Cerebrospinal fluid proteomic profile of frailty: Results from the PROLIPHYC cohort
Sophie Guillotin,
Amit Fulzele,
Alexandra Vallet
et al.
Abstract:Frailty is a clinical state reflecting a decrease in physiological reserve capacities, known to affect numerous biological pathways and is associated with health issues, including neurodegenerative diseases. However, how global protein expression is affected in the central nervous system in frail subject remains underexplored. In this post hoc cross‐sectional biomarker analysis, we included 90 adults (52–85 years) suspected of normal pressure hydrocephalus (NPH) and presenting with markers of neurodegenerative… Show more
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