 0.29, 95% CI: [0.04, 0.53], P = 0.02). In the subgroup under 70 years old, the high-density lipoprotein cholesterol (HDL-C) level (SMD = −0.50, 95% CI: [−0.76, −0.25], P = 0.0001) and the low-density lipoprotein cholesterol (LDL-C) level (SMD = 0.59, 95% CI: [0.02, 1.16], P = 0.04) in the AD group were significantly lower and higher than in the control group, respectively. In the subgroup with a sample size larger than 100 subjects, the LDL-C level was significantly higher in AD patients than in the control elderly group (SMD = 0.31, 95% CI: [0.05, 0.56], P = 0.02). There was no significant association between triglyceride (TG) levels and AD in later-life (SMD = −0.00, 95% CI: [−0.12, 0.12], P = 1.00). Tang et al. Association Between Lipids and AD Conclusion: TC can be a new predictive biomarker of AD or cognitive decline in later-life. Increased TC levels are found to be associated with an elevated risk of AD. Decreased HDL-C levels and increased LDL-C levels may relate to an elevated risk of AD in subjects aged 60-70. Further comprehensive researches will be necessary in the future.

show abstract

Section: Search Resultsmentioning

confidence: 99%

Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Tang

Wang

Yang

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…The meta-regression of confounding factors showed that age (p < 0.01, Adj R-squared = 92.41%; Figure 3A) and CVD (p = 0.01, Adj R-squared = 85.21%; Supplementary Figure 1) exerted an effect on the association of LDL-c with AD; whereas other parameters including BMI (p = 0.063, Adj R-squared = −6.53%; Figure 3B), education (p = 0.50, Adj R-squared = −11.58%; Figure 3C), smoking (p = 0.10, Adj R-squared = 43.90%; Figure 3D), hypertension (p = 0.98, Adj R-squared = −22.11%; Figure 3E) and diabetes mellitus (p = 0.57, Adj R-squared = −13.04%; Figure 3F) had no impact on the outcomes. As shown in Table 2, we found no statistic differences of the pooled weighted characteristics on male gender (OR = 0.86, 95% CI 0.71∼1.04, p = 0.11), education (SMD = 0.26, 95% CI−0.78∼1.30, p < 0.63), smoking (OR = 1.33, 95% CI 0.71∼2.47, p = 0.38), hypertension (OR = 0.91, 95% CI 0.62∼1.35, p = 0.64), diabetes mellitus (OR = 1.02, 95% CI (Caramelli et al, 1999;Paragh et al, 2002;Reitz et al, 2004;Kouzuki et al, 2018;Chen et al, 2019) 340/375 Quartile1 60-70 0.80 (0.23, 1.37) < 0.01 7 (Solfrizzi et al, 2002;Cacabelos et al, 2003;Panza et al, 2003;Wehr et al, 2006;Yavuz et al, 2008;Macesic et al, 2017;Shafagoj et al, 2018) Sample size (n) 11 (Lehtonen and Luutonen, 1986;Caramelli et al, 1999;Lesser et al, 2001;Paragh et al, 2002;Ryglewicz et al, 2002;Solfrizzi et al, 2002;Panza et al, 2003;Wolf et al, 2004;Mamo et al, 2008;Kouzuki et al, 2018;Shafagoj et al, 2018) 0.82∼1.26, p = 0.88) and CVD (OR = 1.28, 95% CI 0.61∼2.70, p = 0.51) between AD and non-dementia controls; whilst there was a positive correlation of age (SMD = 0.62, 95% CI 0.28∼0.95, p < 0.01) and a i...…”

Section: Meta-analysismentioning

confidence: 99%

“…After inspection of the full text, 98 articles were further excluded. Subsequently, 26 eligible articles including a hand search of citations in the reports of published studies or reviews were selected into the meta-analysis (for detailed steps, see Figure 1; Lehtonen and Luutonen, 1986;Kuo et al, 1998;Scacchi et al, 1998; Caramelli et al, 1999;Moroney et al, 1999;Lesser et al, 2001;Hoshino et al, 2002;Paragh et al, 2002;Ryglewicz et al, 2002;Solfrizzi et al, 2002;Cacabelos et al, 2003;Panza et al, 2003;Reitz et al, 2004;Wolf et al, 2004;Watanabe et al, 2005;Yamamoto et al, 2005;Wehr et al, 2006;Mamo et al, 2008;Yavuz et al, 2008;Ban et al, 2009;Warren et al, 2012;Macesic et al, 2017;Kouzuki et al, 2018;Shafagoj et al, 2018;Chen et al, 2019;Tang et al, 2019). Table 1 showed general characteristics of twenty-six studies involving 2,266 AD patients and 4,767 non-dementia controls.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis

Zhou

Liang

Zhang

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Objective: To assess the association between low-density lipoprotein cholesterol (LDL-c) and risk of Alzheimer's disease (AD).Methods: Embase, Pubmed, and Web of Science were searched until June 2019. Standard mean difference (SMD) with 95% confidence intervals (CI) was estimated using random-effects models.Results: Our meta-analysis of 26 studies revealed higher levels of LDL-c in AD than that of non-dementia controls (SMD = 0.35, 95% CI 0.12-0.58, p < 0.01). The meta-regression analysis on confounders showed that age (p < 0.01, Adj R-squared = 92.41%) and cardiovascular disease (p = 0.01, Adj R-squared = 85.21%), but not the body mass index, education, smoking, hypertension and diabetes mellitus, exerted an impact on the relationship between LDL-c and risk of ICH. Further subgroup analysis of age showed LDL-c levels in AD patients aged 60-70 were higher than that of non-dementia (60 ≤ age < 70: SMD = 0.80, 95% CI 0.23-1.37, p < 0.01); but no association between the SMD of AD in LDL-c and age over 70 was noted across the studies (70 ≤ age < 77: SMD = −0.02, 95% CI −0.39∼0.34, p = 9.0; 77 ≤ age < 80: SMD = 0.15, 95% CI −0.17∼0.47, p = 0.35; ≥80: SMD = 0.53, 95% CI −0.04∼1.11, p = 0.07). The concentrations of LDL-c during the quintile interval of 3∼4 were positively associated with AD (121 ≤ concentration < 137: SMD = 0.98, 95% CI 0.13∼1.82, p = 0.02; ≥137: SMD = 0.62, 95% CI 0.18∼1.06, p < 0.01); whereas there was no correlation between AD and LDL-c within the quintile interval of 1∼2 (103.9 ≤ concentration < 112: SMD = 0.08, 95% CI −0.20∼0.35, p = 0.59; 112 ≤ concentration < 121: SMD = −0.26, 95% CI −0.58∼0.06, p = 0.11). Conclusions: Elevated concentration of LDL-c (>121 mg/dl) may be a potential risk factor for AD. This association is strong in patients aged 60-70 years, but vanishes with advancing age.

show abstract

“…A total of 35 studies [14‒16, 19‒21, 27‒55] were included in the review and meta-analysis after full-text review of 86 articles, as shown in Figure 1. Reasons for exclusion of studies that did not fulfill the eligibility criteria are shown in online supplementary material 2.…”

Section: Resultsmentioning

confidence: 99%

Cerebrovascular Hemodynamics in Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Transcranial Doppler Studies

Fresnais,

Ihle-Hansen,

Lundström

et al. 2023

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Introduction: Transcranial Doppler (TCD) sonography is a noninvasive tool for measuring cerebrovascular hemodynamics. Studies have reported alterations in cerebrovascular hemodynamics in normal aging, mild cognitive impairment (MCI), and dementia, as well as in different etiologies of dementia. This systematic review and meta-analysis was designed to investigate the relationship between cerebral blood velocity (CBv) and pulsatility index (PI) in the middle cerebral artery (MCA) in persons with MCI and dementia. Methods: A systematic literature search was conducted in Pubmed, Embase, Cochrane Library, Epistemonikos, PsychINFO, and CINAHL. The search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. After screening of 33,439 articles, 86 were reviewed in full-text, and 35 fulfilled the inclusion criteria. Results: CBv was significantly lower and PI significantly higher in MCA in vascular dementia (VaD) and Alzheimer’s disease (AD) compared to cognitively normal (CN) older persons. Also, CBv was lower in MCI compared to CN. There were no significant differences in CBv in MCA in AD compared with VaD, although PI was higher in VaD compared to AD. Conclusion: Alterations in cerebrovascular hemodynamics are seen in AD, VaD, and MCI. While PI was slightly higher in VaD compared to AD, the reduction in CBv appears to be equally pronounced across neurodegenerative and vascular etiologies of dementia.

show abstract

Cerebrospinal fluid biomarkers of Alzheimer’s disease are associated with carotid plaque score and hemodynamics in intra- and extra-cranial arteries on ultrasonography

Cited by 7 publications

References 22 publications

Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Revealing a Novel Landscape of the Association Between Blood Lipid Levels and Alzheimer's Disease: A Meta-Analysis of a Case-Control Study

Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis

Cerebrovascular Hemodynamics in Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Transcranial Doppler Studies

Contact Info

Product

Resources

About