2012
DOI: 10.1182/blood.v120.21.2576.2576
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Cerebrospinal Fluid Flow Cytometry in Acute Lymphoblastic Leukemia/Lymphoma: Is It Beneficial?.

Abstract: 2576 Cerebrospinal fluid (CSF) involvement by leukemic blasts occurs in fewer than 10 % of adult patients with newly diagnosed acute lymphoblastic leukemia/lymphoma (ALL). Leukemic meningitis is diagnosed by microscopic detection of blasts in the CSF. Flow cytometry is a highly sensitive tool for detection of aberrant cells. We sought to analyze the additional benefit flow cytometry might provide for the diagnosis of leukemic meningitis. Between 11/2007 and 8/2011, 80 patients were diagnosed wit… Show more

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“…Few studies have also aimed to describe its role in the detection of leukemic blasts in cerebrospinal fluid. Many studies have proposed its usefulness given the low sensitivity of cytology which is unable to detect infiltration with low cell counts since it relies solely on the observer's experience and training in distinguishing pathological cells from normal lymphocytes [6,[16][17][18][19][20].…”
Section: Discussionmentioning
confidence: 99%
“…Few studies have also aimed to describe its role in the detection of leukemic blasts in cerebrospinal fluid. Many studies have proposed its usefulness given the low sensitivity of cytology which is unable to detect infiltration with low cell counts since it relies solely on the observer's experience and training in distinguishing pathological cells from normal lymphocytes [6,[16][17][18][19][20].…”
Section: Discussionmentioning
confidence: 99%