Cerebrospinal fluid levels of tumor necrosis factor alpha and aquaporin 1 in patients with mild cognitive impairment and idiopathic normal pressure hydrocephalus

Castañeyra-Ruiz, Leandro; González-Marrero, Ibrahim; Carmona-Calero, Emilia M.; Abreu-González, Pedro; Lecuona, Marı́a; Brage, Liberto; Rodríguez, Estéban M.; Castañeyra-Perdomo, Agustín

doi:10.1016/j.clineuro.2016.04.025

Cited by 26 publications

(21 citation statements)

References 23 publications

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“…Initially it appeared only in the apical cell membranes, at midgestation also in the basolateral membranes and, after 25 GW, expression was exclusively in the apical membrane, as also described by Johansson et al ( 2005 ) and Gömöri et al ( 2006 ). In the adulthood, we also found a supranuclear expression of the AQP1, recently described for our group (Castañeyra-Ruiz et al, 2016 ). Therefore the polarization of AQP1 expression undergoes dynamic changes along gestation, possibly related with CSF production that might provide different ventricular pressure forces to support brain expansion at distinct moments of corticogenesis.…”

Section: Discussionsupporting

confidence: 87%

A Distal to Proximal Gradient of Human Choroid Plexus Development, with Antagonistic Expression of Glut1 and AQP1 in Mature Cells vs. Calbindin and PCNA in Proliferative Cells

et al. 2016

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The choroid plexuses (ChP) are highly vascularized tissues suspended from each of the cerebral ventricles. Their main function is to secret cerebrospinal fluid (CSF) that fills the ventricles and the subarachnoid spaces, forming a crucial system for the development and maintenance of the CNS. However, despite the essential role of the ChP–CSF system to regulate the CNS in a global manner, it still remains one of the most understudied areas in neurobiology. Here we define by immunohistochemistry the expression of different proteins involved in the maturation and functionality of the ChP from the late embryological period to maturity. We found an opposite gradient of expression between aquaporin 1 (AQP1) and glucose transporter 1 (Glut 1) that define functional maturation in the ChP periphery, and proliferating cell nuclear antigen (PCNA) and calbindin (CB), present in the ChP root zone with proliferative activity. We conclude that the maturation of the ChP matures from distal to proximal, starting in the areas nearest to the cortex, expressing in the distal, mature areas AQP1 and Glut1 (related to ChP functionality to support cortex development), and in the proximal immature areas (ChP root) CB and PCNA related to progenitor activity and proliferation.

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Section: Discussionsupporting

confidence: 87%

A Distal to Proximal Gradient of Human Choroid Plexus Development, with Antagonistic Expression of Glut1 and AQP1 in Mature Cells vs. Calbindin and PCNA in Proliferative Cells

et al. 2016

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“…S1P-based signaling through S1P receptor 1 (S1PR1) rapidly and reversely reduces basal P-glycoprotein transport activity at the blood-brain and blood-spinal cord barriers and the S1P efflux from brain and spinal cord endothelial cells is mediated by the multidrug resistance-associated protein 1 (Mrp1, Abcc1) 43 . Furthermore, the activation of the proinflammatory pathway (TNF-α), typical of AD, decreases the P-glycoprotein activity and it has been described that iNPH patients show higher levels of CSF TNF-α compared to MCI subjects 44 leading to speculate on the role of SP1 as a possible marker for differential diagnosis but also in this case results are contradictory since other publications describe low 45 or unchanged 46 levels of TNF-α, suggesting that also in this case the inter individual variability plays a major role.…”

Section: Discussionmentioning

confidence: 99%

Particular CSF sphingolipid patterns identify iNPH and AD patients

Torretta

Arosio

Barbacini

et al. 2018

Sci Rep

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Idiopathic normal pressure hydrocephalus (iNPH) is characterized by reversible neurological symptoms due to an impairment in cerebrospinal fluid (CSF) clearance. In these patients, cognitive functions are severely impaired, with a scenario similar to Alzheimer’s disease (AD), making the differential diagnosis difficult and highlighting the need of new markers. We analyzed the composition of sphingolipids (SLs) in serum, by combining a single phase extraction with a high-performance thin-layer chromatography (HPTLC) primuline-profiling, and, in CSF, by MALDI profiling and LC-MS. Ceramides and sphingomyelins (SMs) were similar in serum of iNPH and AD patients compared to healthy controls, whereas, in CSF, MALDI profiling indicated that: 1) SM C24:1 is significantly decreased in AD compared to iNPH patients and controls (Kruskal-Wallis p-value < 0.00001); 2) phosphatidylcholine (PC) 36:2 is increased in iNPH patients (p-value < 0.001). LC-MS identified an increasing trend of Cer C24:0 and of a set of SMs in patients with AD, a significant decrease of sphingosine-1-phosphate (S1P) (t-test p-value 0.0325) and an increase of glucosylceramide (GlcCer) C24:0 (p-value 0.0037) in AD compared to iNPH patients. In conclusion CSF PC 36:2, SM C24:1, S1P, and GlcCer can contribute to improve the differential diagnosis of patients with iNPH or AD and foster preventive therapeutic strategies in the early phase of the disease.

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“…Neuroinflammatory responses, which are characterized by the release of inflammatory mediators, such as cytokines and chemokines, 62,63 are prominent during iNPH. Altered levels of inflammatory cytokines in the CSF, as summarized in Table 1, have been reported 64‐70 . Among them, TNF‐α is the most extensively studied 64,67,70 .…”

Section: Hypoperfusion Leads To Neurophysiological Changes In Inphmentioning

confidence: 99%

Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus

Wang

Zhang

et al. 2020

CNS Neurosci Ther

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First defined in 1965, idiopathic normal pressure hydrocephalus (iNPH)is a surgically reversible neurological disorder in adults. It is characterized by dementia, gait disturbance, and urinary incontinence (known as Hakim's triad). 1,2 INPH is not a rare clinical entity. The prevalence of iNPH has been estimated to be 10 per 100 000 to 22 per 100 000 overall, with 1.30% in those aged ≥65 years and 5.9% in those aged ≥80 years. 3,4 One of the core features of iNPH is that the cerebrospinal fluid (CSF) pressure of an iNPH patient is within normal ranges. 2 Typical brain imaging of iNPH displays ventriculomegaly, periventricular hyperintensities, wide Sylvian fissures, narrowed subarachnoid space, and cortical sulci at the high convexity. 5 In contrast to the secondary normal pressure hydrocephalus with known etiology, the exact cause of iNPH is unknown. 6 Its specific pathogenesis also remains elusive, although several

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Cerebrospinal fluid levels of tumor necrosis factor alpha and aquaporin 1 in patients with mild cognitive impairment and idiopathic normal pressure hydrocephalus

Cited by 26 publications

References 23 publications

A Distal to Proximal Gradient of Human Choroid Plexus Development, with Antagonistic Expression of Glut1 and AQP1 in Mature Cells vs. Calbindin and PCNA in Proliferative Cells

A Distal to Proximal Gradient of Human Choroid Plexus Development, with Antagonistic Expression of Glut1 and AQP1 in Mature Cells vs. Calbindin and PCNA in Proliferative Cells

Particular CSF sphingolipid patterns identify iNPH and AD patients

Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus

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