Cerebrospinal fluid concentrations of free GABA in schizophrenia: No changes after haloperidol treatment

Gattaz, Wagner F.; Roberts, Eugene; Beckmann, H.

doi:10.1007/bf01262959

Cited by 7 publications

(3 citation statements)

References 11 publications

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“… 31 Furthermore, increased CSF GABA levels were observed following 30 days of treatment with sulpiride as well as following treatment with different neuroleptics for many years in long-stay hospitalized patients with schizophrenia. 36 In addition, Gattaz et al 51 observed no change in free CSF GABA levels in patients with schizophrenia after three months of haloperidol treatment. Altogether, it seems implausible that the lower levels of CSF GABA seen in FEP patients are a consequence of antipsychotic treatment.…”

Section: Discussionmentioning

confidence: 99%

CSF GABA is reduced in first-episode psychosis and associates to symptom severity

et al. 2017

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Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains of mental function. γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and is increasingly recognized to have a significant role in the pathophysiology of the disorder. In the present study, cerebrospinal fluid (CSF) concentrations of GABA were analyzed in 41 first-episode psychosis (FEP) patients and 21 age- and sex-matched healthy volunteers by high-performance liquid chromatography. We found lower CSF GABA concentration in FEP patients compared with that in the healthy volunteers, a condition that was unrelated to antipsychotic and/or anxiolytic medication. Moreover, lower CSF GABA levels were associated with total and general score of Positive and Negative Syndrome Scale, illness severity and probably with a poor performance in a test of attention. This study offers clinical in vivo evidence for a potential role of GABA in early-stage schizophrenia.

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Section: Discussionmentioning

confidence: 99%

CSF GABA is reduced in first-episode psychosis and associates to symptom severity

et al. 2017

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“…An increase in CSF GABA levels has been found after 30 d treatment with sulpride and to be correlated with long-term neuroleptic treatment . However, Lichtshtein et al (1978) noted a small but significant decrease in CSF GABA levels after 2 months of neuroleptic treatment while Gattaz et al (1986) observed no change in free CSF GABA levels in schizophrenic patients after 3 months of haloperidol treatment. Lastly, Zander et al (1981) reported that stopping chronic anti-psychotic medication treatment produced no change in CSF GABA levels.…”

Section: Csf Studiesmentioning

confidence: 90%

The GABAergic system in schizophrenia

Blum

Mann

2002

Int. J. Neuropsychopharm.

121

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A defect in neurotransmission involving γ-amino butyric acid (GABA) in schizophrenia was first proposed in the early 1970s. Since that time, a considerable effort has been made to find such a defect in components of the GABAergic system. After a brief introduction focusing on historical perspectives, this paper reviews postmortem and other biological studies examining the following components of the GABAergic system in schizophrenic subjects : the GABA biosynthetic enzyme, glutamate decarboxylase ; free GABA ; the GABA transporter ; the GABA A , GABA B and benzodiazepine receptors ; and the catabolic enzyme GABA transaminase. Additionally, post-mortem studies using morphology or calcium-binding protein to identify GABAergic neurons are also reviewed. Substantial evidence argues for a defect in the GABAergic system of the frontal cortex in schizophrenia which is limited to the parvalbumin-class of GABAergic interneurons.

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“…Trabalhos do nosso grupo de pesquisa demonstraram que inibidores da NOS NG-nitro-Larginina (L-NOARG) e 7-nitroindazol (7NI) previnem os efeitos disruptivos no teste de inibição pré-pulso do reflexo de sobressalto (do inglês, prepulse inhibition; PPI) causados pela administração de anfetamina (SALUM et al, 2011) EBSTEIN et al, 1976;ROBERTS;BECKMANN, 1986). O tratamento com drogas antipsicóticas em pacientes com esquizofrenia aumentou em torno de 50% os níveis de GMPc do líquido cefalorraquidiano.…”

Section: No E Esquizofreniaunclassified

Avaliação da associação de canabidiol e nitroprussiato de sódio no prejuízo sensório-motor induzido pelo tratamento agudo com MK-801

Amaral

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Ao meu melhor amigo Drauzio, não consigo expressar minha gratidão.Ao Pira, por me incentivar a ir atrás dos meus sonhos, mesmo que tenha que abrir mão de muitas coisas.Ao Leoncio, pelas reflexões no biotério, pelos desabafos, por tudo que me ensinou. Temos que aceitar que tudo tem prazo de validade.Ao Belchior, por sempre me ajudar a tomar decisões e me ensinar a argumentar, mesmo inconscientemente.À Dona Neuza, por me ensinar tanto sobre a vida, a humanidade e suas individualidades. À Célia, por toda ajuda com experimentos e por me ensinar que sempre há uma solução para o problema.Ao Charlie, por me acolher em momentos difíceis dessa jornada.À Glauce e ao Maurício, por todo apoio e inspiração.Ao João Francisco, o Jhony Francis, meu amigo e pai científico, por toda a amizade, acolhimento e ensinamentos.Ao Matias, minha terceira mãe, obrigada pela amizade e por cuidar tanto de mim.A todos do laboratório, minha família científica, por todo companheirismo, apoio e aprendizado.Aos funcionários da Faculdade de Odontologia pelo apoio.Aos animais, que tanto amo. Obrigada por todo o conhecimento proporcionado à ciência e à humanidade. Não tenho palavras e nem o direito de agradecer, mas obrigada.A todos os pacientes de esquizofrenia, que me inspiraram por todo o caminho.À minha querida Unifal, pois minha formação não se iniciou e nem terminará aqui.

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Cerebrospinal fluid concentrations of free GABA in schizophrenia: No changes after haloperidol treatment

Cited by 7 publications

References 11 publications

CSF GABA is reduced in first-episode psychosis and associates to symptom severity

CSF GABA is reduced in first-episode psychosis and associates to symptom severity

The GABAergic system in schizophrenia

Avaliação da associação de canabidiol e nitroprussiato de sódio no prejuízo sensório-motor induzido pelo tratamento agudo com MK-801

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