Cerebrospinal fluid glutamic oxalacetic transaminase and lactic dehydrogenase activities in children with neurologic disorders

Lending, Miriam; Slobody, Lawrence B.; Mestern, Joan

doi:10.1016/s0022-3476(64)80406-6

Cited by 28 publications

(14 citation statements)

References 15 publications

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“…Non-specific febrile convulsions do not result in an elevation in CSF LD values above the 'normal' group; it may, however, be of clinical interest to note that in all five cases of epileptic convulsions LD values were greater than the presently determined upper limit of normal. These results are compatible with those obtained elsewhere (Williams and Hawkins, 1968;Jakoby and Jakoby, 1958;Lending et al, 1964;Beaty and Oppenheimer, 1968). The CSF LD isoenzyme patterns characteristic of each neurological disorder investigated in this study also compare with the results of previous reports (Beaty and Oppenheimer, 1968;van der Halm, Zondag and Klein, 1963).…”

Section: Other Patient Groupssupporting

confidence: 94%

Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders.

Pv¹,

Carey²,

Pollard³

1975

J Clin Pathol

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Two hundred and thirty-four cerebrospinal fluid (CSF) specimens from 183 different children were analysed for total lactate dehydrogenase (LD) activity and LD isoenzyme distribution. The LD activities were elevated in the CSF of patients with meningitis, especially with bacterial infections, and with central nervous system (CNS) leukaemia. The CSF LD isoenzyme patterns of both groups generally reflected the number and distribution of lymphocytes and granulocytes in the CSF. Increases in CSF LD levels also occurred in patients with other neurological disorders, such as hydrocephalus, raised intracranial pressure, and epileptic seizures. However, no significant increases in CSF LD activity nor abnormality of the isoenzyme distribution were noted in children who had had a non-specific febrile convulsion.

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Section: Other Patient Groupssupporting

confidence: 94%

Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders.

Pv¹,

Carey²,

Pollard³

1975

J Clin Pathol

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“…The underlying mechanism causing these CSF LDH changes in patients with pathology of the central nervous system is not understood. Some researchers have suggested a disturbance in the blood-brain barrier which enables plasma LDH to reach the CSF, or production of LDH by neoplastic tissue or by white blood cells and exogenous bacterial sources (1,3,9). However, neither of these theories has yet been proven.…”

Section: Discussionmentioning

confidence: 99%

“…Lactic dehydrogenase (LDH) is a fermentative enzyme present in many tissues and body fluids, including the cerebrospinal fluid (CSF). In earlier studies higher levels of LDH in the CSF of patients with intracranial malignancies and bacterial meningitis compared with those of healthy individuals have been reported (1,2). In 1964, Lending et al (1) recommended that a CSF LDH activity of 40 U/L be considered the upper limit of normal.…”

mentioning

confidence: 92%

“…In earlier studies higher levels of LDH in the CSF of patients with intracranial malignancies and bacterial meningitis compared with those of healthy individuals have been reported (1,2). In 1964, Lending et al (1) recommended that a CSF LDH activity of 40 U/L be considered the upper limit of normal. Later studies showed that healthy individuals are characterized by a specific LDH isoenzyme pattern, namely a preponderance of LDH-1, followed by LDH-2, LDH-3 and LDH-4 (2,3).…”

mentioning

confidence: 92%

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Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with febrile convulsions

et al. 2003

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dehydrogenase isoenzyme in cerebrospinal fluid of children with febrile convulsions. Acta Paediatr 2003; 92: 186-189. Stockholm. ISSN 0803-5253Aim: To study the lactic dehydrogenase isoenzyme values in children with simple and complex febrile convulsions. Methods: Cerebrospinal fluid samples were collected from 115 children, 57 with simple febrile convulsions, 27 with complex febrile convulsions and 31 with no neurological or intracranial pathology (controls). Lactic dehydrogenase activity and isoenzyme levels were measured on a Hitachi analyser. Results: Mean total lactic dehydrogenase activity was similar in the three groups. In the control group, lactic dehydrogenase-1 was the main fraction, followed by lactic dehydrogenase-2 and lactic dehydrogenase-3; only small percentages of lactic dehydrogenase-4 and lactic dehydrogenase-5 were detected. In the febrile convulsion group, the lactic dehydrogenase-1 fraction percentage was lower and lactic dehydrogenase-2, lactic dehydrogenase-3 percentages were higher than those in the control group; and the differences were statistically significant between the control and study groups (p < 0.01). Values of lactic dehydrogenase-4 and lactic dehydrogenase-5 were similar in all three groups.Conclusion: This is the first report on the lactic dehydrogenase isoenzyme pattern in the cerebrospinal fluid of patients with simple and complex febrile convulsions. The important finding that focal and general febrile convulsions are not associated with cell damage and changes in aerobic and anaerobic metabolism as lactic dehydrogenase remained unchanged. Analysis of cerebrospinal fluid lactic dehydrogenase isoenzyme levels can assist clinicians in differentiating febrile convulsions from clinical situations that might mimic them.

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“…LEND~G U. Mitarb. [29] haben ebenfalls beim Hydrocephalus hohe GOT-Werte im Liquor gefunden, die sich naeh ableitender Operation nicht mehr welter erhShten oder sogar absanken; ~hnliehe Befunde konnten ffir die IDH, MDH, fl-Glucuronidase [36] und CPK erhoben werden.…”

Section: Ergebnisseunclassified

Untersuchungen �ber Enzymaktivit�ten im Liquor cerebrospinalis bei Kindern mit Encephalitis, ser�ser Meningitis und Hydrocephalus

Sitzmann¹

1969

Z. Kinder-Heilk.

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Cerebrospinal fluid glutamic oxalacetic transaminase and lactic dehydrogenase activities in children with neurologic disorders

Cited by 28 publications

References 15 publications

Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders.

Diagnostic significance and source of lactate dehydrogenase and its isoenzymes in cerebrospinal fluid of children with a variety of neurological disorders.

Lactic dehydrogenase isoenzyme in cerebrospinal fluid of children with febrile convulsions

Untersuchungen �ber Enzymaktivit�ten im Liquor cerebrospinalis bei Kindern mit Encephalitis, ser�ser Meningitis und Hydrocephalus

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