Cerebrospinal Fluid Protein Profiles in Alzheimer’s Dementia Patients: A Bioinformatic Approach

Misra, Anamika; Chakrabarti, Sankha Shubhra; Gambhir, Indrajeet Singh; Baghel, Meghraj Singh; Patil, Yugendra R.

doi:10.4103/aian.aian_206_23

Cited by 1 publication

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“…An early meta-analysis of clinical and autopsy-based studies, for example, found that the association between APOE ε4 and AD was weaker among African Americans and Hispanics compared to Caucasians, but stronger in Japanese [6]. In India, the few studies that have investigated the relationship between APOE ε4 and AD suggest that its effect size is similar to that observed in populations of European ancestry [35][36][37][38]. However, prior studies in India have primarily relied on geographically restricted samples.…”

Section: Introductionmentioning

confidence: 99%

Effect ofAPOEε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI-DAD

Wang,

Zhao,

Moorjani

et al. 2024

Preprint

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BACKGROUNDWe investigated effects ofAPOEε4 and its interactions with sociodemographic characteristics on cognitive measures in 2,563 South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD).METHODSLinear regression models were used to assess the association betweenAPOEε4 and global- and domain-specific cognitive function. Effect modification by age, sex, and education were explored using cross-product interaction terms and subgroup analyses.RESULTSAPOEε4 was inversely associated with most cognitive measures. This association was stronger in the older age group (age >68) for general cognitive function, orientation, and language/fluency, as well as in females for memory and language/fluency. Interaction betweenAPOEε4 and education was mostly nonsignificant.DISCUSSIONAPOEε4 is associated with lower cognitive function in South Asians from India, with a more pronounced impact observed in females and older individuals.

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