Cerebrospinal fluid pulse wave velocity measurements: In vitro and in vivo evaluation of a novel multiband cine phase‐contrast MRI sequence

Sonnabend, Kristina; Brinker, Gerrit; Maintz, David; Bunck, Alexander C.; Weiss, Kilian

doi:10.1002/mrm.28430

Cited by 7 publications

(14 citation statements)

References 35 publications

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“…The current study provides normative data for spinal CSF ow in experimentally naïve anaesthetised domestic pigs as a baseline and comparison for future SCI studies. The study provides evidence that spinal CSF ow in anaesthetised and ventilated pigs is lower, and has slower velocity wave propagation, than in conscious humans, but is similar to that in anaesthetised NHP (15,19,34,36).…”

Section: Discussionmentioning

confidence: 75%

“…Velocity wave propagation speed can be used to approximate pulse wave velocity (pressure wave propagation) since it has been shown that they are nearly identical under certain conditions (36). Because of this, some studies use the term 'pulse wave velocity' rather than VWS, for the identical measure (19,34). It has been hypothesised that CSF pressure waves originate in the intracerebral arteries and propagate in a caudal direction (51); however, the origin of the pulse remains unresolved since there are other studies which suggest local sources (15,52,53).…”

Section: Discussionmentioning

confidence: 99%

“…In cardiovascular diagnostics, pulse wave velocity is a measure of vessel compliance. VWS has recently been reported for spinal CSF ow studies (34,36,54) where it likely re ects compliance of the spinal cord tissue, dura, and surrounding tissues (55). A one-dimensional tube model of the spinal SAS has been used to show that increasing spinal compliance results in slower VWS and greater attenuation of the pulse (56).…”

Section: Discussionmentioning

confidence: 99%

“…Velocity Wave Propagation Speed CSF velocity wave speed (VWS) (34) was estimated for each animal as the distance between the C2/C3 and L1/L2 spinal levels divided by the time taken for the velocity wave (peak systolic, peak diastolic) to travel that distance. The distance from C2/C3 to the L1/L2 intervertebral disc was measured across both T2 FSE scans (summed distance from C2/C3 to T11/T12, and T11/T12 to L1/L2) with a spline placed along the centre of the spinal cord on a sagittal view, using Materialise Mimics software (Version 22.0, Materialise, NV).…”

Section: Phase Contrast Magnetic Resonance Imaging Acquisitionmentioning

confidence: 99%

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Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging

Bessen

Gayen

Quarrington

et al. 2022

Preprint

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Background Detecting changes in pulsatile cerebrospinal fluid (CSF) flow may assist clinical management decisions, but spinal CSF flow is relatively understudied. Traumatic spinal cord injuries (SCI) often cause spinal cord swelling and subarachnoid space (SAS) obstruction, potentially causing pulsatile CSF flow changes. Pigs are emerging as a favoured large animal SCI model; therefore, the aim of this study was to characterise CSF flow along the healthy pig spine. Methods Phase-contrast magnetic resonance images (PC-MRI), retrospectively cardiac gated, were acquired for fourteen laterally recumbent, anaesthetised and ventilated, female domestic pigs (22–29 kg). Axial images were obtained at C2/C3, T8/T9, T11/T12 and L1/L2. Dorsal and ventral SAS regions of interest (ROI) were manually segmented. CSF flow and velocity were determined throughout a cardiac cycle. Linear mixed-effects models, with post hoc comparisons, were used to identify differences in peak systolic/diastolic flow, and maximum velocity (cranial/caudal), across spinal levels and dorsal/ventral SAS. Velocity wave speed from C2/L3 to L1/L2 was calculated. Results PC-MRI data were obtained for 11/14 animals. Pulsatile CSF flow was observed at all spinal levels. Peak systolic flow was greater at C2/C3 (dorsal: -0.37 ± 0.17 mL/s, ventral: -0.19 ± 0.17 mL/s) than T8/T9 (dorsal: -0.04 ± 0.03 mL/s, ventral: -0.09 ± 0.09 mL/s) in both SAS regions (p < 0.001), and not different between thoracolumbar levels (p > 0.05). Peak diastolic flow was greater at C2/C3 (0.179 ± 0.06 mL/s) compared to T8/T9 (0.04 ± 0.02 mL/s) dorsally (p < 0.001), but not different ventrally (p = 1.000). Caudal maximum velocity at C2/C3 was greater than at thoracolumbar levels dorsally and ventrally (p < 0.001), but not different ventrally for cranial maximum velocity (p > 0.05). Diastolic velocity wave speed was 1.41 ± 0.39 m/s dorsally and 1.22 ± 0.21 m/s ventrally, and systolic velocity wave speed was 1.02 ± 0.25 m/s dorsally and 0.91 ± 0.22 m/s ventrally. Conclusions In anaesthetised and ventilated domestic pigs, spinal CSF has lower pulsatile flow and slower velocity wave propagation, compared to humans. This study provides baseline CSF flow at spinal levels relevant for future SCI research in this animal model.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Phase Contrast Magnetic Resonance Imaging Acquisitionmentioning

confidence: 99%

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Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging

Bessen

Gayen

Quarrington

et al. 2022

Preprint

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“…e pulse signal is, in fact, not certain, so the pulse signal is not stable and changes periodically. It changes with the changes of various physiological and psychological factors of the human body and the external environment, and the waveform obtained through instruments and equipment will also change accordingly [14]. Pulse signals have the following characteristics:…”

Section: System Software Designmentioning

confidence: 99%

Psychological Stress Detection and Early Warning System Based on Wireless Network Transmission

2021

Scientific Programming

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To improve the accuracy of stress detection and stress warning errors, this paper designed a new psychological stress detection and warning system based on wireless network transmission. To achieve this objective, we established a real-time setup. The hardware of the system is composed of pulse acquisition module, signal low-pass filtering and amplification module, real-time clock module, wireless network transmission module, and power supply module, respectively. Based on the aforementioned hardware platform, the system software is designed, mainly through the construction of pulse signal noise and the use of wavelet denoising threshold for sensing wavelet packet inverse transformation, to get the reconstructed signal. The peak point of the reconstructed signal is determined, and the value of pulse signal is extracted. According to the characteristic value’s extraction results, the degree of psychological stress is quantified using the psychological stress index (PSI). When the PSI exceeds a predefined threshold, it indicates an early warning of psychological stress. The experimental results show that the psychological stress detection of our system is consistent with the expert evaluation results, the warning time is short, and the practical application effect is good.

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A novel strategy to increase the therapeutic potency of GBM chemotherapy via altering parenchymal/cerebral spinal fluid clearance rate

Umlauf,

Frampton,

Cooper

et al. 2023

Journal of Controlled Release

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Cerebrospinal fluid pulse wave velocity measurements: In vitro and in vivo evaluation of a novel multiband cine phase‐contrast MRI sequence

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 35 publications

Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging

Characterising spinal cerebrospinal fluid flow in the pig with phase-contrast magnetic resonance imaging

Psychological Stress Detection and Early Warning System Based on Wireless Network Transmission

A novel strategy to increase the therapeutic potency of GBM chemotherapy via altering parenchymal/cerebral spinal fluid clearance rate

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