Cerebrospinal fluid purine metabolites after complex febrile convulsions

Abstract

Adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine and uric acid were determined in cerebrospinal fluid (CSF) of 15 children after complex febrile seizures (CFS) and in 27 after simple febrile seizures (SFS), and compared with those in a control group of 63 children. There was no statistically significant difference between the groups for any of these metabolites, suggesting that CFS and SFS neither significantly disturb the metabolism of nucleotides, nucleosides or bases nor significantly deplete neuron adenosine triphosphate levels.

Biochemical parameters predictive of neuronal damage in children with neonatal hypoxic ischemia

“…These findings suggest reversible or temporary neuronal energy depletion. However, in the simple febrile convulsions group, we did not detect any significant difference with respect to the control group in the concentration of purine metabolites, confirming the benign character of convulsions of this type [2,3,[135][136][137]141,143]. The concentration of NSE was normal in both types of febrile convulsion, indicating that it does not induce neuronal necrosis or lesion [3,143].…”

“…We have determined CSF levels of purine nucleotide degradation products and in some cases NSE in various pediatric clinical conditions [2,3,[131][132][133][134][135][136][137][138][139][140][141][142][143][144][145][146]. In children with severe HIE, we have observed very high levels of AMP, IMP, inosine, guanosine, adenine, hypoxanthine, xanthine and uric acid.…”