Cerebrospinal fluid dynorphin 1-17 and β-endorphin in late pregnancy and six months after delivery

Lyrenäs, Sven; Nyberg, Fred; Lutsch, Helen; Lindberg, Bo; Terenius, Lars

doi:10.1530/acta.0.1150253

Cited by 21 publications

(4 citation statements)

References 12 publications

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“…Dynorphin is present in the dorsal horn of the normal spinal cord largely in Rexed´s lamina I and II and occasionally in lamina V and VI [158,[310][311][312][313][314][315][316]. Intrathecal administration of dynorphin A (1-17 or 2-17) causes motor dysfunction in rats [see Table 10; 317] and treatment with dynorphin A (1-17) antiserum improves the neurological outcome after SCI (see Table 10; [318]).…”

Section: Dynorphin and Spinal Cord Functionmentioning

confidence: 99%

Pathophysiology of Blood-Spinal Cord Barrier in Traumatic Injury and Repair

Sharma¹

2005

CPD

158

218

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Blood-spinal cord barrier (BSCB) plays an important role in the regulation of the fluid microenvironment of the spinal cord. Trauma to the spinal cord impairs the BSCB permeability to proteins leading to vasogenic edema formation. Several endogenous neurochemical mediators and growth factors contribute to trauma induced BSCB disruption. Studies carried out in our laboratory suggest that those drugs and neurotrophic factors capable to attenuate the BSCB dysfunction following trauma are neuroprotective in nature. Whereas, agents that do not exert any influence on the BSCB disruption failed to reduce cell injury. These observations are in line with the idea that BSCB disruption plays an important role in the pathophysiology of spinal cord injuries. The probable mechanism(s) of trauma induced BSCB dysfunction and its contribution to cell injuries are discussed.

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Section: Dynorphin and Spinal Cord Functionmentioning

confidence: 99%

Pathophysiology of Blood-Spinal Cord Barrier in Traumatic Injury and Repair

Sharma¹

2005

CPD

158

218

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“…In order to further elucidate these mechanisms, cerebro spinal fluid (CSF) was collected for endor phin analyses. The results of these investiga tions will be published elsewhere [9].…”

Section: Introductionmentioning

confidence: 99%

Acupuncture before Delivery: Effect on Labor

Lyrenäs

Lutsch²,

Hetta

et al. 1987

Gynecol Obstet Invest

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Acupuncture treatment in the final weeks of pregnancy has been claimed to shorten the duration of labor in primiparous women. In the present study, the length of the various phases of labor was calculated for 56 primiparous women who were repeatedly treated with manual acupuncture during the month prior to parturition. In vaginally delivering women, the average lengths of the latent and active phase and the second stage of labor were 4.1, 3.4 and 1.4 h, respectively. In a nontreated control group of 112 primiparous women, the corresponding durations were 4.4, 3.5 and 1.1 h. Acupuncture treatment before delivery did not shorten the delivery time. Instead, acupuncture seemed to lengthen pregnancy and to prolong labor, for there was a positive correlation between the number of acupuncture treatments given and the length of gestation, second-stage labor and total delivery time. Based on the results of the present study, it appears possible that the effect of acupuncture is the opposite to that suggested by others, i.e. it lengthens the pregnancy as well as delivery time and does not reduce the duration of labor.

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“…As mentioned above, most active peptides, which have been identified in CNS tissues, are also present in the CSF. These include beta-endorphin, dynorphin A, Leuenkephalin, Met-enkephalin and its C-terminal extensions -Arg and -Arg-Phe (26)(27)(28). Also some atypical opioid peptides, such as beta-casomorphin-8 and hemorphin-7 (29,30) have been detected in CSF.…”

Section: Authentic Opioid Peptides In the Csfmentioning

confidence: 99%

Opioid peptides in cerebrospinal fluid-methods for analysis and their significance in the clinical perspective

Nyberg

2004

Front Biosci

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The discovery of the endogenous opioid peptide systems and their subsequent identification in human cerebrospinal fluid near 30 years ago triggered an intensive research to evaluate the function of these compounds in the clinical perspective. However, for this purpose it was necessary to develop reliable techniques with high sensitivity and reproducibility. Furthermore, it was necessary to assess the chemical nature of the opioid activity present in CSF. Therefore, research on opioid peptides in CSF have to a considerable extent been directed to attempts to characterize the peptide activity present in this fluid in order to identify suitable markers of activity in any particular opioid peptide system. In the clinic these markers have been used in attempts to correlate alterations in peptide levels to various neurological diseases. This article reviews the past and ongoing research on opioid peptide systems in CSF from human with particular emphasis on their relevance in the clinical perspective.

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Cerebrospinal fluid dynorphin 1-17 and β-endorphin in late pregnancy and six months after delivery

Cited by 21 publications

References 12 publications

Pathophysiology of Blood-Spinal Cord Barrier in Traumatic Injury and Repair

Pathophysiology of Blood-Spinal Cord Barrier in Traumatic Injury and Repair

Acupuncture before Delivery: Effect on Labor

Opioid peptides in cerebrospinal fluid-methods for analysis and their significance in the clinical perspective

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