Cerebrospinal Fluid Diacron-Reactive Oxygen Metabolite Levels in Pediatric Patients With Central Nervous System Diseases

Yamanaka, Gaku; Ishii, Chiako; Kawashima, Hisashi; Oana, Shingo; Miyajima, Tasuku; Hoshika, Akinori

doi:10.1016/j.pediatrneurol.2008.04.006

Cited by 19 publications

(15 citation statements)

References 27 publications

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“…These results are in agreement with previous data and demonstrate that obesity is an independent risk factor for plasma lipid peroxidation in children [34,35,36], but they are in contrast to other studies, which, however, evaluated only the alterations of antioxidant status [37]. In our study, we evaluated oxidant/antioxidant status by using two tests which have been reported as clinically significant markers in various diseases [38,39]. In addition, our data clearly demonstrate that d-ROM level was higher in the pre-pubertal obese subjects with MetS than the pubertal ones.…”

Section: Discussionsupporting

confidence: 92%

Oxidative Stress in Obesity and Metabolic Syndrome in Children and Adolescents

et al. 2012

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Background/Aims: The aim of this study was to investigate the alterations in the oxidant/antioxidant status in obese children with and without metabolic syndrome (MetS). Methods: We recruited 25 Caucasian obese children with MetS, 30 Caucasian children with simple obesity and a control group of 30 Caucasian children. We performed diacron-reactive oxygen metabolites (d-ROMs) test and biological antioxidant potential (BAP) test in order to evaluate the oxidant-antioxidant status in recruited patients. Results: d-ROM level was significantly higher in obese children with and without MetS (p = 0.005). The total antioxidant capacity (BAP level) was reduced in MetS and noMetS children compared to controls (p = 0.009). The subjects without MetS had higher d-ROMs test and lower BAP/d-ROMs ratio than subjects with MetS (although not significant). The ratio BAP/d-ROMs was higher in controls than noMetS and MetS children (p < 0.0001). d-ROM level was higher in prepubertal subjects with MetS than pubertal ones (p = 0.03). A direct correlation was found between d-ROM levels and BMI SDS (p = 0.0005), while an inverse correlation was found between BAP and BMI SDS (p = 0.004) and BAP/d-ROMs and BMI SDS (p = 0.0001). Conclusions: This result confirms that fat accumulation plays a key role in the pathogenesis of systemic oxidative stress already during pediatric age.

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Section: Discussionsupporting

confidence: 92%

Oxidative Stress in Obesity and Metabolic Syndrome in Children and Adolescents

et al. 2012

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“…Liu et al reported that the symptomatic WS patients had higher serum IL-2 levels than cryptogenic WS patients [12]. Recently, our assessment of CSF freeradical levels also suggested that symptomatic epilepsy patients demonstrate high tendency of oxidative stress compared with cryptogenic epilepsy patients [3]. Although the number of patients enrolled in our study was not sufficient for statistically significant etiological evaluation of the CSF cytokine level, we established that there was no significant difference in serum cytokine levels, similar to the results of Shiihara et al [16].…”

Section: Discussionsupporting

confidence: 54%

“…Involvement of immunological processes and oxidative stress in the pathogenesis of epilepsy has been suggested on the basis of accumulating evidence from experimental models and human studies [1][2][3]. In particular, members of the interleukin (IL)-1 gene family, namely, IL-1β, and the IL-1 receptor antagonist (IL-1Ra) are suggested to be associated with epileptic pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Increased level of serum interleukin-1 receptor antagonist subsequent to resolution of clinical symptoms in patients with West syndrome

Yamanaka¹,

Kawashima²,

Oana³

et al. 2010

Journal of the Neurological Sciences

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“…Thus, it is tempting to speculate that during epileptic activity there is an increase in ROS content. ROS levels may be associated with the pathogenesis of various pediatric central nervous system diseases, including epilepsy 29. We also demonstrated that the glutathione reduced concentration in the striatum and frontal cortex after seizure activity was decreased, suggesting that its compounds play a role neuroprotective function against neuronal damage produced by increase in the ROS level.…”

Section: Discussionmentioning

confidence: 63%

Acute Seizure Activity Promotes Lipid Peroxidation, Increased Nitrite Levels and Adaptive Pathways Against Oxidative Stress in the Frontal Cortex and Striatum

Júnior

Fonteles

Freitas

2009

Oxidative Medicine and Cellular Longevity

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Previous experiments have shown that the generation of free radicals in rat brain homogenates is increased following pilocarpine-induced seizures and status epilepticus (SE). This study was aimed at investigating the changes in neurochemical mechanisms such as lipid peroxidation levels, nitrite content, glutathione reduced (GSH) concentration, superoxide dismutase and catalase activities in the frontal cortex and the striatum of Wistar adult rats after seizures and SE induced by pilocarpine. The control group was treated with 0.9% saline and another group of rats received pilocarpine (400 mg/kg, i.p.). Both groups were sacrificed 24 h after the treatments. Lipid peroxidation level, nitrite content, GSH concentration and enzymatic activities were measured by using spectrophotometric methods. Our findings showed that pilocarpine administration and its resulting seizures and SE produced a significant increase of lipid peroxidation level in the striatum (47%) and frontal cortex (59%). Nitrite contents increased 49% and 73% in striatum and frontal cortex in pilocarpine group, respectively. In GSH concentrations were decreases of 54% and 58% in the striatum and frontal cortex in pilocarpine group, respectively. The catalase activity increased 39% and 49% in the striatum and frontal cortex, respectively. The superoxide dismutase activity was not altered in the striatum, but it was present at a 24% increase in frontal cortex. These results suggest that there is a direct relationship between the lipid peroxidation and nitrite contents during epileptic activity that can be responsible for the superoxide dismutase and catalase enzymatic activity changes observed during the establishment of seizures and SE induced by pilocarpine.

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Cerebrospinal Fluid Diacron-Reactive Oxygen Metabolite Levels in Pediatric Patients With Central Nervous System Diseases

Cited by 19 publications

References 27 publications

Oxidative Stress in Obesity and Metabolic Syndrome in Children and Adolescents

Oxidative Stress in Obesity and Metabolic Syndrome in Children and Adolescents

Increased level of serum interleukin-1 receptor antagonist subsequent to resolution of clinical symptoms in patients with West syndrome

Acute Seizure Activity Promotes Lipid Peroxidation, Increased Nitrite Levels and Adaptive Pathways Against Oxidative Stress in the Frontal Cortex and Striatum

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